Losmapimod (GW856553X)
- CAS No.
- 585543-15-3
- Chemical Name:
- Losmapimod (GW856553X)
- Synonyms
- CS-1186;GSK-AHAB;SB856553;GW-856553;LosMapiMod;GW 856553X;SB0856553);LosMapiMod,GW-856553;MIS-21394 LOSMAPIMOD;Losmapimod (GW856553X)
- CBNumber:
- CB32484670
- Molecular Formula:
- C22H26FN3O2
- Molecular Weight:
- 383.46
- MDL Number:
- MFCD16619322
- MOL File:
- 585543-15-3.mol
- MSDS File:
- SDS
| Boiling point | 529.4±50.0 °C(Predicted) |
|---|---|
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in EtOH; insoluble in H2O; ≥19.15 mg/mL in DMSO |
| form | solid |
| pka | 7.75±0.46(Predicted) |
| FDA UNII | F2DQF16BXE |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
Losmapimod (GW856553X) price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13614 | GW 856553X ≥98% | 585543-15-3 | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 13614 | GW 856553X ≥98% | 585543-15-3 | 5mg | $67 | 2024-03-01 | Buy |
| Cayman Chemical | 13614 | GW 856553X ≥98% | 585543-15-3 | 10mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 13614 | GW 856553X ≥98% | 585543-15-3 | 25mg | $249 | 2024-03-01 | Buy |
| TRC | L471000 | Losmapimod | 585543-15-3 | 50mg | $340 | 2021-12-16 | Buy |
Losmapimod (GW856553X) Chemical Properties,Uses,Production
Description
GW 856553X is a dual inhibitor of p38α and p38β MAPK (Kis = 0.0079 and 0.025 μM, respectively, in cell-free assays). It is selective for p38α and p38β MAPK over p38γ and p38δ MAPK when used at a concentration of 10 μM. GW 856553X inhibits LPS-induced TNF-α production in isolated rat and human peripheral blood mononuclear cells (PBMCs; IC50s = 0.6 and 0.13 μM, respectively). It decreases disease severity in a mouse model of collagen-induced arthritis when administered at doses ranging from 0.8 to 20 mg/kg. GW 856553X (1.2 and 12 mg/kg) improves survival, normalizes blood pressure, and reduces increases in plasma levels of HDL, LDL, and triglycerides in spontaneously hypertensive stroke-prone rats fed a high-salt high-fat diet.
Uses
Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor.
Definition
ChEBI: 6-[5-[(cyclopropylamino)-oxomethyl]-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide is a phenylpyridine.
target
p38α
References
[1]. willette rn, eybye me, olzinski ar, et al. differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease. j pharmacol exp ther, 2009, 330(3): 964-970.
[2]. cheriyan j, webb aj, sarov-blat l, et al. inhibition of p38 mitogen-activated protein kinase improves nitric oxide-mediated vasodilatation and reduces inflammation in hypercholesterolemia. circulation., 2011, 123(5): 515-523.
[3]. lomas da, lipson da, miller be, et al. an oral inhibitor of p38 map kinase reduces plasma fibrinogen in patients with chronic obstructive pulmonary disease. j clin pharmacol, 2012, 52(3): 416-424.
Losmapimod (GW856553X) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28710 | 58 |
| Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | nutrabiotech@outlook.com | China | 300 | 58 |
View Lastest Price from Losmapimod (GW856553X) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Losmapimod
585543-15-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Losmapimod
585543-15-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-12-24 | Losmapimod (GW856553X)
585543-15-3
|
US $1.00 / g | 1g | 99% | 20kg | Career Henan Chemical Co |
-
- Losmapimod
585543-15-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Losmapimod
585543-15-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Losmapimod (GW856553X)
585543-15-3
- US $1.00 / g
- 99%
- Career Henan Chemical Co