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MELITTIN

MELITTIN structure

CAS No.: 20449-79-0

Chemical Name:: MELITTIN

Synonyms: C11198;forapin;forapine;melitten;MELITTIN;MELLITIN;melittini;melittin(major);beevenommelittin;honeybeemelittin

CBNumber:: CB4388272

Molecular Formula:: C131H229N39O31

Molecular Weight:: 2846.46

MDL Number:: MFCD00076868

MOL File:: 20449-79-0.mol

MSDS File:: SDS

Last updated:2024-04-24 17:21:45

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MELITTIN Properties

alpha	D21 -89.52° (c = 0.409)
Density	1.39
storage temp.	-20°C
solubility	Soluble to 1 mg/ml in 20% acetonitrile
form	White to faint tan powder.
Water Solubility	Soluble to 1 mg/ml in water
Sequence	H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
InChIKey	VDXZNPDIRNWWCW-JFTDCZMZSA-N
EWG's Food Scores	1
FDA UNII	24VT8NVE75

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301+H311
Precautionary statements	P264-P270-P280-P301+P310-P302+P352+P312-P361+P364
Hazard Codes	T
Risk Statements	23/24/25
Safety Statements	36-45-36/37/39
RIDADR	UN 3462 6.1/PG 1
WGK Germany	3
RTECS	OS3965000
F	10-21

MELITTIN price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	M4171	Melittin ≥97% (HPLC), synthetic	20449-79-0	250μg	$511	2024-03-01	Buy
Sigma-Aldrich	M2272	Melittin from honey bee venom ≥85% (HPLC)	20449-79-0	1mg	$83.3	2024-03-01	Buy
Sigma-Aldrich	M2272	Melittin from honey bee venom ≥85% (HPLC)	20449-79-0	5mg	$280	2024-03-01	Buy
Cayman Chemical	17494	Melittin	20449-79-0	500μg	$107	2023-06-20	Buy
Cayman Chemical	17494	Melittin	20449-79-0	5mg	$796	2023-06-20	Buy

Product number	Packaging	Price	Buy
M4171	250μg	$511	Buy
M2272	1mg	$83.3	Buy
M2272	5mg	$280	Buy
17494	500μg	$107	Buy
17494	5mg	$796	Buy

MELITTIN Chemical Properties,Uses,Production

Uses

Melittin has been used in standard bacterium-killing assay to determine bactericidal activity and study the role of melittin in allergic reactions.

Uses

Melittin from honey bee venom has been used:

In 3-(4, 5-dimethyl thiazol-2-yl)-2,5diphenyl tetrazolium bromide (MTT) assay to determine its cytotoxicity effect on the growth of human cell lines.
To study the anti-microbial activity of melittin on the growth of Borrelia burgdorferi in in vitro conditions.
As a positive control in hemolysis assay and as a cytotoxic agent against HeLa cells.

Definition

ChEBI: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active com onent of bee venom.

General Description

Chemical structure: peptide

Biochem/physiol Actions

Melittin acts as an anti-coagulating protein by increasing the time of blood clotting in vitro. Melittin inhibits the activity of S100 calcium-binding protein B (S100B) and plays a vital role in Epilepsy treatment. Melittin retard cathepsin S-induced invasion, proliferation and angiogenesis via inhibition of the vascular endothelial growth factor A (VEGF-A) /VEGF receptor 2 (VEGFR-2)/ mitogen-activated protein kinase 1 (MEK1)/ extracellular signal-regulated kinase 1/2 (ERK1/2) pathway in human MHCC97-H cells (liver cancer cells). Melittin has therapeutic application in various inflammatory diseases such as skin inflammation, neuroinflammation, atherosclerosis, arthritis and liver inflammation. Accumulated melittin degrades phospholipid packing in the cell membrane and causes cell lysis and cell death.

storage

Store at -20°C

MELITTIN synthesis

Synthesis of MELITTIN from Fmoc-Gly-OH and FMOC-L-Valine and Fmoc-Leu-OH and FMOC-Ala-OH and Fmoc-Pro-OH and Fmoc-Ile-OH and Nalpha-FMOC-L-Tryptophan and 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-butanoic acid and FMOC-LYS-OH and Fmoc-L-Serine and Nalpha-FMOC-L-Glutamine and FMOC-L-Arginine

MELITTIN Preparation Products And Raw materials

Raw materials

FMOC-L-Arginine Nalpha-FMOC-L-Glutamine FMOC-Ala-OH FMOC-LYS-OH Fmoc-Pro-OH

FMOC-L-Valine Fmoc-Leu-OH 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-butanoic acid Fmoc-L-Serine Nalpha-FMOC-L-Tryptophan

Fmoc-Ile-OH Fmoc-Gly-OH

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Preparation Products

MELITTIN Suppliers

Global( 182)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Shanghai Yunao International Trade Co., Ltd	+8617621705551	asdf@shanghaihg.cn	China	265	58
Henan Tengmao Chemical Technology Co. LTD	+8615238638457	salesvip2@hntmhg.com	China	415	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	951	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	841	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58

Supplier	Advantage
Henan Bao Enluo International TradeCo.，LTD	58
Shanghai Yunao International Trade Co., Ltd	58
Henan Tengmao Chemical Technology Co. LTD	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
hebei hongtan Biotechnology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58

View Lastest Price from MELITTIN manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-30	Melittin 20449-79-0	US $30.00 / box	1box	98%	2000kg	hebei hongtan Biotechnology Co., Ltd
2024-04-24	Melittin 20449-79-0	US $50.00 / g	1g	99%	100kg/week	Hebei Zhuanglai Chemical Trading Co.,Ltd
2024-01-14	Melittin 20449-79-0	US $0.10-0.30 / kg	1kg	>98%	20 tons	Zibo Hangyu Biotechnology Development Co., Ltd

Melittin
20449-79-0
US $30.00 / box
98%
hebei hongtan Biotechnology Co., Ltd

Melittin
20449-79-0
US $50.00 / g
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

Melittin
20449-79-0
US $0.10-0.30 / kg
>98%
Zibo Hangyu Biotechnology Development Co., Ltd

MELITTIN Spectrum

MELITTIN(20449-79-0)MS

20449-79-0(MELITTIN)Related Search:

PROPOLIS EXTRACT FROM PENNSYLVANIA 4-NITRO-3-(OCTANOYLOXY)BENZOIC ACID MELITTIN Honey CECROPIN A (1-8)-MELITTIN A (3-9) AMIDE,CECROPIN A (1-7)-MELITTIN A (2-9) AMIDE,CECROPIN A-MELITTIN HYBRID PEPTIDE

CECROPIN A (1-8)-MELITTIN (1-18) AMIDE MELITTIN,MELITTIN (FREE ACID) MELITTIN SYNTHETIC >99% BEE VENOM POLYPE PTIDE MELITTIN(MELLITIN) MELITTIN,MELITTIN (NATURAL),melittin-

(5-aminopentanoyl)melittin (4-aminobutanoyl)melittin Melittin b BIOTINYL-MELITTIN cecropin A(1-8)melittin(1-2)

cecropin A(1-7)melittin(2-9) cecropin A(1-8)melittin(1-18) melittin(8-26)

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beevenommelittin forapin forapine Gly-L-Ile-Gly-L-Ala-L-Val-L-Leu-L-Lys-L-Val-L-Leu-L-Thr-L-Thr-Gly-L-Leu-L-Pro-L-Ala-L-Leu-L-Ile-L-Ser-L-Trp-L-Ile-L-Lys-L-Arg-L-Lys-L-Arg-L-Gln-L-Gln-NH2 Gly-L-Ile-Gly-L-Ala-L-Val-L-Leu-L-Lys-L-Val-L-Leu-L-Thr-L-Thr-Gly-L-Leu-L-Pro-L-Ala-L-Leu-L-Ile-L-Ser-L-Trp-L-Ile-L-Lys-L-Arg-L-Lys-L-Arg-L-Glu(NH2)-L-Glu(NH2)-NH2 GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2: GIGAVLKVLTTGLPALISWIKRKRQQ-NH2 C11198 melittin from honey bee venom BeeVenomCrystalline BeeVenomLyophilised honeybeemelittin melitten melittin(apiscerana) melittin(honeybee) melittin(major) melittini MELITTIN (NATURAL) MELITTIN MELLITIN GIGAVLKVLTTGLPALISWIKRKRQQ-NH2 GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2 H-GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2 Melittin, ≥97% (HPLC) MELITTIN USP/EP/BP Melittin (honeybee) (9CI, ACI) L-Glutamamide, glycyl-L-isoleucylglycy 20449-79-0 C131H229N39O31 Biochemicals and Reagents Calcium Antagonists Cell Biology Cell Signaling and Neuroscience Chelators Intracellular Calcium Signaling Proteomics and Protein Expression Protein Analysis Protein Sequencing Standards for Protein Sequencing Enzyme Inhibitors Enzyme Inhibitors by Type Enzymes, Inhibitors, and Substrates BioChemical Amino Acids Calcium Antagonists Cell Signaling and Neuroscience Intracellular Calcium Signaling