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ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID structure

CAS No.: 31842-01-0

Chemical Name:: ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID

Synonyms: k4277;flosin;Praxis;flosint;Bor-ind;Reumofe;isindone;Reumofene;INDOPROFEN;Aids025462

CBNumber:: CB4297426

Molecular Formula:: C17H15NO3

Molecular Weight:: 281.31

MDL Number:: MFCD00057144

MOL File:: 31842-01-0.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:21

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ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID Properties

Melting point	213-214°
Boiling point	423.97°C (rough estimate)
Density	1.1302 (rough estimate)
refractive index	1.4500 (estimate)
storage temp.	2-8°C
solubility	Methanol (Slightly, Sonicated)
pka	pKa 5.8 (Uncertain)
FDA UNII	CPE46ZU14N
ATC code	M01AE10

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06,GHS08
Signal word	Danger
Hazard statements	H301-H351
Precautionary statements	P201-P301+P310+P330
Hazard Codes	T
Risk Statements	25-40
Safety Statements	22-36/37/39-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
RTECS	MU6645000
Toxicity	LD50 in rats (mg/kg): 58.66 i.v.; 60.83 orally (Buttinoni)

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	I3132	Indoprofen analytical standard	31842-01-0	1g	$40.5	2022-05-15	Buy
TRC	I645000	Indoprofen	31842-01-0	10mg	$110	2021-12-16	Buy
TRC	I645000	Indoprofen	31842-01-0	250mg	$715	2021-12-16	Buy
American Custom Chemicals Corporation	API0008560	INDOPROFEN 95.00%	31842-01-0	1G	$525	2021-12-16	Buy
AK Scientific	X6838	Indoprofen	31842-01-0	100mg	$495	2021-12-16	Buy

Product number	Packaging	Price	Buy
I3132	1g	$40.5	Buy
I645000	10mg	$110	Buy
I645000	250mg	$715	Buy
API0008560	1G	$525	Buy
X6838	100mg	$495	Buy

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID Chemical Properties,Uses,Production

Chemical Properties

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID is Off-White Solid

Originator

Flosint,Carlo Erba,Italy,1976

Uses

analgesic, antiinflammatory

Uses

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID is a non-steroidal anti-inflammatory agent used for treatment of pain and inflammation

Definition

ChEBI: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causi g severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.

Manufacturing Process

The mixture of 7.9 g of ethyl α-(4-aminophenyl)propionate and 8.3 g of ethyl 2-chloromethylbenzoate is refluxed under nitrogen for one hour. The residue is recrystallized from hexane, to yield the ethyl α-[4-(1-oxo-isoindolino)-phenyl]- propionate of the formulamelting at 104° to 106°C. The mixture of 4.5 g thereof, 1.6 g of potassiumhydroxide, 2 ml of water and 250 ml of ethanol is refluxed under nitrogen for 2 hours and evaporated under reduced pressure. The residue is taken up in water, the solution washed with chloroform, acidified with hydrochloric acid and extracted with ethyl acetate. The extract is dried, evaporated and the residue recrystallized from ethyl acetate, to yield the corresponding free acid melting at 208° to 210°C. (Procedure reported in US Patent 3,767,805.)

brand name

Endyne;Fenint;Flogosan;Flosine;Flosyn;K 4277;Miantor.

Therapeutic Function

Antiinflammatory

World Health Organization (WHO)

Indoprofen, a nonsteroidal anti-inflammatory agent, was introduced in 1976 for the treatment of rheumatic disorders. By 1983 its use had been associated with serious adverse effects, some of which were fatal. This led to its withdrawal in the United Kingdom and Cyprus. In 1984 reports of intestinal tumours in rats led to the drug's temporary withdrawal in Germany and Italy. This was followed immediately by the suspension of marketing worldwide by the major manufacturer.

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID synthesis

Synthesis of ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID from Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methyl-, ethyl ester

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID Preparation Products And Raw materials

Raw materials

Ethyl 2-chloromethylbenzoate Potassium hydroxide Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methyl-, ethyl ester Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methyl-, methyl ester Benzeneacetic acid, 4-(1,3-dihydro-2H-isoindol-2-yl)-α-methyl-, ethyl ester

1H-Isoindol-1-one, 2-(4-chlorophenyl)-2,3-dihydro- 4-aminohydratropic acid ethyl 2-(4-aminophenyl)propionate 2-(4-NITROPHENYL)PROPIONIC ACID ethyl 2-(4-nitrophenyl)propionate

ZINC carbon monoxide Carbon dioxide 2-Carboxybenzaldehyde

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Preparation Products

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID Suppliers

Global( 74)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
DONBOO AMINO ACID COMPANY	+8613063595538	donboo@donboo.com	China	9365	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94838	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Hangzhou FandaChem Co.,Ltd.	55
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
DONBOO AMINO ACID COMPANY	58
J & K SCIENTIFIC LTD.	76
Chemsky（shanghai）International Co.,Ltd.	50

View Lastest Price from ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-03-06	ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID 31842-01-0	US $1.00 / KG	1KG	99%	200kg	Career Henan Chemical Co

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID
31842-01-0
US $1.00 / KG
99%
Career Henan Chemical Co

31842-01-0(ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID)Related Search:

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DL-INDOLE-3-LACTIC ACID INDOMETHACIN ACYL-B-D-GLUCURONIDE 3-INDOXYL SULFATE POTASSIUM SALT Indole Ibuprofen

4-(DIMETHYLAMINO)PHENYLACETIC ACID 4-(DIMETHYLAMINO)PHENETHYL ALCOHOL ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID dexindoprofen Actarit

Indobufen 4-ISOPROPYLACETANILIDE 4-Aminophenylacetic acid

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ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID 1-oxo-2-(p-((alpha-methyl)carboxymethyl)phenyl)isoindoline 2-(4-(1-carboxyethyl)phenyl)-1-isoindolinone 2-(p-(1-oxo-2-isoindolinyl)phenyl)-propionicaci 4-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-alpha-methyl-benzeneaceticaci 4-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-alpha-methylbenzeneaceticacid alpha-(4-(1-oxo-2-isoindolinyl)phenyl)-propionicaci alpha-(4-(1-oxo-2-iso-indolinyl)-phenyl)-propionicacid flosin INDOPROFEN flosint isindone k4277 p-(1-oxo-2-isoindolinyl)-hydratropicaci p-(1-oxo-2-isoindolinyl)-hydratropicacid α-methyl-p-(1-oxo-2-isoindolinyl)benzeneacetic acid 1-Oxo-2-[p-[(a-methyl)carboxymethyl]phenyl]isoindoline 2-[4-(1-Oxo-2-isoindolinyl)phenyl]propanoic Acid 4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-a-methylbenzeneacetic Acid Bor-ind Praxis Reumofe Indoprofen Solution, 100ppm 2-[p-(1-Oxo-2-isoindolinyl)phenyl]propionic acid 4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-α-methylbenzeneacetic acid Aids025462 Aids-025462 Reumofene Indoprofen,α-Methyl-p-(1-oxo-2-isoindolinyl)benzeneacetic acid 2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid (+/-) Indoprof 1-Oxo-2-[p-[(α-Methyl)carboxyMethyl]phenyl]isoindoline Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methyl- (±)-Indoprofe inhibit,Indoprofen,Inhibitor Indoprofen Indoprofen 31842-01-0 Analytical Chromatography Product Catalog Alphabetic Analytical Standards Pharmaceuticals Aromatics Heterocycles Intermediates & Fine Chemicals