Hydrocortisone sodium phosphate
- CAS No.
- 6000-74-4
- Chemical Name:
- Hydrocortisone sodium phosphate
- Synonyms
- Coriphate;Efcortesol;Physiocortison;Hydrocortone phosphate;CORTISOL SODIUM PHOSPHATE;Sodium cortisol 21-phosphate;Hydrocortisone 21-disodium salt;Hydrocortisone phosphate sodium;Hydrocortisone disodium phosphate;SODIUM HYDROCORTISONE-21-PHOSPHATE
- CBNumber:
- CB2397209
- Molecular Formula:
- C21H29O8P.2Na
- Molecular Weight:
- 486.41
- MDL Number:
- MFCD00152562
- MOL File:
- 6000-74-4.mol
| alpha | D25 +120° (H2O) |
|---|---|
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| CAS DataBase Reference | 6000-74-4(CAS DataBase Reference) |
| FDA UNII | 0388G963HY |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H373-H312-H332-H361 |
| Precautionary statements | P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P260-P314-P501-P201-P202-P281-P308+P313-P405-P501 |
Hydrocortisone sodium phosphate price More Price(2)
Hydrocortisone sodium phosphate Chemical Properties,Uses,Production
Originator
Corphos,Tilden Yates,US,1959
Uses
Hydrocortisone Sodium Phosphate is the sodium phosphate salt of the corticosteroid Hydrocortisone (H714615).
Definition
ChEBI: An organic sodium salt that is the disodium salt of cortisol phosphate.
Manufacturing Process
21-iodo-11β:17α-dihydroxypregn-4-ene-3,20-dione (5.0 g) in pure acetonitrile
(125 ml) was mixed with a solution of 90% phosphoric acid (2.5 ml) and
triethylamine (7.5 ml) in acetonitrile (125 ml) and boiled under reflux for 4
hours. The solvent was removed in vacuo and the residue, dissolved in
ethanol (20 ml) and water (80 ml), was passed down a column of Zeo-Karb
225 (H+form) (60 g) made up in 20% alcohol. Elution was continued with
20% alcohol (50 ml), 50% alcohol (50 ml) and alcohol (150 ml). The eluate
was at first cloudy, but by the end of the elution it was clear and nonacid.
The eluate was titrated to pH 7 with 0.972N NaOH (63 ml). Removal of
solvent left a gum, which was boiled with methanol (400 ml) for 20 minutes.
The solid insoluble inorganic phosphate was filtered off and washed with
methanol (200 ml). The slightly cloudy filtrate was filtered again, and
evaporated to dryness in vacuo. The residual gum dissolved readily in water
(40 ml) and on addition of acetone (600 ml) to the solution a mixture of
sodium salts of hydrocortisone 21-phosphate separated as a white solid. This
was collected after 2 days, washed with acetone and dried at 100°C/0.l mm/2
hr to constant weight. Yield 4.45 g.
brand name
Hydrocortone (Merck).
Therapeutic Function
Glucocorticoid
Hydrocortisone sodium phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9271 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29067 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
View Lastest Price from Hydrocortisone sodium phosphate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-03-06 | Hydrocortisone Sodium Phosphate
6000-74-4
|
US $8.00 / Kg/Bag | 10g | 99% | 10000kg | Hebei Guanlang Biotechnology Co,.LTD | |
 |
2021-07-02 | Hydrocortisone sodium phosphate
6000-74-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-06-05 | Hydrocortisone sodium phosphate USP/EP/BP
6000-74-4
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- Hydrocortisone Sodium Phosphate
6000-74-4
- US $8.00 / Kg/Bag
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
-
- Hydrocortisone sodium phosphate
6000-74-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Hydrocortisone sodium phosphate USP/EP/BP
6000-74-4
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
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