Urea

Urea Property

mp : 132-135 °C(lit.) density : 1.335 g/mL at 25 °C(lit.) refractive index : n20/D 1.40 storage temp. : 2-8°C solubility : H2O: 8 M at 20 °C form : powder color : white Water Solubility : 1080 g/L (20 ºC) Merck : 14,9867 BRN : 635724 Stability:: Substances to be avoided include strong oxidizing agents. Protect from moisture. CAS DataBase Reference: 57-13-6(CAS DataBase Reference) NIST Chemistry Reference: Urea(57-13-6) EPA Substance Registry System: Urea(57-13-6)

Safety

Hazard Codes : Xn,Xi Risk Statements : 36/37/38-40 Safety Statements : 26-36-24/25 WGK Germany : 1 RTECS : YR6250000 HS Code : 31021010 Hazardous Substances Data: 57-13-6(Hazardous Substances Data)

Urea Chemical Properties,Usage,Production

Chemical Properties White crystalline powder Usage Used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. Useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. May be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form. General Description Solid odorless white crystals or pellets. Density 1.335 g /cc. Noncombustible. Air & Water Reactions Water soluble. Reactivity Profile Urea is a weak base. Reacts with hypochlorites to form nitrogen trichloride which explodes spontaneously in air [J. Am. Chem. Soc. 63:3530-32]. Same is true for phosphorus pentachloride. Urea reacts with azo and diazo compounds to generate toxic gases. Reacts with strong reducing agents to form flammable gases (hydrogen). The heating of improper stoichiometric amounts of Urea and sodium nitrite lead to an explosion. Heated mixtures of oxalic acid and Urea yielded rapid evolution of gases, carbon dioxide, carbon monoxide and ammonia (if hot, can be explosive). Titanium tetrachloride and Urea slowly formed a complex during 6 weeks at 80°C., decomposed violently at 90°C., [Chem. Abs., 1966, 64, 9219b]. Urea ignites spontaneously on stirring with nitrosyl perchlorate, (due to the formation of the diazonium perchlorate). Oxalic acid and Urea react at high temperatures to form toxic and flammable ammonia and carbon monoxide gasses, and inert CO2 gas [Von Bentzinger, R. et al., Praxis Naturwiss. Chem., 1987, 36(8), 41-42]. Health Hazard May irritate eyes. Fire Hazard Behavior in Fire: Melts and decomposes, generating ammonia.

Urea Preparation Products And Raw materials

Raw materials Liquefied petroleum ges HEAVY CUT RESIDUE OIL Glycine CARBON DIOXIDE 2,2'-Iminodiethanol METALLURGICAL COKE PETROLEUM ETHER Vanadium pentoxide Acetic acid glacial AMMONIUM CARBAMATE Ammonia

Preparation Products Reactive Black KN-BN ureaformaldelyde resin UF 5-CARBETHOXYURACIL 2,4-DICHLOROTHIENO[3,2-D]PYRIMIDINE DIHYDROTHYMINE Furacilin Tanning agent for white leather synthetic carbamider ring tanning agent No.1 1-(2-Aminoethyl)imidazolidin-2-one DIRECT FAST BLACK G Carbachol 5,6-DIHYDROURACIL Pigment Yellow 65 6-Aminouracil flame retardane ZR-01 Thieno[3,2-d]pyrimidine, 2,4-dichloro- 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine biodegrddable finishing agent for fabric BIUREA 1-(1,3-DIHYDRO-1-OXOISOBENZOFURAN-3-YL)UREA N,N''-(isobutylidene)diurea 1-Methyl-1-nitrosourea 4,5-dihydroxy-1,3-bis(hydroxymethyl)imidazolidin-2-one 3-Hydroxy-1-phenyl-1,2,4-triazole DICHLOROISOCYANURIC ACID Cymoxanil 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Urea hydrogen peroxide 5-(sec-pentyl)barbituric acid Amino moulding plastic Tableware cleaner synthetic tanning agent PNC rubber latex 104T/C Biuret ETHYL 2-HYDROXYPYRIMIDINE-5-CARBOXYLATE 1-PHENYLSEMICARBAZIDE ALLYLUREA Water flush fertilizer 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLIC ACID 2,4-DIHYDROXYTHIENO[3,2-D]PYRIMIDINE

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