KU-0063794
- CAS No.
- 938440-64-3
- Chemical Name:
- KU-0063794
- Synonyms
- CS-28;KU0063794;KU 0063794, >=98%;KU0063794(KU63794);KU-0063794 USP/EP/BP;Pholcodine Impurity 8;KU-0063794(KU 0063794);mTOR Inhibitor IV, Ku-63794;KU-0063794;KU 0063794; KU0063794;mTOR Inhibitor IV Ku-63794 Ku63794
- CBNumber:
- CB42468008
- Molecular Formula:
- C25H31N5O4
- Molecular Weight:
- 465.54
- MDL Number:
- MFCD11977741
- MOL File:
- 938440-64-3.mol
- MSDS File:
- SDS
Boiling point | 694.3±65.0 °C(Predicted) |
---|---|
Density | 1.248 |
storage temp. | 2-8°C |
solubility | DMSO: >2mg/mL (warmed) |
form | powder |
pka | 14.20±0.10(Predicted) |
color | white to beige |
InChIKey | RFSMUFRPPYDYRD-CALCHBBNSA-N |
FDA UNII | 81HJG228AB |
KU-0063794 price More Price(39)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0382 | KU 0063794 ≥98% (HPLC) | 938440-64-3 | 5mg | $163 | 2024-03-01 | Buy |
Sigma-Aldrich | 475990 | mTOR Inhibitor IV, Ku-63794 | 938440-64-3 | 5mg | $289 | 2024-03-01 | Buy |
Cayman Chemical | 13597 | KU 0063794 ≥98% | 938440-64-3 | 5mg | $73 | 2024-03-01 | Buy |
Cayman Chemical | 13597 | KU 0063794 ≥98% | 938440-64-3 | 10mg | $138 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0382 | KU 0063794 ≥98% (HPLC) | 938440-64-3 | 25mg | $525 | 2024-03-01 | Buy |
KU-0063794 Chemical Properties,Uses,Production
Description
The mammalian target of rapamycin (mTOR) is a serine-
Uses
Ku 0063794 is a specific mammalian target of rapamycin (mTOR) inhibitor and may be used for the treatment of cancers.
Uses
KU 0063794 has been used:
- as a mammalian target of rapamycin (mTOR) inhibitor to study the effects of follicular stimulating hormone (FSH) in mTOR phosphorylation and vascular cell adhesion molecule-1 (VCAM-1) expression in?human umbilical vascular endothelial cells (HUVECs)
- as a mTOR inhibitor to treat effector memory (EM) CD8+ T cells for metabolic flux analysis
- as an autophagy inducer to demonstrate the utility of p62 and LC3B-II quantification in HEK293T cells and primary cultures of rat neurons and astrocytes using time-resolved fluorescence resonance energy transfer (TR-FRET)
Definition
ChEBI: A member of the class of pyridopyrimidines that is an mTOR inhibitor and shows anti-tumour properties.
Biological Activity
Selective inhibitor of mammalian target of rapamycin (mTOR) (IC 50 ~10 nM for mTORC1 and mTORC2 respectively). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G 1 cell cycle arrest in vitro .
Biochem/physiol Actions
KU 0063794 induces autophagy. It is cell-permeant and suppresses activation and hydrophobic motif phosphorylation of protein kinase B (Akt), p70 ribosomal S6 kinase (S6K) and serum and glucocorticoid protein kinase (SGK).
storage
Room temperature
KU-0063794 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23555 | 58 |
View Lastest Price from KU-0063794 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-07-06 | KU-0063794
938440-64-3
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
- KU-0063794
938440-64-3
- US $2.00 / kg
- 99%
- Career Henan Chemical Co