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CC0651

CC0651 Structure
CC0651 structure
CAS No.
1319207-44-7
Chemical Name:
CC0651
Synonyms
CC0651;CC0651,CC-0651;(2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid;4,5-Dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-L-arabinonic acid;L-Arabinonic acid, 4,5-dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-
CBNumber:
CB42627678
Molecular Formula:
C20H21Cl2NO6
Molecular Weight:
442.29
MDL Number:
MOL File:
1319207-44-7.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17
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CC0651 Properties

Boiling point 755.7±60.0 °C(Predicted)
Density 1.410±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: ≥ 56 mg/mL (126.61 mM)
pka 3.37±0.34(Predicted)
form Powder

CC0651 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 5.09704 Cdc34 Inhibitor, CC0651 - CAS 1319207-44-7 - Calbiochem A cell-permeable, selective allosteric inhibitor of E2 ubiquitin-conjugating enzyme Cdc34 (IC?? = 2.5 μM in a Sic1-SCFCdc4 assay). 1319207-44-7 10MG $240 2023-06-20 Buy
TRC C263475 CC0651 1319207-44-7 2.5mg $435 2021-12-16 Buy
TRC C263475 CC0651 1319207-44-7 1mg $215 2021-12-16 Buy
ChemScene CS-2109 CC0651 99.52% 1319207-44-7 5mg $1176 2021-12-16 Buy
ChemScene CS-2109 CC0651 99.52% 1319207-44-7 10mg $1800 2021-12-16 Buy
Product number Packaging Price Buy
5.09704 10MG $240 Buy
C263475 2.5mg $435 Buy
C263475 1mg $215 Buy
CS-2109 5mg $1176 Buy
CS-2109 10mg $1800 Buy

CC0651 Chemical Properties,Uses,Production

General Description

A cell-permeable biphenylylpentanoic acid compound that acts as a selective allosteric inhibitor of E2 ubiquitin-conjugating enzyme Cdc34 (IC50 = 2.5 μM in a Sic1-SCFCdc4 assay) without affecting the activities of E1 or E3 ligases. Reported to act by trapping a weak interaction between ubiquitin and the E2 donor ubiquitin-binding site and may serve as a molecular bridge between Cdc34A and ubiquitin. Binds to Cdc34ACAT alone with an EC50 value of 267 μM, but in the presence of ubiquitin, this affinity is significantly increased (EC50 = 19 μM). Does not disrupt the interaction of Cdc34A with the RING domain of Rbx1 and is suggested to even moderately stabilize this interaction. Shown to inhibit p27Kip1 ubiquitination (IC50 = 1.72 μM) and reduce PC-3 cancer cells proliferation (~30 μM).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes

CC0651 Preparation Products And Raw materials

Raw materials

Preparation Products

CC0651 Suppliers

Global( 36)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4863 58
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
SPIRO PHARMA eric_feng1954@126.com China 9254 55
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195 505721671@qq.com China 3868 58
Musechem +1-800-259-7612 info@musechem.com United States 4662 60
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
LETOPHARM LIMITED 58
SPIRO PHARMA 55
Guangzhou QiYun Biotechnology Co., Ltd. 58
Musechem 60
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58

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L-Arabinonic acid, 4,5-dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]- CC0651 4,5-Dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-L-arabinonic acid (2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid CC0651,CC-0651 1319207-44-7 C20H21Cl2NO6