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NF 279

NF 279 Structure
NF 279 structure
CAS No.
202983-32-2
Chemical Name:
NF 279
Synonyms
NF 279;CS-319;NF279 - CAS 202983-32-2 - Calbiochem;8,8[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhex;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid;8,8'-(CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO))BIS-1,3,5-NAPHTHALENETRISULFONIC ACID, NA;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid sodium salt;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhexasodiumsalt;8,8'-[CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO)]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID HEXASODIUM SALT;8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid hexasodium salt
CBNumber:
CB6135641
Molecular Formula:
C49H37N6NaO23S6
Molecular Weight:
1293.2
MDL Number:
MFCD01861187
MOL File:
202983-32-2.mol
Last updated:2023-06-30 15:45:59
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NF 279 Properties

storage temp. Desiccate at -20°C
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form White solid
Water Solubility Soluble to 25 mM in water
Stability Hygroscopic

NF 279 price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 480418 NF279 - CAS 202983-32-2 - Calbiochem
A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC /KB ~ 1 μM in smooth muscle). 		202983-32-2 5mg $251 2024-03-01 Buy
Tocris 1199 NF279 ≥95%(HPLC) 202983-32-2 50 $887 2021-12-16 Buy
Tocris 1199 NF279 ≥95%(HPLC) 202983-32-2 10 $212 2021-12-16 Buy
TRC N391680 NF279 202983-32-2 250mg $2065 2021-12-16 Buy
Usbiological 255973 NF 279 202983-32-2 10mg $466 2021-12-16 Buy
Product number Packaging Price Buy
480418 5mg $251 Buy
1199 50 $887 Buy
1199 10 $212 Buy
N391680 250mg $2065 Buy
255973 10mg $466 Buy

NF 279 Chemical Properties,Uses,Production

Uses

NF 279 is a potent and selective P2X1 antagonist.

General Description

A suramin analog that acts as a highly selective, competitive, and reversible ATP-antagonist of P2X receptor (IC50/KB ~1 μM in smooth muscle). Effectively discriminates between P2Y and P2X receptors with no discernible effects on α1A adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and neuronal nicotinic acetylcholine receptors. Displays a selectivity profile of P2X1 >P2X2 >P2X3 >P2X4 (IC50 = 19 nM, 770 nM, 1.62 μM and >300 μM, respectively) in Xenopus oocytes pre-incubated with ATP. In rat and human tissues, exhibits a potency profile of rat P2X1 > human P2X1 ? rat P2X2 > rat P2X3 ~human P2X7 ? human P2X4. Not degraded by ecto-nucleotidases.

Biological Activity

A potent and selective P2X 1 antagonist (IC 50 = 19 nM). Displays good selectivity over P2X 2 ,(IC 50 = 0.76 μ M), P2X 3 (IC 50 = 1.62 μ M), P2X 4 (IC 50 > 300 μ M), P2Y receptors and ecto-nucleotidases.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at -20°C

NF 279 Preparation Products And Raw materials

Raw materials

Preparation Products

NF 279 Suppliers

Global( 49)Suppliers
Supplier Tel Email Country ProdList Advantage
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2784 58
Jinan Mingya Medical Technology Co., Ltd. 0531-85828981 864598798@qq.com China 588 58
AdooQ Bioscience CHINA 025-58849295 18951903616; info@adooq.cn China 2989 60
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
BOC Sciences -- info@bocsci.com USA 0 65
Changzhou Chenhong Biotechnology Co., Ltd. 0519-85788828 13775037613 sales@chemrenpharm.com China 3538 58
Cckinase, Inc. +1 (732)236-3202 sales@cckinase.com United States 2738 58
Supplier Advantage
Career Henan Chemica Co 		58
LEAPCHEM CO., LTD. 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
AdooQ BioScience, LLC 58
Jinan Mingya Medical Technology Co., Ltd. 58
AdooQ Bioscience CHINA 60
Sigma-Aldrich 80
BOC Sciences 65
Changzhou Chenhong Biotechnology Co., Ltd. 58
Cckinase, Inc. 58

202983-32-2(NF 279)Related Search:

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1of3

NF 279 8,8'-(CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO))BIS-1,3,5-NAPHTHALENETRISULFONIC ACID, NA 8,8'-[CARBONYLBIS(IMINO-4,1-PHENYLENECARBONYLIMINO-4,1-PHENYLENECARBONYLIMINO)]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID HEXASODIUM SALT 8,8[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhex 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid hexasodium salt 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid sodium salt 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhexasodiumsalt NF279 - CAS 202983-32-2 - Calbiochem CS-319 202983-32-2 C49H30N4Na6O21S6 C49H30N6O23S66Na C49H30N6Na6O23S6 Purinergics P2 receptor