PAFURAMIDINE
- CAS No.
- 186953-56-0
- Chemical Name:
- PAFURAMIDINE
- Synonyms
- DB289;PAFURAMIDINE;Unii-H1vg379J2x;4,4'-(2,5-Furandiyl)bis[N-methoxybenzenecarboximidamide];BenzenecarboxiMidaMide,4,4'-(2,5-furandiyl)bis[N-Methoxy-
- CBNumber:
- CB61509126
- Molecular Formula:
- C20H20N4O3
- Molecular Weight:
- 364.4
- MDL Number:
- MFCD09954138
- MOL File:
- 186953-56-0.mol
- MSDS File:
- SDS
Melting point | 192.5-193 ºC |
---|---|
Boiling point | 457.7±55.0 °C(Predicted) |
Density | 1.25 |
storage temp. | -20°C Freezer, Under inert atmosphere |
solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
pka | 6.01±0.50(Predicted) |
form | Solid |
color | Pale Yellow to Light Yellow |
FDA UNII | H1VG379J2X |
PAFURAMIDINE price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | P133875 | Pafuramidine | 186953-56-0 | 100mg | $1375 | 2021-12-16 | Buy |
ChemScene | CS-1470 | Pafuramidine 98.01% | 186953-56-0 | 100mg | $1680 | 2021-12-16 | Buy |
ApexBio Technology | A3695 | Pafuramidine | 186953-56-0 | 100mg | $2051 | 2021-12-16 | Buy |
ChemScene | CS-1470 | Pafuramidine 98.01% | 186953-56-0 | 50mg | $1080 | 2021-12-16 | Buy |
ApexBio Technology | A3695 | Pafuramidine | 186953-56-0 | 50mg | $1319 | 2021-12-16 | Buy |
PAFURAMIDINE Chemical Properties,Uses,Production
Uses
Treatment of malaria, African sleeping sickness, and pneumocystis pneumonia.
Uses
Pafuramidine is a prodrug of Furamidine (F863600, 2HCl); a diphenylfuran compound belonging to an important class of antimicrobial and antiparasitic agents. Furamidine and its analogues also display antitumor activities and showed antiproliferative activities against various tumor cell lines.
Biological Activity
pafuramidine, an orally bioavailable prodrug of furamidine (db75) with considerable trypanocidal activity, is an experimental drug for the treatment of pneumocystis pneumonia (pcp). pafuramidine is well tolerated and has clinical activity against pneumocystis pneumonia[1].
in vivo
inmurine models of human african trypanosomiasis, clearance of parasites from the peripheral circulation started 48 h after initiation of treatment with pafuramidineand was complete in all groups 6 days after the first drug dose. administration of pafuramidine po or ip at dose rates equal to or greater than 4 mg/kg resulted in 100% cure rates [2]. in the vervet monkey (chlorocebus [cercopithecus] aethiops) model of sleeping sickness, pafuramidine (10 mg/kg) completely cured all three monkeys, whereas lower doses of 3 mg/kg and 1 mg/kg cured only one of three and zero of three monkeysin an early-stage infection, respectively. in a late-stage infection, pafuramidine treatment resulted in cure rates of one of three and zero of three monkeys. these data indicated the limited ability of pafuramidine to cross the blood-brain barrier [3].
References
[1] chen d, marsh r, aberg j a. pafuramidine for pneumocystis jiroveci pneumonia in hiv-infected individuals[j]. expert review of anti-infective therapy, 2007, 5(6): 921-928.
[2] thuita j k, karanja s m, wenzler t, et al. efficacy of the diamidine db75 and its prodrug db289, against murine models of human african trypanosomiasis[j]. actatropica, 2008, 108(1): 6-10.
[3] mdachi r e, thuita j k, kagira j m, et al. efficacy of the novel diamidine compound 2, 5-bis (4-amidinophenyl)-furan-bis-o-methlylamidoxime (pafuramidine, db289) against trypanosoma bruceirhodesiense infection in vervet monkeys after oral administration[j]. antimicrobial agents and chemotherapy, 2009, 53(3): 953-957.
[4] harrilla h, desmet k d, wolf k k, et al. a mouse diversity panel approach reveals the potential for clinical kidney injury due to db289 not predicted by classical rodent models[j]. toxicological sciences, 2012: kfs238.
PAFURAMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
PAFURAMIDINE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
Shanghai Fuhe Chemistry Technology Co., Ltd. | 0086-21-67651709 | cfx759@hotmail.com | China | 410 | 57 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 17994 | 56 |
View Lastest Price from PAFURAMIDINE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-12-26 | PAFURAMIDINE
186953-56-0
|
US $1.00 / g | 1g | ≥98% | g/kg/Ton | Career Henan Chemical Co |
- PAFURAMIDINE
186953-56-0
- US $1.00 / g
- ≥98%
- Career Henan Chemical Co