4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
- CAS No.
- 479633-63-1
- Chemical Name:
- 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
- Synonyms
- Tofacitinib Impurity 20;Tofacitinib-9;Tofacitinib imurity;Tofatinib Impurity 1;Tofatinib Impurity P;Tofacitinib Impurity R;Tofacitinib Impurity 53;4-Chloro-7-tosyl-7H-pyrro...;4-Chloro-7-tosyl-7H-pyrrolo[2;Azilsartan medoxomil impurity345
- CBNumber:
- CB32452480
- Molecular Formula:
- C13H10ClN3O2S
- Molecular Weight:
- 307.76
- MDL Number:
- MFCD09907939
- MOL File:
- 479633-63-1.mol
Melting point | 145.0 to 149.0 °C |
---|---|
Boiling point | 505.3±60.0 °C(Predicted) |
Density | 1.49 |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Chloroform (Slightly), DMSO (Slightly) |
form | powder to crystal |
pka | 1.73±0.30(Predicted) |
color | White to Orange to Green |
InChI | InChI=1S/C13H10ClN3O2S/c1-9-2-4-10(5-3-9)20(18,19)17-7-6-11-12(14)15-8-16-13(11)17/h2-8H,1H3 |
InChIKey | BTOJSYRZQZOMOK-UHFFFAOYSA-N |
SMILES | C1=NC(Cl)=C2C=CN(S(C3=CC=C(C)C=C3)(=O)=O)C2=N1 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319 |
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
Hazard Codes | Xn |
Risk Statements | 22 |
HazardClass | IRRITANT |
HS Code | 2933599590 |
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine price More Price(23)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | ADE000077 | 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Aldrich | 479633-63-1 | 1g | $761 | 2023-06-20 | Buy |
TCI Chemical | C3036 | 4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine >96.0%(HPLC)(N) | 479633-63-1 | 1g | $74 | 2024-03-01 | Buy |
TCI Chemical | C3036 | 4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine >96.0%(HPLC)(N) | 479633-63-1 | 5g | $296 | 2023-06-20 | Buy |
Apolloscientific | OR317249 | 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine | 479633-63-1 | 5g | $327 | 2021-12-16 | Buy |
Biosynth Carbosynth | FC10607 | 4-Chloro-7-p-toluenesulphonyl-7H-pyrrolo[2,3-d]pyrimidine | 479633-63-1 | 25g | $472.5 | 2021-12-16 | Buy |
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Uses,Production
Uses
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.
Synthesis
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (2kg, 12.96mol) and dichloromethane (40L) were added to the reaction flask at room temperature, stirred and dissolved. Triethylamine (3.88 kg, 38.4 mol) and 4-dimethylamino pyridine (157.6 g, 1.28 mol) were added in that order, and after stirring and dissolved, p-toluenesulfonyl chloride (2.6 kg, 13.6 mol) was added dropwise at 0 °C. The chloromethane (30 L) solution was added dropwise, and the mixture was stirred at room temperature for 30 min. After the TLC was applied, the mixture was washed with water (16L×3). 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (3.9 kg, yield 97.7%) was obtained after drying under reduced pressure.
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Minbiotech Co., Ltd. | +8617315815539 | sales@minbiotech.com | CHINA | 129 | 58 |
Huanfu Industrial Co.,(Shanghai)Ltd. | +86-18001856580 +86-18001856580 | 2415195517@qq.com | China | 43 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20293 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18629 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 811 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
View Lastest Price from 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-18 | 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
479633-63-1
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-08-28 | Tofacitinib Impurity 1
479633-63-1
|
US $0.00-0.00 / mg | 10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD | ||
2024-04-15 | 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
479633-63-1
|
US $5.00-0.10 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
- 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
479633-63-1
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
- Tofacitinib Impurity 1
479633-63-1
- US $0.00-0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
- 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
479633-63-1
- US $5.00-0.10 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
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