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Paclitaxel

Indications and Usage Mechanisms of Action Warnings and Precautions
Paclitaxel
Paclitaxel
CAS No.
33069-62-4
Chemical Name:
Paclitaxel
Synonyms
TAXOL;taxal;EMPAC;Onxal;TAXUS;CL183;Capxol;NK 105;taxol a;ABI 007
CBNumber:
CB3273425
Molecular Formula:
C47H51NO14
Formula Weight:
853.91
MOL File:
33069-62-4.mol

Paclitaxel Properties

Melting point:
213 °C (dec.)(lit.)
alpha 
D20 -49° (methanol)
Boiling point:
774.66°C (rough estimate)
Density 
0.200
refractive index 
-49 ° (C=1, MeOH)
Flash point:
9℃
storage temp. 
2-8°C
solubility 
methanol: 50 mg/mL, clear, colorless
form 
powder
color 
white
λmax
227nm(MeOH)(lit.)
Merck 
14,6982
Stability:
Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKey
RCINICONZNJXQF-MZXODVADSA-N
CAS DataBase Reference
33069-62-4(CAS DataBase Reference)
EPA Substance Registry System
Benzenepropanoic acid, .beta.-(benzoylamino)-.alpha.- hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S, 12aR,12bS)-6,12b-bis(acetyloxy)- 12-(benzoyloxy)-2a,3,4,4a, 5,6,9,10,11,12,12a,12b-dodecahydro- 4,11-dihydroxy-4a,8,13,13- tetramethyl-5-oxo-7,11-methano- 1H-cyclodeca[3,4]benz[1,2- b]oxet-9-yl ester, (.alpha.R,.beta.S)-(33069-62-4)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  37/38-41-42/43-62-68-40-48-20/21/22-68/20/21/22
Safety Statements  22-26-36/37/39-45
RIDADR  1544
WGK Germany  3
RTECS  DA8340700
10-21
HazardClass  6.1(b)
PackingGroup  III
Hazardous Substances Data 33069-62-4(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H371 May cause damage to organs Specific target organ toxicity, single exposure Category 2 Warning P260, P264, P270, P309+P311, P405,P501
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P201 Obtain special instructions before use.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P405 Store locked up.

Paclitaxel price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 580555 Paclitaxel 33069-62-4 5mg $91.5 2017-11-08 Buy
Sigma-Aldrich 1491332 Paclitaxel United States Pharmacopeia (USP) Reference Standard 33069-62-4 200mg $3350 2017-11-08 Buy
TCI Chemical P1632 Paclitaxel >98.0%(HPLC) 33069-62-4 100mg $476 2017-12-01 Buy
Alfa Aesar J62734 Paclitaxel, 99.5+% 33069-62-4 1g $609 2017-11-08 Buy
Alfa Aesar J62734 Paclitaxel, 99.5+% 33069-62-4 100mg $110 2017-11-08 Buy

Paclitaxel Chemical Properties,Uses,Production

Indications and Usage

Paclitaxel is a monomeric diterpene compound extracted from Chinese yew bark and is a complicated secondary metabolite. Stage II-III clinical studies show that paclitaxel is most suitable for ovarian and breast cancer, and has certain efficacy in treating prostate cancer, lung cancer, colorectal cancer, melanoma, head and neck cancer, esophageal cancer, germ cell tumors, endometrial cancer, lymphoma, brain tumors, bladder cancer, upper gastrointestinal cancer, small cell and non-small cell lung cancer.

Mechanisms of Action

Paclitaxel is currently the only known drug that can promote microtubule polymerization and stabilize polymerized microtubules. It can only form on polymerized microtubules and does not react with non-polymerized microtubule protein dipolymers. After coming in contact with paclitaxel, cells will accumulate a large number of microtubules within themselves, which disrupts cell functions, especially cell division, which is forced to cease at the mitotic stage.

Warnings and Precautions

1. Hermatological toxicity: the main factor in increased dosage limitations; when white blood cells are below 1500/mm3, supplement with G-CSF; when platelets are below 30000/mm3, transfuse component blood.
2. Allergic reaction: Aside from preconditions, if there are only minor symptoms such as flushed face, skin reactions, slightly increase heart rate, slightly lowered blood pressure, etc., do not stop treatment and decrease injection speed. If there are serious reactions such as hypotension, vascular edema, difficulty breathing, measles, etc., stop treatment and treat accordingly. Patients with serious allergic reactions should not use paclitaxel in the future.
3. Nervous system: Common reactions include numb toes. Approximately 4% patients, especially with high dosage, experience significant sensory and motor difficulty and decreased tendon reflex. There have been individual reports of epilepsy.
4. Cardiovascular: Transient tachycardia and hypotension are common and do not usually require attention. However, monitor closely during first hour of injection. Afterwards, only patients with serious injection difficulty require hourly check-ins.
5. Join and muscle: Approximately half of the patients will experience some joint and muscle pain within the first 2-3 days following injection, which is related to dosage, and usually subsides after a couple days. Patients who are also administered G-CSF will experience heightened muscle pain.
6. Liver and gall: As paclitaxel is mainly excreted through bile, patients with liver and gall diseases must be monitored carefully. Among thousands of cases, 8% of patients experienced increased bilirubin, 23% experienced increased alkaline phosphatase, and 18% experienced increased glutamic-oxalacetic transaminase. However, there is currently no evidence indicating that paclitaxel causes any severe liver damage.
7. Other: Digestive tract reactions are common but rarely severe, with few cases of diarrhea and mucosa infection. Slight alopecia is also common.

Chemical Properties

White Powder

Uses

glucocorticoid, antiinflammatory

Uses

An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanc ed forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.

Uses

Tool in study of structure and function of microtubules.

General Description

Needles (from aqueous methanol) or fine white powder. An anti-cancer drug.

Air & Water Reactions

May be sensitive to prolonged exposure to moisture. .

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Flash point data for Paclitaxel are not available. Paclitaxel is probably combustible.

Biological Activity

Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.

Paclitaxel Preparation Products And Raw materials

Raw materials

Preparation Products


Paclitaxel Suppliers

Global( 518)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jiangsu Yew Pharmaceutical Co., Ltd.
+86-510-66865338 +86-181-6838-3188 jiangwenjun@hongdou.com
+86-510-66865972 junwenjiang@live.cn , jiangwenjun@hongdou.com CHINA 15 60
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 382 50
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 887 50
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3229 55
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 299 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20808 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32766 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2549 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 2952 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales1@fine-chemtech.com CHINA 894 55

View Lastest Price from Paclitaxel manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-13 Paclitaxel
33069-62-4
US $10.00 / KG 1KG 99% 100 MT per month -
2018-07-25 Paclitaxel
33069-62-4
US $100.00 / G 10G 99% 500kg/month -
2018-07-24 Paclitaxel
33069-62-4
US $1000.00 / KG 1KG 98% 10ton

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