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BI 882370

化学構造式
1392429-79-6
CAS番号.
1392429-79-6
化学名:
别名:
英語名:
BI 882370
英語别名:
CS-2615;BI 882370;BI882370;BI-882370;BI-882370,Raf,BI882370,inhibit,Inhibitor,Raf kinases,BI 882370;1-Propanesulfonamide, N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-;N-(3-(5-((1-Ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide
CBNumber:
CB53358255
化学式:
C28H33F2N7O2S
分子量:
569.67
MOL File:
1392429-79-6.mol

BI 882370 物理性質

沸点 :
649.6±65.0 °C(Predicted)
比重(密度) :
1.37±0.1 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
DMSO:5.0(Max Conc. mg/mL);8.78(Max Conc. mM)
外見 :
A crystalline solid
酸解離定数(Pka):
5.48±0.10(Predicted)

安全性情報

BI 882370 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

BI 882370 化学特性,用途語,生産方法

説明

BI-882370 is an orally bioavailable RAF inhibitor with IC50 values of 0.8, 0.8, and 0.6 nM for B-RAFV600E, wild-type B-RAF, and C-RAF in the DFG-out inactive conformation, respectively. It is selective for RAF over a panel of kinases, including LCK, KIT, Src, LYNA, LYNB, and PDGFR (IC50s = 49, 415, 485, 750, 715, and 1,220 nM, respectively). It inhibits proliferation of human B-RAF-mutant melanoma cells when used at concentrations ranging from 1 to 10 nM. It reduces tumor growth in multiple B-RAF-mutant melanoma and colorectal carcinoma mouse xenograft models when administered at a dose of 25 mg/kg twice per day. BI-882370, alone and in combination with trametinib , induces tumor regression in an A375 melanoma mouse xenograft model with no resistance developing within three or five weeks, respectively.

BI 882370 上流と下流の製品情報

原材料

準備製品

BI 882370 生産企業

Global( 40)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
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Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
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InvivoChem 		+1-708-310-1919 +1-13798911105
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Aladdin Scientific 		+1-833-552-7181
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Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
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Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2923 55
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
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BOC Sciences 16314854226
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Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9709 58
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994
 2853530910@QQ.com China 8011 62

  スペクトルデータ(1HNMR)

BI 882370(1392429-79-6)1HNMR
  • 1392429-79-6
  • BI 882370
  • BI882370;BI-882370
  • 1-Propanesulfonamide, N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-
  • CS-2615
  • BI-882370,Raf,BI882370,inhibit,Inhibitor,Raf kinases,BI 882370
  • N-(3-(5-((1-Ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide
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