Trioctylphosphine oxide
- CAS No.
- 78-50-2
- Chemical Name:
- Trioctylphosphine oxide
- Synonyms
- TOPO;TOPO(R);(Oct)3PO;CYANEX 921;hostarexpx324;HISHICOLIN PO-8;trioctylphosphinoxide;trioctyl-phosphineoxid;TRIOCTYLPHOSPHINE OXIDE;TrioCLylphosphine oxide
- CBNumber:
- CB3268225
- Molecular Formula:
- C24H51OP
- Molecular Weight:
- 386.63
- MDL Number:
- MFCD00002083
- MOL File:
- 78-50-2.mol
- MSDS File:
- SDS
| Melting point | 50-52 °C(lit.) |
|---|---|
| Boiling point | 201-202 °C2 mm Hg(lit.) |
| Density | 0,88 g/cm3 |
| vapor pressure | 0.004Pa at 50℃ |
| Flash point | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | <1g/l |
| form | Crystalline Powder, Crystals or Flakes |
| color | White to slightly yellow |
| Water Solubility | Insoluble |
| BRN | 1796648 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| LogP | 9.54 |
| CAS DataBase Reference | 78-50-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | EXU8U2AM5A |
| EPA Substance Registry System | Phosphine oxide, trioctyl- (78-50-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H412 | |||||||||
| Precautionary statements | P264-P273-P280-P302+P352-P305+P351+P338-P332+P313 | |||||||||
| Hazard Codes | Xi,Hazard | |||||||||
| Risk Statements | 38-41-50/53-34 | |||||||||
| Safety Statements | 26-36/39-39-61-60-45-36/37/39 | |||||||||
| RIDADR | 3261 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | SZ1662500 | |||||||||
| Autoignition Temperature | 270 °C | |||||||||
| TSCA | Yes | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29310095 | |||||||||
| HS Code | 32019090 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 10000 mg/kg LD50 dermal Rat 2830 mg/kg | |||||||||
| NFPA 704 |
|
Trioctylphosphine oxide price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 223301 | Trioctylphosphine oxide ReagentPlus , 99% | 78-50-2 | 5g | $53.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 00676 | Trioctylphosphine oxide for extraction analysis, ≥98.5% | 78-50-2 | 10g | $98.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.14868 | Trioctylphosphinoxide for synthesis | 78-50-2 | 25g | $51.6 | 2022-05-15 | Buy |
| Sigma-Aldrich | 8.14868 | Trioctylphosphinoxide for synthesis | 78-50-2 | 100g | $204 | 2022-05-15 | Buy |
| TCI Chemical | T0504 | Tri-n-octylphosphine Oxide >95.0%(GC) | 78-50-2 | 25g | $40 | 2024-03-01 | Buy |
Trioctylphosphine oxide Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Catalyst in:
- Preparation of tetradentate planar-chiral hydroxy-substituted ferrocenecarboxaldimine Schiff base ligands
- Reactions of allyl esters with hydrosilanes
- Asymmetric cyanosilylation of aldehydes
- Preparation of chlorothiol formates from thiols and phosgene
Uses
Tri-n-octylphosphine oxide is a solvent used in the extraction of metals, especially uranium, zirconium and hafnium. It is also used as an auxiliary reagent in the solvent extraction of metals. It is also used to extract hydrogen bonding organic compounds. Further, it is useful as a capping ligand for the production of quantum dots, such as those consisting of cadmium selenide.
Uses
Trioctylphosphine oxide (TOPO) is most commonly used as the solvent due to its high boiling point and chemical stability, and its ability to prevent particle aggregation via coordination to the NP surface. trioctylphosphine oxide is a frequently used surfactant, starts to decompose at around 425°C.
The industrial applications of trioctylphosphine oxide, make use of its complexing powers with metals and with hydrogen donor organic compounds. Commercial uses as a solvent extraction reagent are in the recovery of uranium from wet process phosphoric acid and in the recovery of byproduct acetic acid and furfural generated during sulphite wood pulping.
TOPO is a widely used chemical compound in nanocrystal synthesis, for the removal of heavy metals, and the removal of toxins in waste water. TOPO is often used as a ligand stabilizer for colloids in traditional thermal decomposition synthetic techniques.
trioctylphosphine oxide became a nearly irreplaceable solvent (mp 51-52°C) for high-temperature preparation of various type of nanocomposites. TOPO has a very high boiling point (411°C) which is an important prerequisite for the homogeneous nucleation and good crystallinity of the nanoparticles.
General Description
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Flammability and Explosibility
Non flammable
Purification Methods
Mason, McCarty and Peppard [J Inorg Nuclear Chem 24 967 1962] stirred a 0.1M solution in *benzene with an equal volume of 6M HCl at 40o in a sealed flask for 48hours, then washed the *benzene solution successively with water (twice), 5% aqueous Na2CO3 (three times) and water (six times). The *benzene and water were then evaporated under reduced pressure at room temperature. Zingaro and White [J Inorg Nucl Chem 12 315 1960] treated a pet ether solution with aqueous KMnO4 (to oxidise any phosphinous acids to phosphinic acids), then with sodium oxalate, H2SO4 and HCl (to remove any manganese compounds). The pet ether solution was slurried with activated alumina (to remove phosphinic acids), filtered, evaporated and the residue was recrystallised from pet ether or cyclohexane at -20o. It can also be recrystallised from EtOH. [Beilstein 4 IV 3466.]
Trioctylphosphine oxide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5964 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 16805 | 58 |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | bj1@bj-chem.com | China | 298 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 | sales@fluoropharm.com | China | 1377 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Trioctylphosphine oxide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | Trioctylphosphine oxide
78-50-2
|
US $8.00-2.00 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-10-21 | Trioctylphosphine oxide
78-50-2
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-09-26 | Trioctylphosphine oxide
78-50-2
|
US $0.00-0.00 / kg | 1kg | 0.99 | 100tons | Hebei Yanxi Chemical Co., Ltd. |
-
- Trioctylphosphine oxide
78-50-2
- US $8.00-2.00 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Trioctylphosphine oxide
78-50-2
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Trioctylphosphine oxide
78-50-2
- US $0.00-0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.