Docetaxel trihydrate
- CAS No.
- 148408-66-6
- Chemical Name:
- Docetaxel trihydrate
- Synonyms
- Xrp6976;Taxespira;Unii-15H5577cqd;DOCETAXEL HYDRATE;Docetaxel (200 mg);Taxotere Trihydrate;Docetaxel (1224551);Docetaxel trihydrate;Docetaxel Tryhydrate;Docetaxel(trihydrous)
- CBNumber:
- CB3511420
- Molecular Formula:
- C43H55NO15
- Molecular Weight:
- 825.91
- MDL Number:
- MOL File:
- 148408-66-6.mol
- MSDS File:
- SDS
Melting point | 186-192°C |
---|---|
storage temp. | 2-8°C |
solubility | Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in methylene chloride. |
form | Solid |
color | White to OFf-White |
Stability | Hygroscopic |
InChIKey | XCDIRYDKECHIPE-KHDBCEGQSA-N |
CAS DataBase Reference | 148408-66-6(CAS DataBase Reference) |
FDA UNII | 15H5577CQD |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS08 |
---|---|
Signal word | Danger |
Hazard statements | H319-H360F |
Precautionary statements | P202-P264-P280-P305+P351+P338-P308+P313-P337+P313 |
WGK Germany | 3 |
HS Code | 2932996560 |
Docetaxel trihydrate price More Price(26)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PHR1883 | Docetaxel trihydrate | 148408-66-6 | 200mg | $342 | 2024-03-01 | Buy |
Sigma-Aldrich | 1224551 | Docetaxel for system suitability | 148408-66-6 | 200mg | $3550 | 2024-03-01 | Buy |
Sigma-Aldrich | Y0001155 | Docetaxel for system suitability European Pharmacopoeia (EP) Reference Standard | 148408-66-6 | y0001155 | $153 | 2024-03-01 | Buy |
Sigma-Aldrich | Y0001133 | Docetaxel trihydrate European Pharmacopoeia (EP) Reference Standard | 148408-66-6 | y0001133 | $220 | 2024-03-01 | Buy |
Usbiological | 447603 | Docetaxel Trihydrate | 148408-66-6 | 5mg | $496 | 2021-12-16 | Buy |
Docetaxel trihydrate Chemical Properties,Uses,Production
Pharmacology
Docetaxel principally exerts its cytotoxic activity by promoting and stabilising microtubule assembly while simultaneously preventing microtubule depolymerisation. This results in inhibition of normal cell division. In vitro and in vivo, docetaxel has antineoplastic activity against a wide range of cancer cells, demonstrates synergistic activity with several antineoplastic agents and often has greater cytotoxic activity against human breast cancer cell lines than paclitaxel. Docetaxel, binds to and stabilizes tubulin, which prevents physiological microtubule depolymerization/disassembly and results in cell-cycle arrest at the G2/M phase and cell death. This agent also is known to inhibit the anti-apoptotic gene Bcl2 and to encourage the expression of p27, a cell-cycle inhibitor, and further pro-angiogenic factors such as vascular endothelial growth factor (VEGF). Docetaxel is mainly metabolized in the liver by the cytochrome P450 CYP3A4 and CYP3A5 subfamilies of isoenzymes, and its clearance has been shown to be related to body surface area and hepatic enzyme and alpha1 acid glycoprotein plasma levels.
Tolerability
The tolerability of docetaxel in comparative clinical trials was generally acceptable. Severe neutropenia affects most docetaxel recipients, with febrile neutropenia occurring in approximately one-eighth of patients. Dose-cumulative severe fluid retention was reported in docetaxel recipients, despite premedication with prophylactic corticosteroids. Other adverse events include asthenia, stomatitis, infections, neurosensory, cutaneous or gastrointestinal events, nail changes, severe fever in the absence of infection, myalgia and hypersensitivity reactions.
Chemical Properties
White Crystalline Powder
Uses
An antineoplastic. An antimitotic agent that promotes the assembly of microtublules and inhibits their depolymerization to free tubulin
Uses
Docetaxel Trihydrate is an anti-cancer drugs; Semisynthetic analog of the taxane paclitaxel.
Definition
ChEBI: The trihydrate form of docetaxel. It is used for the treatment of breast, ovarian, and non-small cell lung cancer, and with prednisone or prednisolone in hormone-refractory metastatic prostate cancer.
brand name
Taxotere (Sanofi Aventis).
Docetaxel trihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21666 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9294 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Jiangsu Yew Pharmaceutical Co., Ltd. | +86-510-66865338 +86-189-2133-5032 @ | junwenjiang@live.cn | CHINA | 30 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 | sales04@yibaibiotech.com | CHINA | 419 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Related articles
- What is Docetaxel trihydrate?
- Docetaxel (Taxotere?), a cytotoxic taxane, is an antimicrotubule agent effective in the treatment of patients with breast canc....
- Feb 10,2020
View Lastest Price from Docetaxel trihydrate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-07-13 | Docetaxel (Trihydrate)
148408-66-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2021-07-09 | Docetaxel (Trihydrate)
148408-66-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2019-07-06 | Docetaxel trihydrate
148408-66-6
|
US $1.00 / KG | 1G | 98% | 100KG | Career Henan Chemical Co |
- Docetaxel (Trihydrate)
148408-66-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Docetaxel (Trihydrate)
148408-66-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Docetaxel trihydrate
148408-66-6
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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