1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-
- CAS No.
- 509102-00-5
- Chemical Name:
- 1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-
- Synonyms
- MIM1;CS-1192;MIM 1;MIM-1;Inhibitor of Mcl-1;1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-;4-[[[2-(Cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-1,2,3-benzenetriol;inhibit,Bcl-2 Family,Inhibitor of Mcl1,Inhibitor,MIM-1,MIM1,MIM 1,Inhibitor of Mcl 1;1,2,3-Benzenetriol, 4-[[[2-(cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-
- CBNumber:
- CB32652150
- Molecular Formula:
- C17H21N3O3S
- Molecular Weight:
- 347.43
- MDL Number:
- MFCD25563256
- MOL File:
- 509102-00-5.mol
- MSDS File:
- SDS
1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4- price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19832 | MIM1 ≥98% | 509102-00-5 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19832 | MIM1 ≥98% | 509102-00-5 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 19832 | MIM1 ≥98% | 509102-00-5 | 10mg | $153 | 2024-03-01 | Buy |
| Tocris | 4762 | MIM1 | 509102-00-5 | 50 | $657 | 2021-12-16 | Buy |
| TRC | M341043 | MIM1 | 509102-00-5 | 10mg | $330 | 2021-12-16 | Buy |
1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4- Chemical Properties,Uses,Production
Description
MIM1 is an inhibitor of Mcl-1, an antiapoptotic Bcl-2 family protein with a role in cancer. It selectively engages the canonical groove of Mcl-1, inhibiting its ability to bind BH3 domains (IC50 = 4.7 μM). MIM1 induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells.
Uses
MIM1 binds to MCL-1 and aids in the modulation of cell death, division and differentiation. MIM1 may be used for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders.
References
[1]. cohen na, stewart ml, gavathiotis e, et al. a competitive stapled peptide screen identifies a selective small molecule that overcomes mcl-1-dependent leukemia cell survival. chemistry & biology, 2012, 19(9): 1175-1186.
1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4- Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |