- ENIPORIDE
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- $9.80 / 1.79999995231628KG
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2020-01-13
- CAS:176644-21-6
- Min. Order: 1g
- Purity: ≥99%
- Supply Ability: 100kg
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| | ENIPORIDE Basic information |
| Product Name: | ENIPORIDE | | Synonyms: | ENIPORIDE;EMD 96785;N-(Aminoiminomethyl)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide;N-(Diaminomethylene)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide;N-(diaMinoMethylidene)-2-Methyl-5-Methylsulfonyl-4-pyrrol-1-ylbenzaMide;N-CarbaMiMidoyl-2-Methyl-5-(Methylsulfonyl)-4-(1H-pyrrol-1-yl)benzaMide;ENIPORID;EMD 96785,ENIPORIDE | | CAS: | 176644-21-6 | | MF: | C14H16N4O3S | | MW: | 320.37 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 176644-21-6.mol |  |
| | ENIPORIDE Chemical Properties |
| density | 1.41±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | ≤5mg/ml in DMSO;20mg/ml in dimethyl formamide | | form | crystalline solid | | pka | 10.63±0.46(Predicted) |
| | ENIPORIDE Usage And Synthesis |
| Description | Eniporide is a selective inhibitor of human Na+/H+ exchanger isoform 1 (NHE-1) (IC50 = 4.5 nM). Inhibition with eniporide prevents calcium overload-induced myocardial ischemia-reperfusion injury in vitro and in vivo. | | in vitro | eniporide was identified as a selective inhibitor of na+-h+ exchange and a compound of the benzoylguanidine group. in addition, eniporide and its metabolite were found to inhibit the na+-h+ exchange in acidified rabbit erythrocytes with an ic50 value of 4.7 ± 0.6 and 15 ± 3 nm, respectively [1]. | | in vivo | animal study showed that the pretreatment of the mice with the eniporide led to a substantial decrease of annexin-v–positive cardiomyocytes in the i/r 30/90 group from 20.2% to 2.2%. moreover, the pretreatment of i/r 30/90 mice with eniporide resulted in the complete absence of igg-positive cells, suggesting that the cardiomyocytes with extensive cell membrane leakage were a result of an active cell death program [2]. | | IC 50 | 4.7 nm | | references | [1] bhattaram va, nagaraja nv, peters t, machnig t, kroesser s, kovar a, derendorf h. population pharmacokinetics of eniporide and its metabolite in healthy subjects and patients with acute myocardial infarction. j clin pharmacol. 2005 jun;45(6):631-9.
[2] dumont ea et al. cardiomyocyte death induced by myocardial ischemia and reperfusion: measurement with recombinant human annexin-v in a mouse model. circulation. 2000 sep 26;102(13):1564-8. |
| | ENIPORIDE Preparation Products And Raw materials |
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