BI 882370
- CAS No.
- 1392429-79-6
- Chemical Name:
- BI 882370
- Synonyms
- CS-2615;BI 882370;BI882370;BI-882370;BI-882370,Raf,BI882370,inhibit,Inhibitor,Raf kinases,BI 882370;1-Propanesulfonamide, N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-;N-(3-(5-((1-Ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide
- CBNumber:
- CB53358255
- Molecular Formula:
- C28H33F2N7O2S
- Molecular Weight:
- 569.67
- MDL Number:
- MFCD31618072
- MOL File:
- 1392429-79-6.mol
| Boiling point | 649.6±65.0 °C(Predicted) |
|---|---|
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:5.0(Max Conc. mg/mL);8.78(Max Conc. mM) |
| form | A crystalline solid |
| pka | 5.48±0.10(Predicted) |
| FDA UNII | V32TR55QP9 |
BI 882370 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24273 | BI-882370 ≥95% | 1392429-79-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 24273 | BI-882370 ≥95% | 1392429-79-6 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 24273 | BI-882370 ≥95% | 1392429-79-6 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 24273 | BI-882370 ≥95% | 1392429-79-6 | 25mg | $533 | 2024-03-01 | Buy |
| ChemScene | CS-0030522 | BI-882370 99.16% | 1392429-79-6 | 50mg | $550 | 2021-12-16 | Buy |
BI 882370 Chemical Properties,Uses,Production
Description
BI-882370 is an orally bioavailable RAF inhibitor with IC50 values of 0.8, 0.8, and 0.6 nM for B-RAFV600E, wild-type B-RAF, and C-RAF in the DFG-out inactive conformation, respectively. It is selective for RAF over a panel of kinases, including LCK, KIT, Src, LYNA, LYNB, and PDGFR (IC50s = 49, 415, 485, 750, 715, and 1,220 nM, respectively). It inhibits proliferation of human B-RAF-mutant melanoma cells when used at concentrations ranging from 1 to 10 nM. It reduces tumor growth in multiple B-RAF-mutant melanoma and colorectal carcinoma mouse xenograft models when administered at a dose of 25 mg/kg twice per day. BI-882370, alone and in combination with trametinib , induces tumor regression in an A375 melanoma mouse xenograft model with no resistance developing within three or five weeks, respectively.
BI 882370 Preparation Products And Raw materials
Raw materials
Preparation Products
BI 882370 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4398 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8012 | 62 |