licoricidin
- CAS No.
- 30508-27-1
- Chemical Name:
- licoricidin
- Synonyms
- licoricidin;Licorisoflavan B;LICORICIDIN (LCD);7-O-Demethyllicorisoflavan A;1,3-Benzenediol,4-[(3R)-3,4-dihydro-7-hydroxy-5-methoxy-6-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-3-yl]-2-(3-methyl-2-buten-1-yl)-
- CBNumber:
- CB51380788
- Molecular Formula:
- C26H32O5
- Molecular Weight:
- 424.53
- MDL Number:
- MFCD32182601
- MOL File:
- 30508-27-1.mol
- MSDS File:
- SDS
| Melting point | 161.0-162.5℃ |
|---|---|
| Boiling point | 610.8±55.0 °C(Predicted) |
| Density | 1.171±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 10.10±0.40(Predicted) |
| FDA UNII | 929XTD20VK |
licoricidin Chemical Properties,Uses,Production
Definition
ChEBI: Licoricidin is a member of the class of hydroxyisoflavans that is R-isoflavan with hydroxy groups at positions 7, 2' and 4', a methoxy group at position 5 and prenyl groups at positions 6 and 3'. Isolated from Glycyrrhiza uralensis, it exhibits antibacterial activity. It has a role as an antibacterial agent and a plant metabolite. It is a member of hydroxyisoflavans, an aromatic ether and a methoxyisoflavan.
Biological Activity
Licoricidin (LCD), isolated from Glycyrrhiza uralensis Fisch, has anticancer activity. It (LCD) can be used in the study of colorectal cancer by inducing cycle arrest, apoptosis and autophagy. Licoricidin (LCD) inhibits lung metastasis by inhibiting tumor angiogenesis and lymphangiogenesis and changes in the local microenvironment of tumor tissue. Licoricidin (LCD) enhances gemcitabine-induced cytotoxicity of osteosarcoma (OS) cells through inactivation of Akt and NF-κB pathways in vitro and in vivo.
in vitro
Licoricidin (LCD) (0-20 μM; 24 hours) dose-dependently inhibits the viability of colon cancer cell lines with various pathological and genetic characters, namely SW480, HCT116, SW620 and LoVo cells, with IC < sub> 50 values of 7.2, 5.4, 4.5 and 5.1 μM, respectively. Licoricidin (LCD) (0-20 μM; 0-12 hours) induces cell apoptosis was accompanied with the activation of caspase-3 by cleavage in a time- and dose-dependent manner. Licoricidin (LCD) (0-20 μM; 0-12 hours) induces autophagy of SW480 cells, increases the cleavage of LC3-I to LC3-II and the degradation of p62 in a time and Dose dependent manner. Licoricidin (LCD) (0-5 μg/ml; 18 hours) inhibits cell migration, MMP-9 secretion, and VCAM expression in 4T1 cells.
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Cell Viability Assay
| Cell Line: | SW480, HCT116, SW620 and LoVo cells | Concentration: | 0-20 μM |
| Incubation Time: | 24 hours |
| Result: | Decreased colon cancer cell lines viability. |
Western Blot Analysis < /p>
| Cell Line: | SW480 cells |
| Concentration: | 0 μM, 2.5 μM, 5 μM, 10 μM, 20 μM |
| Incubation Time: | 0 hours, 1 hour, 3 hours, 6 hours, 12 hours |
| Result: | Induced cell apoptosis. |
in vivo
Licoricidin (LCD) (intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 15 days) significantly inhibited the growth of SW480 xenografts in nude mice with an inhibitory rate of 43.5%. Licoricidin ( LCD) (intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 32 days) reduces pulmonary metastasis and the expression of CD45, CD31, HIF-1α, iNOS, COX-2, and VEGF-A in tumor tissues , additionally, decreased protein expression of VEGF-R2, VEGF-C, VEGF-R3, and LYVE-1 in tumor tissues of licoricidin-treated mice.
| Animal Model: | SW480 xenografted tumor growth in nude mice |
| Dosage: | 5, 10, or 20 mg/kg |
| Administration: | Intraperitoneal injection; once daily; 15 days |
| Result: | Decreased tumor volumes. |
| Animal Model: | BALB/c mouse orthotopic model |
| Dosage: | 5, 10, or 20 mg/kg |
| Administration: | Intraperitoneal injection; 5, 10, or 20 mg/kg; once daily; 32 days |
| Result: | Inhibited Lung Metastasis of 4T1 Murine Mammary Carcinoma cells. |
licoricidin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 13211707573; | y.liu@mail.biobiopha.com | China | 5654 | 65 |
| Shanghai Winherb Medical Technology Co., Ltd. | 400-186-5138 13341702378 | winherb@126.com | China | 1006 | 58 |
View Lastest Price from licoricidin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-09-08 | licoricidin
30508-27-1
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- licoricidin
30508-27-1
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.