ChemicalBook >> CAS DataBase List >>L-655,708
L-655,708
- CAS No.
- 130477-52-0
- Chemical Name:
- L-655,708
- Synonyms
- MSD;L-655,708;L 655708,L655708;ETHYL (S)-11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLATE;Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate;11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1.5-a]pyrrolo[2.1-c][1.4]benzodiazepine-1-carboxylicacidethylester;Ethyl (S)-7-methoxy-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate;(S)-ethyl 7-methoxy-9-oxo-11,12,13,13a- tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate;11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLIC ACID, ETHYL ESTER;9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)-
- CBNumber:
- CB4345633
- Molecular Formula:
- C18H19N3O4
- Molecular Weight:
- 341.36
- MDL Number:
- MFCD02684528
- MOL File:
- 130477-52-0.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:55:09
Melting point | 175-176 °C |
---|---|
Boiling point | 584.4±50.0 °C(Predicted) |
Density | 1.42±0.1 g/cm3(Predicted) |
storage temp. | Desiccate at +4°C |
solubility | DMSO: 6 mg/mL |
form | powder |
pka | 1.49±0.20(Predicted) |
color | White to yellow |
FDA UNII | L4BX842T8C |
L-655,708 price More Price(22)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | L9787 | L-655,708 ≥98% (HPLC), powder | 130477-52-0 | 5mg | $131 | 2024-03-01 | Buy |
Sigma-Aldrich | L9787 | L-655,708 ≥98% (HPLC), powder | 130477-52-0 | 25mg | $522 | 2024-03-01 | Buy |
Cayman Chemical | 30322 | L-655,708 | 130477-52-0 | 5mg | $106 | 2024-03-01 | Buy |
Cayman Chemical | 30322 | L-655,708 | 130477-52-0 | 50mg | $570 | 2024-03-01 | Buy |
Cayman Chemical | 30322 | L-655,708 | 130477-52-0 | 10mg | $167 | 2024-03-01 | Buy |
L-655,708 Chemical Properties,Uses,Production
Uses
L-655,708 has been used as an α5 GABAA receptor inverse agonist to inhibit the discriminative stimulus of propofol in a dose-dependent manner.
Biological Activity
Potent, selective inverse agonist for the benzodiazepine site of GABA A receptors containing the α 5 subunit (K i = 0.45 nM). Displays 50-100-fold selectivity over GABA A receptors containing α 1, α 2, α 3 or α 6 subunits in combination with β 3 and γ 2. Enhances LTP in? a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.
Biochem/physiol Actions
L-655,708 is an inverse agonist of the α5 γ-Aminobutyric acid type A (GABAA) receptor. It has an ability to increase cognition in rats.
storage
Desiccate at +4°C
L-655,708 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 68)Suppliers
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ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
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Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)-
9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)- (011-14426_500Mg)
MSD
Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate
11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1.5-a]pyrrolo[2.1-c][1.4]benzodiazepine-1-carboxylicacidethylester
11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLIC ACID, ETHYL ESTER
L-655,708
ETHYL (S)-11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLATE
(S)-ethyl 7-methoxy-9-oxo-11,12,13,13a-
tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate
L 655708,L655708
Ethyl (S)-7-methoxy-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate
130477-52-0
GABA/Glycine receptor