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NSC781406

NSC781406 structure

CAS No.: 1676893-24-5

Chemical Name:: NSC781406

Synonyms: NSC781406;NSC-781406;NSC 781406;NSC781406;NSC-781406;NSC 781406;NSC781406,Phosphoinositide 3-kinase,NSC 781406,NSC-781406,PI3K,Mammalian target of Rapamycin,Inhibitor,inhibit,mTOR;Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-[3-[4-(methylsulfonyl)-1-piperazinyl]-1-propyn-1-yl]-6-quinolinyl]-3-pyridinyl]-

CBNumber:: CB43334188

Molecular Formula:: C29H27F2N5O5S2

Molecular Weight:: 627.68

MDL Number:

MOL File:: 1676893-24-5.mol

Last updated:2023-05-21 10:59:17

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NSC781406 Properties

Boiling point	775.1±70.0 °C(Predicted)
Density	1.52±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 10mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
form	A solid
pka	6.23±0.40(Predicted)

NSC781406 price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	29226	NSC 781406	1676893-24-5	1mg	$32	2024-03-01	Buy
Cayman Chemical	29226	NSC 781406	1676893-24-5	10mg	$261	2024-03-01	Buy
Cayman Chemical	29226	NSC 781406	1676893-24-5	5mg	$139	2024-03-01	Buy
ChemScene	CS-6958	NSC781406 99.91%	1676893-24-5	10mg	$200	2021-12-16	Buy
AK Scientific	5398EJ	2,4-Difluoro-N-[2-methoxy-5-[4-[3-(4-methylsulfonylpiperazin-1-yl)prop-1-ynyl]quinolin-6-yl]pyridin-3-yl]benzenesulfonamide	1676893-24-5	5mg	$252	2021-12-16	Buy

Product number	Packaging	Price	Buy
29226	1mg	$32	Buy
29226	10mg	$261	Buy
29226	5mg	$139	Buy
CS-6958	10mg	$200	Buy
5398EJ	5mg	$252	Buy

NSC781406 Chemical Properties,Uses,Production

Description

NSC 781406 is a dual inhibitor of PI3K and mammalian target of rapamycin (mTOR; IC₅₀s = 2.0, 9.4, 2.7, 14, and 5.4 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR, respectively). It inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI₅₀ = 65 nM). NSC 781406 (30 mg/kg) reduces tumor volume in a BEL-7404 hepatic cancer mouse xenograft model.

NSC781406 Preparation Products And Raw materials

Raw materials

Preparation Products

NSC781406 Suppliers

Global( 34)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4153	55
YouCoChem (Beijing) Chemical Technology Co., Ltd.	18800159827	youcochem@163.com	China	161	50
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8012	62
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9747	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
InvivoChem	58
Aladdin Scientific	58
Shanghai Boyle Chemical Co., Ltd.	55
MedChemexpress LLC	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
YouCoChem (Beijing) Chemical Technology Co., Ltd.	50
ShangHai Biochempartner Co.,Ltd	62
Shanghai Chaolan Chemical Technology Center	58

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NSC781406 NSC781406;NSC-781406;NSC 781406 NSC-781406;NSC 781406 Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-[3-[4-(methylsulfonyl)-1-piperazinyl]-1-propyn-1-yl]-6-quinolinyl]-3-pyridinyl]- NSC781406,Phosphoinositide 3-kinase,NSC 781406,NSC-781406,PI3K,Mammalian target of Rapamycin,Inhibitor,inhibit,mTOR 1676893-24-5 C29H27F2N5O5S2