Pleuromulin
- CAS No.
- 125-65-5
- Chemical Name:
- Pleuromulin
- Synonyms
- bc757;a4014c;Tymosin;NSC 121145;PLEUROMULIN;drosopholinb;Drosophilin B;PLEUROMUTILIN;antibioticbc757;Truncate pleurotin
- CBNumber:
- CB4436641
- Molecular Formula:
- C22H34O5
- Molecular Weight:
- 378.5
- MDL Number:
- MFCD28154633
- MOL File:
- 125-65-5.mol
| Melting point | 170-1710C |
|---|---|
| alpha | D24 +20° (c = 3 in abs ethanol) |
| Boiling point | 482.8±45.0 °C(Predicted) |
| Density | 1.15±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMSO: >10mg/mL (warmed) |
| form | powder |
| pka | 12.91±0.10(Predicted) |
| color | white to beige |
| optical activity | [α]/D +30 to +40° (c=1; CH2Cl2) |
| InChIKey | YSBXUHAJXRCCET-BKUNHTPHSA-N |
| FDA UNII | 3DE4A80MZ1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H410 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P391-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MC5408000 | |||||||||
| Toxicity | LD50 in mice: >60 mg/kg (Kavanagh, 1952) | |||||||||
| NFPA 704 |
|
Pleuromulin price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0285 | Pleuromutilin ≥95% | 125-65-5 | 5mg | $144 | 2024-03-01 | Buy |
| Sigma-Aldrich | Y0000586 | Valnemulin impurity E European Pharmacopoeia (EP) Reference Standard | 125-65-5 | y0000586 | $223 | 2024-03-01 | Buy |
| Cayman Chemical | 19452 | Pleuromutilin ≥98% | 125-65-5 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 19452 | Pleuromutilin ≥98% | 125-65-5 | 10mg | $176 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0285 | Pleuromutilin ≥95% | 125-65-5 | 25mg | $568 | 2024-03-01 | Buy |
Pleuromulin Chemical Properties,Uses,Production
Description
Pleuromutilin is an antibiotic derived from the fungus Clitopilus that inhibits bacterial protein synthesis by binding to bacterial ribosomes in the peptidyl transferase component of the 50S subunit and inhibiting peptide bond formation.
Chemical Properties
Pleuromulin is Crystalline Solid
Uses
Antibiotic substance produced by the basidiomycetes Pleurotus mutilus.
Uses
Pleuromutilin is a diterpene produced by several species of basidomycete, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Pleuromutilin inhibits protein synthesis by binding to domain V of 23S rRNA and this has led to the development of many semi-synthetic analogues as new generation antibiotics, such as tiamulin and retapamulin.
Pleuromutilins such as tiamulin and valnemulin have been used for some time in veterinary medicine to treat swine infections. More recently a semisynthetic pleuromutilin, retapamulin, has been introduced as a topical treatment for Gram-positive infections in humans. Pleuromutilins inhibit the peptidyl transferase activity of the bacterial 50S ribosomal subunit by binding to the A site.
References
[1]. kilaru s, collins cm, hartley aj, et al. establishing molecular tools for genetic manipulation of the pleuromutilin-producing fungus clitopilus passeckerianus. appl environ microbiol. 2009 nov;75(22):7196-204.
[2]. long ks, hansen lh, jakobsen l, et al. interaction of pleuromutilin derivatives with the ribosomal peptidyl transferase center. antimicrob agents chemother. 2006 apr;50(4):1458-62.
Pleuromulin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
View Lastest Price from Pleuromulin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-08-30 | antibioticbc757
125-65-5
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2021-12-22 | Pleuromulin
125-65-5
|
US $10.00 / Kg/Bag | 10g | 99 | 1000KG | Wuhan Demeikai Biotechnology Co., Ltd | |
 |
2021-09-04 | Pleuromulin
125-65-5
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Guanlang Biotechnology Co., Ltd. |
-
- antibioticbc757
125-65-5
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Pleuromulin
125-65-5
- US $10.00 / Kg/Bag
- 99
- Wuhan Demeikai Biotechnology Co., Ltd
-
- Pleuromulin
125-65-5
- US $10.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.