11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
- CAS No.
- 13951-70-7
- Chemical Name:
- 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
- Synonyms
- 16α-hydroxy-prednisolone;11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione;11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;16-ALPHA-HYDROXY PREDNISOLONE;11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione;16b;20-dione;4-diene-3;BNKY015-BD04
- CBNumber:
- CB7352308
- Molecular Formula:
- C21H28O6
- Molecular Weight:
- 376.44
- MDL Number:
- MFCD00872019
- MOL File:
- 13951-70-7.mol
- MSDS File:
- SDS
Melting point | 235-238°C |
---|---|
Boiling point | 591.5±50.0 °C(Predicted) |
Density | 1.38±0.1 g/cm3(Predicted) |
vapor pressure | 0Pa at 25℃ |
storage temp. | Sealed in dry,2-8°C |
solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
form | Solid |
pka | 11.93±0.70(Predicted) |
color | White to Light Yellow |
Water Solubility | 815mg/L at 20℃ |
LogP | 0.8 at 25℃ |
CAS DataBase Reference | 13951-70-7(CAS DataBase Reference) |
FDA UNII | SW97540DC2 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08 |
---|---|
Signal word | Warning |
Hazard statements | H361 |
Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione price More Price(31)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 27169 | 16α-hydroxy Prednisolone | 13951-70-7 | 1g | $32 | 2024-03-01 | Buy |
Cayman Chemical | 27169 | 16α-hydroxy Prednisolone | 13951-70-7 | 25g | $479 | 2024-03-01 | Buy |
Cayman Chemical | 27169 | 16α-hydroxy Prednisolone | 13951-70-7 | 5g | $139 | 2024-03-01 | Buy |
Cayman Chemical | 27169 | 16α-hydroxy Prednisolone | 13951-70-7 | 10g | $243 | 2024-03-01 | Buy |
TRC | T296075 | 11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione | 13951-70-7 | 500mg | $245 | 2021-12-16 | Buy |
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Chemical Properties,Uses,Production
Related substances
Prednisolone is a synthetic adrenocortical steroid drug with predominantly glucocorticoid properties.
Chemical Properties
White Crystalline Solid
Uses
11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione (Budesonide EP Impurity A) is a metabolite of Budesonide (B689490), an anti-inflammatory agent.
Uses
A metabolite of Budesonide (B689490), an antiinflammatory agent.
Synthesis
501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BIONNA MEDICINE CO.,LTD | 01056380788-8515; +8618518759099 | 790226113@qq.com | China | 52 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10991 | 58 |
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615383190639 | admin@86-ss.com | China | 1000 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9312 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
View Lastest Price from 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-23 | 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
13951-70-7
|
US $100.00-75.00 / kg | 1kg | 99% | 5000Ton | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | ||
2024-09-18 | 16alpha-Hydroxyprednisolone
13951-70-7
|
US $0.00 / kg | 1kg | 99% HPLC | 20 tons | Wuhan Senwayer Century Chemical Co.,Ltd | ||
2024-08-30 | 11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione
13951-70-7
|
US $2460.00 / KG | 500g | 99% | 10000KG | Baoji Guokang Bio-Technology Co., Ltd. |
- 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
13951-70-7
- US $100.00-75.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
- 16alpha-Hydroxyprednisolone
13951-70-7
- US $0.00 / kg
- 99% HPLC
- Wuhan Senwayer Century Chemical Co.,Ltd
- 11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione
13951-70-7
- US $2460.00 / KG
- 99%
- Baoji Guokang Bio-Technology Co., Ltd.
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