SB 743921
- CAS No.
- 940929-33-9
- Chemical Name:
- SB 743921
- Synonyms
- CS-1972;SB 743921;SB-743921 HCl;SB 743921 USP/EP/BP;SB 743921 hydrochloride;SB743921;SB743921; SB 743921;SB-743921 hydrochloride hcl SB743921;(R)-N-(3-Aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylb;(R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylbenzamide hydrochloride;SB 743921; (R)-N-(3-AMINOPROPYL)-N-(1-(3-BENZYL-7-CHLORO-4-OXO-4H-CHROMEN-2-YL)-2-METHYLPROPYL)-4-METHYLBENZAMIDE HYDROCHLORIDE
- CBNumber:
- CB52517941
- Molecular Formula:
- C31H34Cl2N2O3
- Molecular Weight:
- 553.51926
- MDL Number:
- MFCD18385010
- MOL File:
- 940929-33-9.mol
| storage temp. | -20°C |
|---|---|
| solubility | H2O: soluble5mg/mL, clear |
| form | powder |
| color | white to beige |
| InChIKey | MLMZVWABFOLFGV-LNLSOMNWSA-N |
| FDA UNII | 2YW6FB68GM |
| NCI Drug Dictionary | SB-743921 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
SB 743921 price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1121 | SB743921 hydrochloride ≥98% (HPLC) | 940929-33-9 | 5mg | $254 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1121 | SB743921 hydrochloride ≥98% (HPLC) | 940929-33-9 | 25mg | $807 | 2024-03-01 | Buy |
| Cayman Chemical | 18384 | SB-743921 (hydrochloride) ≥98% | 940929-33-9 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 18384 | SB-743921 (hydrochloride) ≥98% | 940929-33-9 | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 18384 | SB-743921 (hydrochloride) ≥98% | 940929-33-9 | 10mg | $278 | 2024-03-01 | Buy |
SB 743921 Chemical Properties,Uses,Production
Uses
SB 743921 Hydrochloride is a mitotic kinesin inhibitor, which can be used to treat lung disease in combination with other therapy.
Biological Activity
sb743921 is an inhibitor of kinesin spindle protein (ksp) with ki value of 0.1nm [1].as an inhibitor of mitotic kinesin ksp, sb743921 causes cell cycle arrest in mitosis, results in cell death. sb743921 is developed to treat for cancers. sb743921 is a potent and selective inhibitor. in the affinity assays, sb743921 shows ki values of 0.1nm and 0.12nm for human ksp and mouse ksp, respectively. it has no affinity with other kinesins. in the cellular assay, sb743921 exerts anti-proliferation efficacy in skov3, colo205, mv522 and mx1 with ic50 values of 0.02nm, 0.07nm, 1.7nm and 0.06nm. moreover, sb743921 is shown to have activity against human tumor xenografts colo205, mcf-7, sk-mes, h69, ovcar-3, ht-29, mda-mb-231 and a2780. sb743921 is also effective against p388 lymphocytic leukemia xenografts in mice [1].
References
[1] jackson j r, gilmartin a, dhanak d, et al. a second generation ksp inhibitor, sb-743921, is a highly potent and active therapeutic in preclinical models of cancer. proceedings of the american association for cancer research, 2006, 2006(2): b11.
SB 743921 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29067 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hunan Jibang Biological Technology Co., LTD | +8613776644403 | sales02@kingboomtech.com | China | 1806 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
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