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4-Methoxyphenylacetic acid

CAS No.
104-01-8
Chemical Name:
4-Methoxyphenylacetic acid
Synonyms
P-METHOXYPHENYLACETIC ACID;HOMOANISIC ACID;ASISCHEM D13364;HOMO-P-ANISIC ACID;RARECHEM AL BO 0133;p-Anisylacetic acid;4-Methoxyphenylaceti;p-Methioxy-toluicacid;4-Methoxyphenylacetic;LABOTEST-BB LT00848110
CBNumber:
CB5113770
Molecular Formula:
C9H10O3
Molecular Weight:
166.17
MDL Number:
MFCD00004345
MOL File:
104-01-8.mol
MSDS File:
SDS
Last updated:2023-09-12 17:26:57

4-Methoxyphenylacetic acid Properties

Melting point 84-86 °C(lit.)
Boiling point 140 °C3 mm Hg(lit.)
Density 1.1708 (rough estimate)
vapor pressure 0.071Pa at 25℃
refractive index 1.5101 (estimate)
Flash point 193°C
storage temp. Store below +30°C.
solubility 6g/l
pka pK1:4.358 (25°C)
form Crystalline Powder and Chunks
color White to light yellow
Water Solubility 6 g/L (20 ºC)
BRN 1101737
InChIKey NRPFNQUDKRYCNX-UHFFFAOYSA-N
LogP 1.295 at 25℃
CAS DataBase Reference 104-01-8(CAS DataBase Reference)
FDA UNII AJP2V8U5K6
NIST Chemistry Reference Benzeneacetic acid, 4-methoxy-(104-01-8)
EPA Substance Registry System Benzeneacetic acid, 4-methoxy- (104-01-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-20/21/22
Safety Statements  26-36
WGK Germany  3
RTECS  AI8960000
Hazard Note  Irritant
TSCA  Yes
HS Code  29189090
NFPA 704
1
2 0

4-Methoxyphenylacetic acid price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M19201 4-Methoxyphenylacetic acid ReagentPlus , 99% 104-01-8 5g $45.8 2024-03-01 Buy
Sigma-Aldrich M19201 4-Methoxyphenylacetic acid ReagentPlus , 99% 104-01-8 100g $71.9 2024-03-01 Buy
Sigma-Aldrich 8.21240 4-Methoxyphenylacetic acid for synthesis 104-01-8 100g $76.5 2022-05-15 Buy
TCI Chemical M0742 4-Methoxyphenylacetic Acid >98.0%(GC)(T) 104-01-8 25g $20 2024-03-01 Buy
TCI Chemical M0742 4-Methoxyphenylacetic Acid >98.0%(GC)(T) 104-01-8 100g $34 2024-03-01 Buy
Product number Packaging Price Buy
M19201 5g $45.8 Buy
M19201 100g $71.9 Buy
8.21240 100g $76.5 Buy
M0742 25g $20 Buy
M0742 100g $34 Buy

4-Methoxyphenylacetic acid Chemical Properties,Uses,Production

Uses

4-Methoxyphenylacetic Acid is a compound that was found from microbial phenolic metabolites in human feces after the consumption of gin, red wine and dealcholized red wine.

Description

4-METHOXYPHENYLACETIC ACID(104-01-8) is used in organic synthesis as well as pharmaceutical industry, especially used as an intermediate of puerarin. It can also be used as potential plasma biomarkers for early detection of non-small cell lung cancer. It is also used in drug industry as an intermediate to make Dextromethorphan.

Reference

Chen, Yan Ping, Y. M. Chen, and M. Tang. "Solubilities of cinnamic acid, phenoxyacetic acid and 4-methoxyphenylacetic acid in supercritical carbon dioxide." Fluid Phase Equilibria 275.1(2008):33-38.

Chemical Properties

white to light yellow crystalline powder and

Uses

4-Methoxyphenylacetic acid can be used:

  • To prepare methyl 4-methoxyphenylacetate by esterification with dimethyl carbonate using mesoporous sulfated zirconia catalyst.
  • As a ligand to synthesize pharmacologically important dinuclear gallium(III) and phenyltin(IV) carboxylate metal complexes.
  • As a reactant to synthesize hydroxylated (E)-stilbenes by reacting with substituted benzaldehydes via Perkin reaction.

Uses

4-Methoxyphenylacetic Acid is a compound that was found from microbial phenolic metabolites in human feces after the consumption of gin, red wine and dealcholized red wine.

Uses

Preparation of pharmaceuticals, other organic compounds.

Definition

ChEBI: A monocarboxylic acid that is phenylacetic acid carrying a 4-methoxy substituent. It is used as an intermediate for pharmaceuticals and other organic synthesis. It has been found to inhibit the germination of cress and lettuce seeds.

Synthesis Reference(s)

The Journal of Organic Chemistry, 51, p. 4354, 1986 DOI: 10.1021/jo00373a005
Tetrahedron Letters, 35, p. 133, 1994 DOI: 10.1016/0040-4039(94)88182-0

General Description

Pale yellow or off white colored flakes. Severely irritates skin and eyes. May be toxic by ingestion.

Reactivity Profile

Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in 4-Methoxyphenylacetic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Flammability and Explosibility

Not classified

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Crystallise the acid from EtOH/water, EtOAc/pet ether (m 87o) or *C6H6/pet ether (m 84-86o). [Beilstein 10 III 431, 10 IV 544.] The acid chloride [4693-91-8] has M 184.6, b 143o/10mm, d 254

104-47-2
104-01-8
Synthesis of 4-Methoxyphenylacetic acid from 4-Methoxybenzyl cyanide
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View Lastest Price from 4-Methoxyphenylacetic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Methoxyphenylacetic acid pictures 2023-09-12 4-Methoxyphenylacetic acid
104-01-8
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
4-Methoxyphenylacetic acid pictures 2023-07-19 4-Methoxyphenylacetic acid
104-01-8
US $30.00 / KG 1KG 99% 20 Tons Wuhan wingroup Pharmaceutical Co., Ltd
4-Methoxyphenylacetic acid pictures 2023-06-30 4-Methoxyphenylacetic acid
104-01-8
US $280.00-150.00 / kg 1kg 99% Purity (What/sapp: +86 18145728414) 1000 Tons/Month Guangzhou Tengyue Chemical Co., Ltd.
  • 4-Methoxyphenylacetic acid pictures
  • 4-Methoxyphenylacetic acid
    104-01-8
  • US $280.00-150.00 / kg
  • 99% Purity (What/sapp: +86 18145728414)
  • Guangzhou Tengyue Chemical Co., Ltd.
ASISCHEM D13364 LABOTEST-BB LT00848110 HOMOANISIC ACID HOMO-P-ANISIC ACID 4-METHOXYPHENYLACETIC ACID P-METHOXY-A-CARBOXYTOLUENE RARECHEM AL BO 0133 Acetic acid, (p-methoxyphenyl)- Benzeneaceticacid,4-methoxy- ethanoicacid,(4-methoxyphenyl)- p-Methioxy-toluicacid p-Methoxy-alpha-toluic acid p-methoxyphenyl-aceticaci p-Methoxy-α-carboxy-toluene p-Methoxy-α-toluic acid 4-Methoxyphenylacetic (4-methoxyphenyl)ethanoicacid 2-(p-Anisyl)acetic acid 2-(p-anisyl)aceticacid 4-Methoxybenzeneacetic acid 4-methoxy-benzeneaceticaci 4-methoxybenzeneaceticacid 4-methoxy-Benzeneaceticacid 4-methoxybenzeneethanoicacid 4-Methoxyphenylethanoicacid PARA-METHOXYPHENYLACETICACID ACETICACID,PARAMETHOXYPHENYL- 2-(p-Methoxyphenyl)acetic acid p-Anisylacetic acid 4-Methoxyphenylacetic acid ,99% 4-Methoxyphenylacetic acid, 98+% 4-Methoxyphenylaceti 4-Methoxyphenylacetic acid, 99% 5GR 4-Methoxyphenylacetic acid ReagentPlus(R), 99% 4-Methoxyphenylacetic Acid, 97+% The Methoxy benzene acetic acid 4-Methoxyphenylacetic acid Vetec(TM) reagent grade, 98% 4-Methoxyphenylacetic acid (4-MPAA) Homoanisic acid, 4-(Carboxymethyl)anisole 4-MethoxyphenylaceticAcid> 4-METHOXYPHENYLACETIC ACID FOR SYNTHESIS 4-methoxyphenylaceticaci Para Methoxy Phenyl Acetic acid (PMPA) TIANFU CHEM---4-Methoxyphenylacetic acid P-METHOXYPHENYLACETIC ACID Endogenous Metabolite,2 (4 Methoxyphenyl)acetic acid,inhibit,2(4Methoxyphenyl)acetic acid,Inhibitor 104-01-8 101-01-8 2004-01-8 CH3OC6H4CH2CO2H Building Blocks Organic Building Blocks C9 Carboxylic Acids Carbonyl Compounds Building Blocks C9 Carbonyl Compounds