ANTIBIOTIC UCN-02
- CAS No.
- 121569-61-7
- Chemical Name:
- ANTIBIOTIC UCN-02
- Synonyms
- UCN-02;UCN02,UCN 02;ANTIBIOTIC UCN-02;9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-, (3S,9S,10R,11R,13R)-
- CBNumber:
- CB42446750
- Molecular Formula:
- C28H26N4O4
- Molecular Weight:
- 482.53
- MDL Number:
- MFCD32174062
- MOL File:
- 121569-61-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| NFPA 704 |
|
ANTIBIOTIC UCN-02 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20221 | UCN-02 ≥95% | 121569-61-7 | 1mg | $299 | 2024-03-01 | Buy |
| Cayman Chemical | 20221 | UCN-02 ≥95% | 121569-61-7 | 5mg | $1121 | 2024-03-01 | Buy |
| Usbiological | A2297-39A | Antibiotic UCN-02 | 121569-61-7 | 1mg | $523 | 2021-12-16 | Buy |
| ApexBio Technology | C4829 | UCN-02 | 121569-61-7 | 5mg(solution) | $1432 | 2021-12-16 | Buy |
| ApexBio Technology | C4829 | UCN-02 | 121569-61-7 | 1mg(solution) | $408 | 2021-12-16 | Buy |
ANTIBIOTIC UCN-02 Chemical Properties,Uses,Production
Description
UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01 first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. UCN-02 inhibits protein kinase C with a slightly reduced potency than UCN-01 (IC50 = 62 and 4.1 nM, for UNC-02 and UCN-01, respectively) and is cytotoxic to the growth of HeLa S3 cells.
Uses
UCN-02 is an antibiotic and an indolocarbazole isolated from a high staurosporine-producing?Streptomyces?culture. Related analogs of staurosporine which is non-specific protein kinase inhibitor.
Uses
UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.
References
[1] takahashi, i. ,saitoh, y.,yoshida, m., et al. ucn-01 and ucn-02, new selective inhibitors of protein kinase c. ii. purification, physico-chemical properties, structural determination and biological activities. j.antibiot.(tokyo) 42(4), 571-576 (1989).
[2] newton a c. protein kinase c: structure, function, and regulation[j]. journal of biological chemistry, 1995, 270(48): 28495-28498.
ANTIBIOTIC UCN-02 Preparation Products And Raw materials
Raw materials
Preparation Products
ANTIBIOTIC UCN-02 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
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