SIRAMESINE
- CAS No.
- 147817-50-3
- Chemical Name:
- SIRAMESINE
- Synonyms
- CS-1476;SIRAMESINE;1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine];1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine];Spiro[isobenzofuran-1(3H),4'-piperidine], 1'-[4-[1-(4-fluorophenyl)-1H-indol-3-yl]butyl]-;1'-[4-[1-(4-Fluorophenyl)-1H-indol-3-yl]-1-butyl]spiro[isobenzofuran-1(3H),4'-piperidine];1'-(4-(1-(4-FLUOROPHENYL)-1H-INDOL-3-YL)BUTYL)-3H-SPIRO[ISOBENZOFURAN-1,4'-PIPERIDINE].HCL
- CBNumber:
- CB52446500
- Molecular Formula:
- C30H31FN2O
- Molecular Weight:
- 454.58
- MDL Number:
- MFCD00912182
- MOL File:
- 147817-50-3.mol
- MSDS File:
- SDS
| Boiling point | 611.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) |
| form | solid |
| pka | 9.45±0.20(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| FDA UNII | 3IX8CWR24V |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P305+P351+P338 |
SIRAMESINE price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | B1297 | Siramesine | 147817-50-3 | 5mg | $258 | 2021-12-16 | Buy |
| ApexBio Technology | B1297 | Siramesine | 147817-50-3 | 10mg | $391 | 2021-12-16 | Buy |
| ApexBio Technology | B1297 | Siramesine | 147817-50-3 | 25mg | $567 | 2021-12-16 | Buy |
| ApexBio Technology | B1297 | Siramesine | 147817-50-3 | 50mg | $927 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181320 | Siramesine >98% | 147817-50-3 | 100mg | $950.3 | 2021-12-16 | Buy |
SIRAMESINE Chemical Properties,Uses,Production
Description
Siramesine (Lu 28-179, 147817-50-3) is a σ2 selective agonist?(IC50’s: σ1 = 17nM, σ2 = 0.2nM).1?It produced non-sedating potent and long-last anxiolytic effects in rodents.2?Siramesine induced caspase-independent programmed cell death in various cancer cell lines?via?increased levels of ROS and lysosomal leakage.3,4,5?Mitochondrial destabilization via loss of membrane potential and increased ROS has also been offered as a mechanism of action for the triggering of cell death by Siramesine.6
Uses
Treatment of prostate cancer.
brand name
Provenge (Dendreon).
References
1) Perregaard?et al.?(1995),?Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles; J. Med. Chem.?38?1998 2) Sanchez?et al.?(1997),?The selective sigma2-ligand Lu 280179 has potent anxiolytic effects in rodents; J. Pharmacol. Exp. Ther.?283?1323 3) Ostenfeld?et al.?(2005),?Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress;?Cancer Res.?65?8975 4) Ostenfeld et al. (2008),?Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation; Autophagy?4?487 5) Dielschneider?et al.?(2016),?Lysosomotropic agents selectively target chronic lymphocytic leukemia cells due to altered sphingolipid metabolism; Leukemia?30?1290 6) Cesen?et al.?(2013),?Siramesine triggers cell death through destabilization of mitochondria, but not lysosomes; Cell Death Dis.?4?e818
SIRAMESINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 |
View Lastest Price from SIRAMESINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | SIRAMESINE
147817-50-3
|
US $5.50 / g | 1g | 98% | 1kg,10kg,100kg | Career Henan Chemical Co |
-
- SIRAMESINE
147817-50-3
- US $5.50 / g
- 98%
- Career Henan Chemical Co