4-Aminophenylacetic acid
- CAS No.
- 1197-55-3
- Chemical Name:
- 4-Aminophenylacetic acid
- Synonyms
- 2-(4-AMINOPHENYL)ACETIC ACID;H-4-APH-OH;P-AMINOPHENYLACETIC ACID;NSC 7929;H-APH(4)-OH;4-AMino acid;p-Amino-alph;Desacetyl Actarit;AKOS BBS-00006880;Phenylglycine base
- CBNumber:
- CB6373122
- Molecular Formula:
- C8H9NO2
- Molecular Weight:
- 151.16
- MDL Number:
- MFCD00007916
- MOL File:
- 1197-55-3.mol
- MSDS File:
- SDS
Melting point | 201 °C (dec.) (lit.) |
---|---|
Boiling point | 273.17°C (rough estimate) |
Density | 1.2023 (rough estimate) |
refractive index | 1.5635 (rough estimate) |
Flash point | 201°C |
storage temp. | Store below +30°C. |
pka | pK1: 3.60;pK2: 5.26 (20°C) |
form | Powder |
color | Light yellow to beige |
Water Solubility | Very soluble in water. |
Decomposition | 201 ºC |
Merck | 14,463 |
BRN | 2208094 |
LogP | 0.220 (est) |
CAS DataBase Reference | 1197-55-3(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 1IED47A544 |
NIST Chemistry Reference | Benzeneacetic acid, 4-amino-(1197-55-3) |
EPA Substance Registry System | Benzeneacetic acid, 4-amino- (1197-55-3) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
Hazard Codes | Xi,Xn | |||||||||
Risk Statements | 36/37/38-20/21/22 | |||||||||
Safety Statements | 22-24/25-36-26 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | AF3550000 | |||||||||
F | 13 | |||||||||
TSCA | Yes | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29224995 | |||||||||
Toxicity | mouse,LD50,intraperitoneal,3500mg/kg (3500mg/kg),Farmaco, Edizione Scientifica. Vol. 13, Pg. 286, 1958. | |||||||||
NFPA 704 |
|
4-Aminophenylacetic acid price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | A71352 | 4-Aminophenylacetic acid 98% | 1197-55-3 | 25g | $88.2 | 2024-03-01 | Buy |
Sigma-Aldrich | A71352 | 4-Aminophenylacetic acid 98% | 1197-55-3 | 100g | $303 | 2023-06-20 | Buy |
TCI Chemical | A0393 | 4-Aminophenylacetic Acid >98.0%(HPLC)(T) | 1197-55-3 | 25g | $100 | 2024-03-01 | Buy |
Alfa Aesar | A14675 | 4-Aminophenylacetic acid, 98% | 1197-55-3 | 10g | $32.65 | 2024-03-01 | Buy |
Alfa Aesar | A14675 | 4-Aminophenylacetic acid, 98% | 1197-55-3 | 50g | $114.65 | 2024-03-01 | Buy |
4-Aminophenylacetic acid Chemical Properties,Uses,Production
Chemical Properties
light yellow to beige powder. Soluble in alcohols and alkalis, slightly soluble in hot water.
Uses
4-Aminophenylacetic acid is used as a non-translocated competitive inhibitor of the epithelial peptide transporter PepT1. It can be detected using HPLC, NMR techniques.
Preparation
p-aminophenylacetic acid is obtained by the reduction of 4-nitrophenylacetic acid. In a reactor, water, 4-nitrophenylacetic acid, and acetic acid are added. The mixture is stirred and heated to 90-95℃. Iron powder is added in portions and refluxed for 2 hours. The mixture is cooled to 40-50℃ and neutralized with sodium carbonate to pH=9, then filtered. The filtrate is further neutralized with acetic acid until pH=4, resulting in the precipitation of 4-aminophenylacetic acid. The yield is 95%.
benefits
4-Aminophenylacetonitrile (4-APAN) is an arylacetonitrile and an active substrate for arylacetonitrilase, which gives 4-aminophenylacetic acid (4-APAA) on hydrolysis. 4-APAA is a precursor of 4-acetylaminophenylacetic acid, used in treating rheumatoid arthritis and actarit drugs. 4-APAA also possesses tuberculostatic activity and is helpful as a fibrinolysis inhibitor. In addition to the medical importance of this acid, several derivatives and compounds obtained from 4-APAA showed antimicrobial activity[1].
Purification Methods
Crystallise the acid from hot water (60-70mL/g). [Beilstein 14 III 1182.]
References
[1] Neerja Thakur. “Bioprocess Development for the Synthesis of 4-Aminophenylacetic Acid Using Nitrilase Activity of Whole Cells of Alcaligenes faecalis MTCC 12629.” Catalysis Letters 149 10 (2019): 2854–2863.
References
[1] BEDAIRAHMED H. Preparation of 4-aminophenylacetic acid derivatives with promising antimicrobial activity.[J]. Acta Pharmaceutica, 2006, 56 3: 273-284.
[2] MENGYIFAN ZareRichard N GnanamaniElumalai. One-Step Formation of Pharmaceuticals Having a Phenylacetic Acid Core Using Water Microdroplets.[J]. Journal of the American Chemical Society, 2023, 145 14: 7724-7728. DOI:10.1021/jacs.3c00773.
4-Aminophenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1of4
Supplier | Tel | Country | ProdList | Advantage | |
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Shanghai Xinchem Co., Ltd. | +86-021-34123252 +8618049800532 | xinchem@xinchem.com | China | 49 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5882 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20292 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 925 | 58 |
View Lastest Price from 4-Aminophenylacetic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-23 | 4-Aminophenylacetic acid
1197-55-3
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | ||
2024-01-14 | (4-Aminophenyl)acetic acid
1197-55-3
|
US $5.00-0.50 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | ||
2023-10-22 | 4-Aminophenylacetic acid
1197-55-3
|
US $0.00-0.00 / drums | 1drums | 98.5%min. | 10tons | Shanghai Xinchem Co., Ltd. |
- 4-Aminophenylacetic acid
1197-55-3
- US $5.00-2.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
- (4-Aminophenyl)acetic acid
1197-55-3
- US $5.00-0.50 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
- 4-Aminophenylacetic acid
1197-55-3
- US $0.00-0.00 / drums
- 98.5%min.
- Shanghai Xinchem Co., Ltd.
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