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SCRIPTAID

SCRIPTAID structure

CAS No.: 287383-59-9

Chemical Name:: SCRIPTAID

Synonyms: CS-1136;GCK 1026;Scriptide;Scriptaid (GCK1026);Scriptaid, Scriptide;GCK 1026; SCRIPTIDE; GCK1026; GCK-1026;6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide;1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-;6-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanaMide;Scriptide N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide

CBNumber:: CB5504770

Molecular Formula:: C18H18N2O4

Molecular Weight:: 326.35

MDL Number:: MFCD00386477

MOL File:: 287383-59-9.mol

MSDS File:: SDS

Last updated:2023-09-28 17:55:30

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SCRIPTAID Properties

Melting point	160-161 °C
Density	1.338±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up to 4 mg/ml).
pka	9.46±0.20(Predicted)
form	Yellow solid.
color	White
Sensitive	Light Sensitive
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
FDA UNII	EJQ8CD8BSV

SAFETY

Risk and Safety Statements

WGK Germany	3

SCRIPTAID price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S7817	Scriptaid ≥95%, solid	287383-59-9	1MG	$145	2023-06-20	Buy
Sigma-Aldrich	S7817	Scriptaid ≥95%, solid	287383-59-9	5MG	$493	2023-06-20	Buy
Sigma-Aldrich	565730	Scriptaid - CAS 287383-59-9 - Calbiochem A relatively non-toxic, cell-permeable hydroxamic acid-containing histone deacetylase (HDAC) inhibitor.	287383-59-9	5MG	$194	2022-05-15	Buy
Alfa Aesar	J67379	Scriptaid, 97%	287383-59-9	1mg	$101	2021-12-16	Buy
Cayman Chemical	10572	Scriptaid ≥98%	287383-59-9	1mg	$36	2024-03-01	Buy

Product number	Packaging	Price	Buy
S7817	1MG	$145	Buy
S7817	5MG	$493	Buy
565730	5MG	$194	Buy
J67379	1mg	$101	Buy
10572	1mg	$36	Buy

SCRIPTAID Chemical Properties,Uses,Production

Description

Scriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems. It induces cell cycle arrest in colon cancer cells in culture and inhibits tumor growth in vitro and in vivo. Scriptaid also facilitates the cloning of inbred mouse strains produced by somatic cell nuclear transfer.

Uses

Histone deacetylase inhibitor. A cell-permeable, relatively non-toxic HDAC inhibitor that facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient receptor assays in a concentration-dependent manner.

Uses

Scriptaid has been used in post activation of oocytes and embryo culture.

Definition

ChEBI: 6-(1,3-dioxo-2-benzo[de]isoquinolinyl)-N-hydroxyhexanamide is a member of isoquinolines.

General Description

Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.

Biological Activity

Novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.

Biochem/physiol Actions

Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.

References

1) Su?et al.?(2000),?A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library; Cancer Res.,?60?3137 2) Huber?et al.?(2011),?Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells; J. Biol. Chem.,?286?22211 3) Lee?et al.?(2008),?Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells; J. Oncol.,?33?767 4) Rissi?et al.?(2019),?Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos; Reproduction,?157?123 5) Huang?et al.?(2020),?Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin; J. Appl. Physiol.,?128?276

SCRIPTAID Preparation Products And Raw materials

Raw materials

Preparation Products

SCRIPTAID Suppliers

Global( 119)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12470	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hebei Duling International Trade Co. LTD	+8618712993135	sales01@hbduling.cn	China	15743	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Hubei xin bonus chemical co. LTD	58
career henan chemical co	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hebei Duling International Trade Co. LTD	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

View Lastest Price from SCRIPTAID manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-09-28	SCRIPTAID 287383-59-9	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
	2020-01-10	6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide 287383-59-9	US $0.01 / KG	1KG	98%; 99%	500g;1kg； 25kg	Career Henan Chemical Co

SCRIPTAID
287383-59-9
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide
287383-59-9
US $0.01 / KG
98%; 99%
Career Henan Chemical Co

SCRIPTAID Spectrum

SCRIPTAID(287383-59-9)¹HNMR

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GCK 1026 1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo- Scriptide 6-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanaMide Scriptaid, Scriptide Scriptide N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide Scriptaid (GCK1026) 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide GCK 1026; SCRIPTIDE; GCK1026; GCK-1026 CS-1136 287383-59-9 Inhibitor Amines Aromatics Inhibitors Intermediates & Fine Chemicals Pharmaceuticals