Neferine
- CAS No.
- 2292-16-2
- Chemical Name:
- Neferine
- Synonyms
- Neferin;NEFERINE;Methylliensinine;Neferine USP/EP/BP;4''-O-Methylliensinine;4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol;4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl)methyl]-2-[[1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methylisoquinolin-7-yl]oxy]phenol;4-(((S)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-(((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)phenol;4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol;4-[[(1r)-6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-1-yl]methyl]-2-[[(1r)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1h-isoquinolin-7-yl]oxy]phenol
- CBNumber:
- CB5706015
- Molecular Formula:
- C38H44N2O6
- Molecular Weight:
- 624.77
- MDL Number:
- MFCD01707128
- MOL File:
- 2292-16-2.mol
Melting point | 59-61 °C |
---|---|
Boiling point | 710.9±60.0 °C(Predicted) |
Density | 1.185±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: >15mg/mL |
form | powder |
pka | 9.28±0.45(Predicted) |
color | white to beige |
optical activity | [α]/D -34 to -44° (c=0 3. CHCl3) |
InChIKey | MIBATSHDJRIUJK-ROJLCIKYSA-N |
Neferine price More Price(29)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0349 | Neferine ≥98% (HPLC) | 2292-16-2 | 5mg | $113 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0349 | Neferine ≥98% (HPLC) | 2292-16-2 | 25mg | $441 | 2024-03-01 | Buy |
Usbiological | 300672 | Neferine | 2292-16-2 | 20mg | $490 | 2021-12-16 | Buy |
TRC | N389200 | Neferine | 2292-16-2 | 5mg | $220 | 2021-12-16 | Buy |
ChemScene | CS-5848 | Neferine 99.92% | 2292-16-2 | 25mg | $170 | 2021-12-16 | Buy |
Neferine Chemical Properties,Uses,Production
Description
A bisbenzylisoquinoline alkaloid from Nelumbo nucifera, the structure of this base has been shown to be that represented above based upon chemical degrada_x0002_tive studies and spectroscopic data. Four methoxyl groups, one hydroxyl and two methylimino groups are present.
Uses
Neferine is an isoquinoline alkaloid which enhances the antitumor effect of Mitomycin-C in hela cells through activation of p38-MAPK. Useful in the treatment of cervical cancers.
Definition
ChEBI: Neferine is a member of isoquinolines.
Biochem/physiol Actions
Neferine is a bis-benzylisoquinoline alkaloid isolated from the green seed embryos Nelumbo Nucifera Gaertn (Lotus) that displays multiple pharmacological activities including anti-tumor, antidepressant-like and antiarrhythmic actions. Recent studies shown that neferine potently inhibits proliferation of human osteosarcoma cells while is low-toxic on non-neoplastic human osteoblast cells. Apparently in U2OS cells, neferine stabilizes p21 through the activation of p38 MAPK, which leads to G1 cell cycle arrest. Also, neferine inhibits Ang II-induced HUVSMC proliferation by upregulation of HO-1.
References
Yang, Chen.,J. Chin. Chem. Soc., 17,235 (1970)
Neferine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
View Lastest Price from Neferine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-12 | Neferine
2292-16-2
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | ||
2023-02-24 | Neferine
2292-16-2
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | ||
2020-01-19 | Neferine
2292-16-2
|
US $3.00 / KG | 1KG | 98% | 1kg,5kg,50kg | Career Henan Chemical Co |