Tributyrin
- CAS No.
- 60-01-5
- Chemical Name:
- Tributyrin
- Synonyms
- GLYCEROL TRIBUTYRATE;GLYCERYL TRIBUTYRATE;C4:0;FEMA 2223;Glycerol tributanoate;BUTYRIN;C15H26O6;TRI-N-BUTYRIN;Butanoic acid, 1,2,3-propanetriyl ester;Kodaflex
- CBNumber:
- CB5853942
- Molecular Formula:
- C15H26O6
- Molecular Weight:
- 302.36
- MDL Number:
- MFCD00009392
- MOL File:
- 60-01-5.mol
- MSDS File:
- SDS
| Melting point | -75 °C |
|---|---|
| Boiling point | 305 °C |
| Density | 1.0335 |
| FEMA | 2223 | (TRI-)BUTYRIN |
| refractive index |
n |
| Flash point | 345 °F |
| storage temp. | Store at RT. |
| solubility | H2O: insoluble |
| form | Liquid |
| color | Clear colorless to yellow |
| Odor | at 100.00 %. cheese waxy creamy fatty |
| Odor Type | cheesy |
| Water Solubility | Not miscible in water. |
| Merck | 14,9620 |
| JECFA Number | 922 |
| BRN | 1714746 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | UYXTWWCETRIEDR-UHFFFAOYSA-N |
| LogP | 2.95 |
| FDA 21 CFR | 184.1903 |
| Substances Added to Food (formerly EAFUS) | GLYCEROL TRIBUTYRATE |
| CAS DataBase Reference | 60-01-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | tributyrin |
| FDA UNII | S05LZ624MF |
| NCI Drug Dictionary | tributyrin |
| EPA Substance Registry System | Tributyrin (60-01-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331 | |||||||||
| Precautionary statements | P501-P261-P270-P271-P264-P280-P361+P364-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | ET7350000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29171900 | |||||||||
| NFPA 704 |
|
Tributyrin price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 91010 | Glyceryl tributyrate puriss., ≥98.5% (GC) | 60-01-5 | 25ml | $86.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 73105 | Glyceryl tributyrate analytical standard | 60-01-5 | 1ml | $82.8 | 2024-03-01 | Buy |
| TCI Chemical | T0364 | Tributyrin >98.0%(GC) | 60-01-5 | 25mL | $30 | 2024-03-01 | Buy |
| TCI Chemical | T0364 | Tributyrin >98.0%(GC) | 60-01-5 | 500mL | $216 | 2024-03-01 | Buy |
| Alfa Aesar | A11830 | Glycerol tributyrate, 98% | 60-01-5 | 50g | $31.6 | 2024-03-01 | Buy |
Tributyrin Chemical Properties,Uses,Production
Description
Tributyrin (C15H26O6), also known as butyrin or glyceryl tributyrate, is the triester of glycerin and butyric acid. It is prepared by esterifcation of glycerin with excess butyric acid. Glycerol tributyrate has a characteristic odor and a bitter taste.
Tributyrin is essentially a triacylglyceride (TAG), which is an ester derived from glycerol and 3 fatty acids. Tributyrin requires lipase to release the butyrate attached to the glycerol. Although 1 tributyrin contains 3 butyrate, not all 3 butyrate is guaranteed to be released. This is because lipase is regioselective. It can hydrolyse triacylglycerides at R1 and R3, only R2, or non-specifically. Lipase also has substrate specificity in that the enzyme can differentiate between acyl chains attached to the glycerol and preferentially cleaving certain types. Since tributyrin requires lipase to release its butyrate, there may be competition between tributyrin and other TAGs for lipase.
Chemical Properties
Tributyrin is a colorless, oily liquid with a bitter taste. It is soluble in alcohol and ether and fairly insoluble in water.
Chemical Properties
Glycerol tributyrate has a characteristic odor and bitter taste.
Uses
Tributyrin is a stable and rapidly absorbed prodrug of butyric acid which enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells.
Uses
Tributyrin is a flavoring agent that is the triester of glycerin and butyric acid. it is prepared by esterification of glycerin with excess butyric acid. it is used in the following foods: baked goods; alcoholic beverages; nonalcoholic beverages; fats and oils; frozen dairy des- serts and mixes; gelatins, puddings and fillings; and soft candy. it is also termed butyrin and glyceryl tributyrate.
Production Methods
Tributyrin is manufactured via esterification of glycerol with butyric acid.
Definition
ChEBI: A triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by butyric acid.
Preparation
Prepared by esterifcation of glycerol with excess butyric acid.
Taste threshold values
Taste characteristics at 30 ppm: bitter, waxy, fatty, cheese and butter nuances.
General Description
Tributyrin is a short-chain triacylglycerol that mainly occurs in butter. It shows potent anti-cancer property.
Biochem/physiol Actions
Taste at 30 ppm
Safety Profile
Poison by intravenous route. Low toxicity by ingestion. Questionable carcinogen with experimental tumorigenic data. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS
Carcinogenicity
Administration of sodium butyrate in drinking water potentiates 1,2-dimethylhydrazine- induced colon cancer in rats . In mice, dietary administration of 5% tributyrin for 48 weeks did not lead to an increase in colonic tumor incidence or focal areas of dysplasia as compared to controls . Therefore, it has been suggested that the agent responsible for enhanced tumorigenesis in the rat study was sodium, rather than butyrate.
Tributyrin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Anhui Yiao New Material Technology Co., Ltd | +86-199-55145978 +8619955145978 | sales8@anhuiyiao.com | China | 253 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@airuikechemical.com | China | 994 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
View Lastest Price from Tributyrin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | Tributyrin
60-01-5
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2024-04-07 | Tributyrin
60-01-5
|
US $0.00-0.00 / Kg | 1Kg | 99.9% | 200tons | airuikechemical co., ltd. | |
 |
2023-09-05 | Tributyrin
60-01-5
|
US $40.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- Tributyrin
60-01-5
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- Tributyrin
60-01-5
- US $0.00-0.00 / Kg
- 99.9%
- airuikechemical co., ltd.
-
- Tributyrin
60-01-5
- US $40.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.