ENIPORIDE
- CAS No.
- 176644-21-6
- Chemical Name:
- ENIPORIDE
- Synonyms
- CS-1337;CS-1941;ENIPORID;EMD 96785;ENIPORIDE;Eniporide(EMD96785);EMD 96785,ENIPORIDE;EMD-96785;EMD 96785;N-Carbamimidoyl-2-methyl-5-(methylsulfonyl);N-CarbaMiMidoyl-2-Methyl-5-(Methylsulfonyl)-4-(1H-pyrrol-1-yl)benzaMide
- CBNumber:
- CB42448961
- Molecular Formula:
- C14H16N4O3S
- Molecular Weight:
- 320.37
- MDL Number:
- MFCD08690425
- MOL File:
- 176644-21-6.mol
- MSDS File:
- SDS
| Density | 1.41±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | ≤5mg/ml in DMSO;20mg/ml in dimethyl formamide |
| form | crystalline solid |
| pka | 10.63±0.46(Predicted) |
| FDA UNII | 7IGF9182QU |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
ENIPORIDE price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20984 | Eniporide ≥95% | 176644-21-6 | 1mg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 20984 | Eniporide ≥95% | 176644-21-6 | 5mg | $176 | 2024-03-01 | Buy |
| Cayman Chemical | 20984 | Eniporide ≥95% | 176644-21-6 | 10mg | $311 | 2024-03-01 | Buy |
| Cayman Chemical | 20984 | Eniporide ≥95% | 176644-21-6 | 25mg | $638 | 2024-03-01 | Buy |
| ApexBio Technology | C3709 | Eniporide | 176644-21-6 | 25mg | $705 | 2021-12-16 | Buy |
ENIPORIDE Chemical Properties,Uses,Production
Description
Eniporide is a selective inhibitor of human Na+/H+ exchanger isoform 1 (NHE-1) (IC50 = 4.5 nM). Inhibition with eniporide prevents calcium overload-induced myocardial ischemia-reperfusion injury in vitro and in vivo.
in vitro
eniporide was identified as a selective inhibitor of na+-h+ exchange and a compound of the benzoylguanidine group. in addition, eniporide and its metabolite were found to inhibit the na+-h+ exchange in acidified rabbit erythrocytes with an ic50 value of 4.7 ± 0.6 and 15 ± 3 nm, respectively [1].
in vivo
animal study showed that the pretreatment of the mice with the eniporide led to a substantial decrease of annexin-v–positive cardiomyocytes in the i/r 30/90 group from 20.2% to 2.2%. moreover, the pretreatment of i/r 30/90 mice with eniporide resulted in the complete absence of igg-positive cells, suggesting that the cardiomyocytes with extensive cell membrane leakage were a result of an active cell death program [2].
IC 50
4.7 nm
References
[1] bhattaram va, nagaraja nv, peters t, machnig t, kroesser s, kovar a, derendorf h. population pharmacokinetics of eniporide and its metabolite in healthy subjects and patients with acute myocardial infarction. j clin pharmacol. 2005 jun;45(6):631-9.
[2] dumont ea et al. cardiomyocyte death induced by myocardial ischemia and reperfusion: measurement with recombinant human annexin-v in a mouse model. circulation. 2000 sep 26;102(13):1564-8.
ENIPORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
