AY 9944
- CAS No.
- 366-93-8
- Chemical Name:
- AY 9944
- Synonyms
- AY 9944;trans-id;AY99442HCl;AY 9944 dihydrochlor;AY 9944 DIHYDROCHLORIDE;AY 9944 - CAS 366-93-8 - Calbiochem;TRANS-1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE, 2HCL;1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE;trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexanedihydrochloride;trans1,4-bis(2-dichlorobenzylaminoethyl)cyclohexanedichlorhydrate
- CBNumber:
- CB3673047
- Molecular Formula:
- C22H30Cl4N2
- Molecular Weight:
- 464.3
- MDL Number:
- MFCD01734586
- MOL File:
- 366-93-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | Xi,N | |||||||||
| Risk Statements | 36/37/38-50/53 | |||||||||
| Safety Statements | 26-60-61 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GU7025000 | |||||||||
| HazardClass | 6.1 | |||||||||
| Toxicity | LD50 orl-mus: 155 mg/kg PSEBAA 139,100,72 | |||||||||
| NFPA 704 |
|
AY 9944 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S693162 | 1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE Aldrich | 366-93-8 | 5mg | $110 | 2024-03-01 | Buy |
| Sigma-Aldrich | 190080 | AY 9944 | 366-93-8 | 5mg | $230 | 2024-03-01 | Buy |
| Alfa Aesar | J65079 | AY 9944 dihydrochloride | 366-93-8 | 50mg | $896 | 2023-06-20 | Buy |
| Cayman Chemical | 14611 | AY 9944 ≥98% | 366-93-8 | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 14611 | AY 9944 ≥98% | 366-93-8 | 5mg | $100 | 2024-03-01 | Buy |
AY 9944 Chemical Properties,Uses,Production
Uses
Inhibitor of hedgehog (Hh) signaling
Uses
Cholesterol synthesis inhibitor; inhibits both 7-dehydrocholesterol 7-reductase and 8,7-sterol isomerase. A sonic hedgehog inhibitor
Biological Activity
Inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ 7 -dehydrocholesterol reductase (IC 50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo .
Safety Profile
Poison by ingestion.Experimental teratogenic and reproductive effects.Inhibits cholesterol synthesis. When heated todecomposition it emits very toxic fumes of NOx and Cl-.
storage
room temperature (desiccate)
References
[1]. moebius, f.f., et al., molecular cloning and expression of the human delta7-sterol reductase. proc natl acad sci u s a, 1998. 95(4): p. 1899-902.
[2]. achour, a., et al., restoration of immune response by a cationic amphiphilic drug (ay 9944) in vitro: a new approach to chemotherapy against human immunodeficiency virus type 1. antimicrob agents chemother, 1998. 42(10): p. 2482-91.
[3]. xu, l., et al., novel oxysterols observed in tissues and fluids of ay9944-treated rats: a model for smith-lemli-opitz syndrome. j lipid res, 2011. 52(10): p. 1810-20.
AY 9944 Preparation Products And Raw materials
Raw materials
Preparation Products
AY 9944 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55791 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Jiangsu yize medical technology co. LTD | 18550739526 | 3394205705@qq.com | China | 9408 | 58 |
| Shanghai Puluokai Medical Technology Co., LTD | 17269768198 | prochemx@163.com | China | 613 | 58 |