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5-Chloro-1-methyl-4-nitroimidazole

5-Chloro-1-methyl-4-nitroimidazole Structure
5-Chloro-1-methyl-4-nitroimidazole structure
CAS No.
4897-25-0
Chemical Name:
5-Chloro-1-methyl-4-nitroimidazole
Synonyms
5-CHLORO-1-METHYL-4-NITRO-1H-IMIDAZOLE;CMNI;pcmni;NSC-7852;S-50154-9;A(S50154-9);AZATHIOPRINUM;TIMTEC-BB SBB003949;Azathioprine Impurity 9;Azathioprine EP Impurity C
CBNumber:
CB6151649
Molecular Formula:
C4H4ClN3O2
Molecular Weight:
161.55
MDL Number:
MFCD00233664
MOL File:
4897-25-0.mol
MSDS File:
SDS
Last updated:2024-04-08 17:36:13
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5-Chloro-1-methyl-4-nitroimidazole Properties

Melting point 148-150 °C (lit.)
Boiling point 362.3±22.0 °C(Predicted)
Density 1.9518 (rough estimate)
refractive index 1.5500 (estimate)
storage temp. Inert atmosphere,2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka -1.37±0.61(Predicted)
form Powder
color White
InChIKey OSJUNMSWBBOTQU-UHFFFAOYSA-N
CAS DataBase Reference 4897-25-0(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII P917JW98BD
NIST Chemistry Reference 1H-imidazole, 5-chloro-1-methyl-4-nitro-(4897-25-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338-P280a-P304+P340-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  NI4397100
HazardClass  IRRITANT
HS Code  29332900
NFPA 704
1
2 0

5-Chloro-1-methyl-4-nitroimidazole price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 367532 5-Chloro-1-methyl-4-nitroimidazole 98% 4897-25-0 5g $138 2024-03-01 Buy
TCI Chemical C1646 5-Chloro-1-methyl-4-nitroimidazole >98.0%(N) 4897-25-0 5g $84 2024-03-01 Buy
Alfa Aesar H61824 5-Chloro-1-methyl-4-nitroimidazole, 95% 4897-25-0 1g $33.9 2023-06-20 Buy
Alfa Aesar H61824 5-Chloro-1-methyl-4-nitroimidazole, 95% 4897-25-0 5g $115 2023-06-20 Buy
TRC C369270 5-Chloro-1-methyl-4-nitroimidazole 4897-25-0 5g $120 2021-12-16 Buy
Product number Packaging Price Buy
367532 5g $138 Buy
C1646 5g $84 Buy
H61824 1g $33.9 Buy
H61824 5g $115 Buy
C369270 5g $120 Buy

5-Chloro-1-methyl-4-nitroimidazole Chemical Properties,Uses,Production

Description

5-Chloro-1-methyl-4-nitroimidazole is an imidazole derivative. It is useful in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells. It can also be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine) palladium (II), K2CO3 and tetrabutylammonium bromide. 

References

http://www.sigmaaldrich.com/catalog/product/aldrich/367532?lang=en&region=US
Watts, M. E., et al. "Rapid-mix studies on the anomalous radiosensitization of mammalian cells by 5-chloro-1-methyl-4-nitromidazole." Int J Radiat Biol Relat Stud Phys Chem Med 38.6(1980):673-675.
Saadeh, H. A, I. M. Mosleh, and M. M. Elabadelah. "New synthesis and antiparasitic activity of model 5-aryl-1-methyl-4-nitroimidazoles. "Molecules 14.8(2009):2758-67.

Description

5-Chloro-1-methyl-4-nitroimidazole is an intermediate in azathioprine synthesis, also present in the end product. It induced contact dermatitis in a man working on azathioprine synthesis. Cross reactivity is possible with imidazoles tioconazole, and econazole.

Chemical Properties

White Solid

Uses

5-Chloro-1-methyl-4-nitroimidazole (CMNI) is suitable for use in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells by CMNI. It may be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine)palladium(II), K2CO3 and tetrabutylammonium bromide.

General Description

5-Chloro-1-methyl-4-nitroimidazole is an 4-nitroimidazole derivative.

Contact allergens

This intermediate in azathioprine synthesis is also present in the end product. It induced contact dermatitis in a man working on azathioprine synthesis. Cross-reactivity is possible with imidazoles tioconazole and econazole.

5-Chloro-1-methyl-4-nitroimidazole Preparation Products And Raw materials

Raw materials

Glass-lined reaction pot Phosphorus oxychloride Phosphorus pentachloride N,N'-Dimethyloxalamide 5-Chloro-1-methylimidazole
Potassium nitrate

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Preparation Products

Azathioprine 1H-Imidazol-5-amine,1-methyl-4-nitro-(9CI)

5-Chloro-1-methyl-4-nitroimidazole Suppliers

Global( 283)Suppliers
Supplier Tel Email Country ProdList Advantage
airuikechemical co., ltd. 		+undefined86-15315557071 sales02@airuikechemical.com China 994 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
NINGBO INNO PHARMCHEM CO., LTD. 		13867897135 sales@nbinno.com CHINA 925 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10248 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Accela ChemBio Inc. 		(+1)-858-699-3322 info@accelachem.com United States 19965 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Supplier Advantage
airuikechemical co., ltd. 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
career henan chemical co 		58
NINGBO INNO PHARMCHEM CO., LTD. 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Accela ChemBio Inc. 		58
Hubei xin bonus chemical co. LTD 		58
Standardpharm Co. Ltd. 		58
Chongqing Chemdad Co., Ltd 		58

View Lastest Price from 5-Chloro-1-methyl-4-nitroimidazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-Chloro-1-methyl-4-nitroimidazole pictures 2024-04-08 5-Chloro-1-methyl-4-nitroimidazole
4897-25-0
 US $0.00-0.00 / Kg 1Kg 99.9% 200tons airuikechemical co., ltd.
5-Chloro-1-methyl-4-nitroimidazole pictures 2022-09-30 5-Chloro-1-methyl-4-nitroimidazole
4897-25-0
 US $0.00-0.00 / KG 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
5-Chloro-1-methyl-4-nitroimidazole pictures 2019-12-23 5-Chloro-1-methyl-4-nitroimidazole
4897-25-0
 US $0.00 / g 1g 95%min 20kg/month Nanjing jinheyou Trading Co., Ltd.

5-Chloro-1-methyl-4-nitroimidazole Spectrum

5-Chloro-1-methyl-4-nitroimidazole(4897-25-0)MS5-Chloro-1-methyl-4-nitroimidazole(4897-25-0)IR15-Chloro-1-methyl-4-nitroimidazole(4897-25-0)IR2

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5-chloro-1-methyl-4-nitroimidazole Solution, 100ppm 5-Chloro-1-methyl-4-nitroimidazole≥ 99% (HPLC) 5-chloro-1-methyl-4-nitro-imidazol A(S50154-9) Imidazole, 5-chloro-1-methyl-4-nitro- pcmni TIMTEC-BB SBB003949 1-METHYL-5-CHLORO-4-NITRO IMIDAZOLE 1-METHYL-4-NITRO-5-CHLORO IMIDAZOLE AZATHIOPRINUM 5-CHLORO-1-METHYL-4-NITROIMIDAZOLE 5-Chloro-1-Methyl-4-NitroImidazole(ForAzathiopurine) 5-CHLORO-1-METHYL-4-NITROIMIDAZOLE (AZATHIOPRINUM) 1-Methyl-4-Nitro-5-Chloroimida 1H-Imidazole, 5-chloro-1-methyl-4-nitro- S-50154-9 1-Methyl-5-chloro-4-nitro-1H-imidazole CMNI NSC-7852 5-Chloro-1-methyl-4-nitroimidazole,98% Azathioprine EP Impurity C Azathioprine Impurity Ⅰ: 5-Chloro-1-methyl-4-nitroimidazole Azathioprine Impurity 3（Azathioprine EP Impurity C） 5-Chloro-1-methyl-4-nitroimidazole > Azathioprine Impurity 9 Azathioprine BP Impurity C 5-Chloro-1-methyl-4-nitroimidazole Solution in Methanol, 100μg/mL Azathioprine Impurity Ⅰ: 5-Chloro-1-methyl-4-nitroimidazole 5-CHLORO-1-METHYL-4-NITRO-1H-IMIDAZOLE 5-Chloro-1-methyl-4-nitroimidazole (Azathioprine Impurity) 4897-25-0 C4H4ClN3O2 Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Imidazoles Heterocycles Halogenated Heterocycles Heterocyclic Building Blocks Imidazoles ImidazolesBuilding Blocks Building Blocks Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks Heterocyclic Compounds Imidaxoles