Brinzolamide-d5
- CAS No.
- 1217651-02-9
- Chemical Name:
- Brinzolamide-d5
- Synonyms
- Brinzolamide-d5;[2H5]-Brinzolamide
- CBNumber:
- CB32507883
- Molecular Formula:
- C12H21N3O5S3
- Molecular Weight:
- 383.5
- MDL Number:
- MOL File:
- 1217651-02-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| NFPA 704 |
|
Brinzolamide-d5 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 30006 | Brinzolamide-d5 | 1217651-02-9 | 500μg | $279 | 2024-03-01 | Buy |
| Cayman Chemical | 30006 | Brinzolamide-d5 | 1217651-02-9 | 1mg | $501 | 2024-03-01 | Buy |
| TRC | B677602 | Brinzolamide-d5 | 1217651-02-9 | 5mg | $1980 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | RDL0006690 | BRINZOLAMIDE-D5 95.00% | 1217651-02-9 | 5MG | $2783 | 2021-12-16 | Buy |
| AK Scientific | 7669DG | Brinzolamide-d5 | 1217651-02-9 | 1mg | $646 | 2021-12-16 | Buy |
Brinzolamide-d5 Chemical Properties,Uses,Production
Description
Brinzolamide-d5 is intended for use as an internal standard for the quantification of brinzolamide by GC- or LC-MS. Brinzolamide is a potent inhibitor of carbonic anhydrase II (CAII) and CAIV (IC50s = 3.19 and 45.3 nM, respectively). It is selective for CAII and CAIV over CAI (IC50 = ~1,365 nM). Brinzolamide (30 mg/kg) reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35% in mice. Topical administration of brinzolamide (0.25, 0.5, and 1 mg/eye) reduces intraocular pressure in a rabbit model of spontaneous ocular hypertension. It also reduces intraocular pressure in a cynomolgus monkey model of argon laser trabeculoplasty-induced ocular hypertension. Formulations containing brinzolamide have been used in the treatment of glaucoma and ocular hypertension.
Chemical Properties
Crystalline Solid
Uses
Carbonic anhydrase inhibitor. Antiglaucoma agent.
Brinzolamide-d5 Preparation Products And Raw materials
Raw materials
Preparation Products
Brinzolamide-d5 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Hubei Yangxin Medical Technology Co., Ltd. | 15374522761 | 3003392093@qq.com | China | 7851 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Shanghai isotope chemical co.,ltd | 021-021-51600108 13062666369 | sales@chinaisotope.com | China | 4272 | 58 |
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