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Gonadorelin

Gonadorelin Structure
Gonadorelin structure
CAS No.
33515-09-2
Chemical Name:
Gonadorelin
Synonyms
LHRH;GRH;Gonadoreline;PYR-HWSYGLRPG-NH2;GONADOTROPIN-RELEASING HORMONE;PYR-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2;LRF;C07607;LHRH, HUMAN;GONADORELIN
CBNumber:
CB2706342
Molecular Formula:
C55H75N17O13
Molecular Weight:
1182.31
MDL Number:
MFCD00167538
MOL File:
33515-09-2.mol
Last updated:2024-03-21 17:31:59
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Gonadorelin Properties

Density 1.54
solubility ≥118.2 mg/mL in DMSO with ultrasonic; insoluble in EtOH; ≥28.7 mg/mL in H2O
pka 9.82±0.15(Predicted)
InChIKey XLXSAKCOAKORKW-AQJXLSMYSA-N
FDA UNII 9O7312W37G
ATC code H01CA01,V04CM01

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H360

Gonadorelin price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich G0525000 Gonadorelin European Pharmacopoeia (EP) Reference Standard 33515-09-2 g0525000 $220 2024-03-01 Buy
Sigma-Aldrich 1296803 Gonadorelin 33515-09-2 6.53mg $572 2024-03-01 Buy
ApexBio Technology A1147 Luteinizinghormonereleasinghormonehumanacetatesalt(LHRH) 33515-09-2 1mg $18 2021-12-16 Buy
ApexBio Technology A1147 Luteinizinghormonereleasinghormonehumanacetatesalt(LHRH) 33515-09-2 5mg $54 2021-12-16 Buy
AvaChem 2221 Gonadorelin 33515-09-2 25mg $190 2021-12-16 Buy
Product number Packaging Price Buy
G0525000 g0525000 $220 Buy
1296803 6.53mg $572 Buy
A1147 1mg $18 Buy
A1147 5mg $54 Buy
2221 25mg $190 Buy

Gonadorelin Chemical Properties,Uses,Production

Uses

Gonad-stimulating principle.

Uses

Gonadorein is a Gonadotropin-releasing hormone. Gonadorelin agonist treatment for men with locoregional prostate cancer may be associated with an increased risk of incident diabetes and ardiovascular disease.

Definition

ChEBI: A ten-membered synthetic oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, glycyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence.

brand name

Lutrepulse (Ferring Pharmaceuticals).

Biological Activity

luteinizing hormone releasing hormone human acetate salt (lhrh) is a selective acitivator of mmp-2 and mmp-9 [1, 2].luteinizing hormone-releasing hormone (lhrh), also known as gonadotropin-releasing hormone (gnrh) is a trophic peptide hormone which secreted by gnrh neurons and plays an important role in the release of follicle-stimulating hormone (fsh) and luteinizing hormone (lh) from the anterior pituitary [3].mmp-2 (matrix metalloproteinase-2) and mmp-9 (matrix metalloproteinase-9) belong to the mmp family that play an important role in the breakdown of extracellular matrix (ecm) in normal physiological processes, for example, embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis [2].when tested with ishikawa and ecc-1 cell lines, lhrh resulted in the increase of mmp-9 expression which induced cell invasion and it was also showed that gpr101 mediated the lhrh activity and cooperated to function in the metastatic potential of endometrial cancer cells [1]. in human decidual endometrial stromal cells, lhrh with its receptor induced the activation of mmp-2 and mmp-9 [2].

Side effects

If you experience a rare allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives) to gonadorelin, seek emergency medical attention.
Other less serious side effects may also occur. Notify your doctor if you experience: headache; flushing; nausea or abdominal discomfort; dizziness or lightheadedness; pain, swelling, or itching at the injection site; or skin rash.

Veterinary Drugs and Treatments

Gonadorelin is indicated (approved) for the treatment of ovarian follicular cysts in dairy cattle. Additionally, gonadorelin has been used in cattle to reduce the time interval from calving to first ovulation and to increase the number of ovulations within the first 3 months after calving. This may be particularly important in increasing fertility in cows with retained placenta.
In dogs, gonadorelin has been used experimentally to help diagnose reproductive disorders or to identify intact animals versus castrated ones by maximally stimulating FSH and LH production. It has also been used experimentally in dogs to induce estrus through pulsatile dosing. While apparently effective, specialized administration equipment is required for this method.
Gonadorelin has been used in cats as an alternate therapy to FSH or hCG to induce estrus in cats with prolonged anestrus.
In Europe, a synthetic analogue buserelin has been used in horses to stimulate cyclic estrus. Its efficacy rates poorly when compared to an artificial light program, however.
In human medicine, gonadorelin has been used for the diagnosis of hypothalamic-pituitary dysfunction, cryptorchidism, and depression secondary to prolonged severe stress.

References

[1]. cho-clark, m., et al., gnrh-(1-5) activates matrix metallopeptidase-9 to release epidermal growth factor and promote cellular invasion. mol cell endocrinol, 2015.
[2]. wu, h.m., et al., gonadotropin-releasing hormone type ii (gnrh-ii) agonist regulates the motility of human decidual endometrial stromal cells: possible effect on embryo implantation and pregnancy. biol reprod, 2015. 92(4): p. 98.
[3]. garnick, m.b. and m. campion, abarelix depot, a gnrh antagonist, v lhrh superagonists in prostate cancer: differential effects on follicle-stimulating hormone. abarelix depot study group. mol urol, 2000. 4(3): p. 275-7.

Gonadorelin synthesis

51776-33-1
105823-83-4
33515-09-2
Synthesis of Gonadorelin from H-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2 and L-Tryptophan, N-[N-(5-oxo-L-prolyl)-L-histidyl]-, ethyl ester (9CI)

Gonadorelin Preparation Products And Raw materials

Raw materials

L-Tryptophan, N-[N-(5-oxo-L-prolyl)-L-histidyl]-, ethyl ester (9CI) H-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2

Preparation Products

Gonadorelin Suppliers

Global( 184)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Xunou new energy Technology Co., LTD 		+undefined17531957005 xunou8@hbxunou.com China 36 58
Chengdu Youngshe Chemical Co., Ltd.
+8618108235634 Cecilia@youngshechem.com China 2345 58
Zhejiang Hangyu API Co., Ltd
+8617531972939 anna@api-made.com China 2944 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823 admin@guyunchem.com China 616 58
Henan Tengmao Chemical Technology Co. LTD 		+8615238638457 salesvip2@hntmhg.com China 415 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 994 58
Hebei Anlijie Biotechnology Co., Ltd 		+8619031013551 ably@aljbio.com China 177 58
Shijiazhuang Saixin Technology Co., Ltd. 		+86-16632312509 +86-16632315022 saixinkeji@aliyun.com China 90 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Supplier Advantage
Hebei Xunou new energy Technology Co., LTD 		58
Chengdu Youngshe Chemical Co., Ltd.
58
Zhejiang Hangyu API Co., Ltd
58
Nantong Guangyuan Chemicl Co,Ltd
58
Henan Tengmao Chemical Technology Co. LTD 		58
Anhui Ruihan Technology Co., Ltd 		58
Hebei Anlijie Biotechnology Co., Ltd 		58
Shijiazhuang Saixin Technology Co., Ltd. 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55

View Lastest Price from Gonadorelin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Gonadorelin pictures 2024-04-27 Gonadorelin
33515-09-2
 US $1.00-9.90 / g 1g 99% 1000g Wuhan Cell Pharmaceutical Co., Ltd
Gonadorelin pictures 2024-03-21 Gonadorelin
33515-09-2
 US $110.00-90.00 / kilogram 1kilogram 99% 10 tons/per week Henan Tengmao Chemical Technology Co. LTD
Gonadorelin pictures 2024-03-16 Gonadorelin
33515-09-2
 US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
  • Gonadorelin pictures
  • Gonadorelin
    33515-09-2
  • US $1.00-9.90 / g
  • 99%
  • Wuhan Cell Pharmaceutical Co., Ltd
  • Gonadorelin pictures
  • Gonadorelin
    33515-09-2
  • US $110.00-90.00 / kilogram
  • 99%
  • Henan Tengmao Chemical Technology Co. LTD
  • Gonadorelin pictures
  • Gonadorelin
    33515-09-2
  • US $0.00 / KG
  • 98%+
  • WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Gonadorelin Spectrum

Gonadorelin(33515-09-2)MS

33515-09-2(Gonadorelin)Related Search:

Hydroxypropyl cellulose Inositol Chorionic Gonadotropin Goserelin Goserelin EP Impurity G ((D-His2)-Goserelin)
Goserelin EP Impurity L ((D-Leu7)-Goserelin) Gonadorelin impurity AC-SER-ASP-LYS-PRO-OH LUTEINIZING HORMONE-RELEASING HORMONE (L HRH) SYNTHETIC >9,LHRH (LAMPREY III),Recombinant Human Leutenizing hormone Releasing Hormone(Gonadorelin) Nafarelin Acetate
Triptorelin Gonadorelin acetate Nafarelin GONADORELIN ACETATE (D-Ser(tBu)6,Azagly10)-LHRH acetate salt
luteinizing hormone releasing hormone (D-Trp^<6^>) analog,d-trp(sup6)-pro(sup9)-n-ethylamide-lhr BUSERELIN ((imbl)-d-his(sub6),pro(sub9)-net)lhr

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LUTEINIZING HORMONE RELEASING HORMONE HUMAN LUTEINIZING HORMONE RELEASING HORMONE (HUMAN) PORCINE, RAT LUTEINIZING HORMONE-RELEASING FACTOR (LAMPREY III) LUTEINIZING HORMONE-RELEASING HORMONEACETATE LUTEINIZING HORMONE-RELEASING FACTOR (SEA BREAM) LUTEINIZING HORMONE RELEASING HORMONE LUTEINISING HORMONE RELEASING HORMONE LRF LEUTINIZING HORMONE RELEASING HORMONE LHRH (SEA BREAM) LHRH, HUMAN LH-RH (HUMAN) PORCINE, RAT LHRH (LAMPREY III) LH-RH LUTEINIZING HORMONE-RELEASING HORMONE LH-RH ACETATE GONADOTROPIN-RELEASING HORMONE (SEA BREAM) GONADOTROPIN RELEASING HORMONE ACETATE GONADOTROPIN-RELEASING HORMONE (LAMPREY III) GONADOTROPIN-RELEASING HORMONE (PORCINE, RAT) GONADOLIBERIN ACETATE GONADORELIN GONADORELINE, HUMAN GNRH (PORCINE, RAT) GLP-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2 PGLU-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2 PGLU-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2 ACETATE PYROGLU-HIS-TRP-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2 PYR-HIS-TRP-SER-HIS-ASP-TRP-LYS-PRO-GLY-NH2 Luteinizing hormone-releasing factor (swine) Synthetic gonadotropin-releasing hormone Synthetic luliberin Synthetic luteinizing hormone-releasing factor GONADORELIN ACETATE PH. EUR. LUTEINIZING HORMONE-RELEASING HORMONE (SEA BREAM) LUTENIZING HORMONE RELEASING HORMONE HUMAN LUTEINIZING HORMONE-RELEASING HORMONE (LAMPREY III) LUTEINIZING HORMONE-RELEASING HORMONE (LH-RH), HUMAN Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 acetate salt ginadoliberin GONADERELIN Gonadorelin, GnRH, Luliberin Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 hydrochloride salt M.W. 1182.31 C55H75N17O13 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-Gly-L-Leu-L-Arg-L-Pro-Gly-NH2 Luteinizing hormone-releasing factor【human】 Luteinizing hormone-releasing factor【pig】 C07607 Gonadoliberin i Gonadoliberin, Luliberin (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[[(2-amino-2-oxoethyl)amino]-oxomethyl]-1-pyrrolidinyl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydr Gonadorelin for NMR identification Gonadorelin CRS Pharmaceutical Peptides Peptide Gonadorelin 2vials Lyophilized Powder Gonadorelin USP/EP/BP GonadorelinQ: What is Gonadorelin Q: What is the CAS Number of Gonadorelin Q: What is the storage condition of Gonadorelin Gonadorelin Acetate(net) LHRH