3-Chlorophenylboronic acid
- CAS No.
- 63503-60-6
- Chemical Name:
- 3-Chlorophenylboronic acid
- Synonyms
- 3-CHLOROBENZENEBORONIC ACID;AKOS BRN-0010;RARECHEM AH PB 0179;3-Chlorophenylboroni;3-Chlorophenylboronic;3-CHLOROPHENYLBORNIC ACID;3-Chlorophenylboroic acid;M-CHLOROPHENYLBORONIC ACID;3-CHLOROPHENYLBORONIC ACID;3-Chlorophenylboornic acid
- CBNumber:
- CB3486386
- Molecular Formula:
- C6H6BClO2
- Molecular Weight:
- 156.37
- MDL Number:
- MFCD00161354
- MOL File:
- 63503-60-6.mol
Melting point | 185-189 °C(lit.) |
---|---|
Boiling point | 311.4±44.0 °C(Predicted) |
Density | 1.32±0.1 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | soluble in Methanol |
pka | 7.55±0.10(Predicted) |
form | Crystalline Powder or Needles |
color | White to light yellow-green |
Water Solubility | Slightly soluble in water. soluble in ether, tetrahydrofuran,, dimethyl sulfoxide, dimethyl formamide, methanol. |
BRN | 2936343 |
InChI | InChI=1S/C6H6BClO2/c8-6-3-1-2-5(4-6)7(9)10/h1-4,9-10H |
InChIKey | SDEAGACSNFSZCU-UHFFFAOYSA-N |
SMILES | B(C1=CC=CC(Cl)=C1)(O)O |
CAS DataBase Reference | 63503-60-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302+H312+H332 | |||||||||
Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
Hazard Codes | Xn,Xi | |||||||||
Risk Statements | 20/21/22-36/37/38 | |||||||||
Safety Statements | 36-37/39-26 | |||||||||
WGK Germany | 3 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29163990 | |||||||||
NFPA 704 |
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3-Chlorophenylboronic acid price More Price(41)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 417521 | 3-Chlorophenylboronic acid ≥95% | 63503-60-6 | 1g | $35.4 | 2024-03-01 | Buy |
Sigma-Aldrich | 417521 | 3-Chlorophenylboronic acid ≥95% | 63503-60-6 | 10g | $202 | 2024-03-01 | Buy |
TCI Chemical | C1613 | 3-Chlorophenylboronic Acid (contains varying amounts of Anhydride) | 63503-60-6 | 5g | $31 | 2024-03-01 | Buy |
TCI Chemical | C1613 | 3-Chlorophenylboronic Acid (contains varying amounts of Anhydride) | 63503-60-6 | 25g | $121 | 2024-03-01 | Buy |
Alfa Aesar | B24444 | 3-Chlorobenzeneboronic acid, 97% | 63503-60-6 | 1g | $20.65 | 2024-03-01 | Buy |
3-Chlorophenylboronic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow-green crystalline powder
Uses
suzuki reaction
Uses
Reactant involved in:
- 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides
- Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene
- Cross-coupling reactions with diazoesters or potassium cyanate
- Synthesis of biarylketones and phthalides
- Synthesis of inhibitors including PDE4 inhibitors among others
Uses
3-Chlorophenylboronic acid is employed as a reactant involved in 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides, Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene, cross-coupling reactions with diazoesters3 or potassium cyanate. It is involved in the synthesis of biarylketones and phthalides and synthesis of inhibitors including PDE4 inhibitors6 among others.
Synthesis
Using m-dichlorobenzene as the starting material, iodine particles and 1,2-dibromoethane as the initiator reacts with magnesium in an organic solvent to prepare 3-chlorophenyl magnesium chloride. Then, the trimethyl borate is reacted with an organic solvent to prepare 3-chlorophenyl borate dimethyl ester. Finally, the product 3-chlorophenylboronic acid is obtained through hydrolysis, extraction, and crystallization.
Solubility in organics
3-Chlorophenylboronic acid can be dissolved in organic solvents such as N, N-dimethylformamide, ethyl acetate, and dichloromethane. In addition, it also has specific solubility in low-polarity and non-polar organic solvents, but 3-chlorophenylboronic acid has poor solubility in water.
3-Chlorophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 7193 | 58 |
Hebei Maison Chemical Co.,Ltd. | +8615511852758 | sales@maisonchem.com.cn | China | 484 | 58 |
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. | +86-18616643091 +86-18616643091 | info@rochipharma.com | China | 246 | 58 |
Zhengzhou Lingzhiyue Technology Co., Ltd | +86-0371-55074660 +86-13783527580 | Lingzhiyue@aliyun.com | China | 3152 | 58 |
Cangzhou Kangrui Pharma Tech Co. Ltd., | +8618632776803 | cangzhoukangrui@126.com | China | 733 | 58 |
Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1090 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20291 | 58 |
Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | info@spring-chem.com | China | 2068 | 57 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
View Lastest Price from 3-Chlorophenylboronic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-25 | 3-Chlorophenylboronic acid
63503-60-6
|
US $471.00 / kg | 1kg | 0.98 | 100kg | Shanghai UCHEM Inc. | ||
2024-04-08 | 3-Chlorophenylboronic acid
63503-60-6
|
US $34.00-1.20 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | ||
2023-12-02 | 3-Chlorophenylboronic acid
63503-60-6
|
US $0.00-0.00 / kg | 1kg | 99.9% | 30000 Kg | Hebei Xinsheng New Material Technology Co., LTD. |
- 3-Chlorophenylboronic acid
63503-60-6
- US $471.00 / kg
- 0.98
- Shanghai UCHEM Inc.
- 3-Chlorophenylboronic acid
63503-60-6
- US $34.00-1.20 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
- 3-Chlorophenylboronic acid
63503-60-6
- US $0.00-0.00 / kg
- 99.9%
- Hebei Xinsheng New Material Technology Co., LTD.