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1-benzyl-4-methylpiperidin-3-one

1-benzyl-4-methylpiperidin-3-one Structure
1-benzyl-4-methylpiperidin-3-one structure
CAS No.
32018-96-5
Chemical Name:
1-benzyl-4-methylpiperidin-3-one
Synonyms
Tofacitinib Impurity 192;Moxifloxacin Impurity 158;Tofacitinib Impurity 16 HCl;Tofacitinib Impurity 13 HCl;1-benzyl-4-methylpiperidin-3-on;Tofacitinib Impurity 192 Monomer;1-benzyl-4-methylpiperidin-3-one;4-Methyl-1-(phenylmethyl)-3-piperidinone;3-Piperidinone, 4-Methyl-1-(phenylMethyl)-;Methyl-1-(phenylMethyl) 3-piperidone hydrochloride
CBNumber:
CB62485153
Molecular Formula:
C13H17NO
Molecular Weight:
203.28
MDL Number:
MFCD16619159
MOL File:
32018-96-5.mol
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1-benzyl-4-methylpiperidin-3-one Properties

Boiling point 302.9±35.0 °C(Predicted)
Density 1.057
storage temp. Sealed in dry,Store in freezer, under -20°C
pka 6.13±0.40(Predicted)

1-benzyl-4-methylpiperidin-3-one price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC B287190 1-Benzyl-4-methylpiperidin-3-one 32018-96-5 25g $565 2021-12-16 Buy
AK Scientific 3525AB 1-Benzyl-4-methylpiperidin-3-one 32018-96-5 5g $117 2021-12-16 Buy
Matrix Scientific 112788 4-Methyl-1-(phenylmethyl)-3-piperidinone 32018-96-5 5g $781 2021-12-16 Buy
American Custom Chemicals Corporation CHM0093002 1-BENZYL-4-METHYLPIPERIDIN-3-ONE 95.00% 32018-96-5 1G $983.52 2021-12-16 Buy
American Custom Chemicals Corporation CHM0093002 1-BENZYL-4-METHYLPIPERIDIN-3-ONE 95.00% 32018-96-5 2.5G $1473.14 2021-12-16 Buy
Product number Packaging Price Buy
B287190 25g $565 Buy
3525AB 5g $117 Buy
112788 5g $781 Buy
CHM0093002 1G $983.52 Buy
CHM0093002 2.5G $1473.14 Buy

1-benzyl-4-methylpiperidin-3-one Chemical Properties,Uses,Production

Synthesis

A 640-L vessel was charged with SO3.pyridine (51.47 kg, 323.1 mol). DMSO (169 L) was added and the whole was heated slowly to 33 °C. After a solution was obtained, it was cooled to 25 °C. The TsOH salt of the amine (40.9 kg, 107.7 mol) was added into the vessel and suspended in DMSO (50 L). After the addition of Et3N (62 L, 43.8 mol), the SO3.pyridine solution in DMSO was added to the two-phase mixture in the vessel at such a rate as to keep the internal temperature below 25 °C. After 1 h of stirring at 22 °C, the reaction was 92% complete. The mixture was cooled to 10 °C and quenched with water (182 L) over a period of 40 min at such a rate as to keep the internal temperature below 17 °C; a 25% NH3 solution (16 L) was then added. After phase separation, the aqueous phase was extracted with three portions of toluene (3 × 60 L) while controlling the pH of the aqueous layer to 10 after each extraction. The combined organic phases (approximately 240 L) were extracted with water  (61 L), and the bright-orange solution was heated at 40−50 °C jacket temperature over 1 h while blowing a nitrogen stream into the solution via an immersing tube. Then, toluene (170 L) was stripped off at 50 °C to afford the ketone (50.84 kg, 93%) as an orange solution in toluene.
synthesis of 1-benzyl-4-methylpiperidin-3-one

Uses

1-Benzyl-4-methylpiperidin-3-one is an intermediate used to prepare pyrrolo[2,3-d]pyrimidine compds. as inhibitors of protein kinases.

1-benzyl-4-methylpiperidin-3-one Preparation Products And Raw materials

Raw materials

Preparation Products

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

1-benzyl-4-methylpiperidin-3-one Suppliers

Global( 107)Suppliers
Supplier Tel Email Country ProdList Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10248 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
Shanghai Yingrui Biopharma Co.,Ltd 		21-33585366 export01@shyrchem.com CHINA 1320 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21149 58
Supplier Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Chongqing Chemdad Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
Shanghai Yingrui Biopharma Co.,Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58

View Lastest Price from 1-benzyl-4-methylpiperidin-3-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-benzyl-4-methylpiperidin-3-one pictures 2022-09-12 1-benzyl-4-methylpiperidin-3-one
32018-96-5
 US $0.00-0.00 / KG 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
1-benzyl-4-methylpiperidin-3-one pictures 2019-07-06 1-benzyl-4-methylpiperidin-3-one
32018-96-5
 US $100.00 / KG 1KG 98% 100KG Career Henan Chemical Co

32018-96-5(1-benzyl-4-methylpiperidin-3-one)Related Search:

3-(BOC-AMINO)-4-PICOLINE 3-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino) piperidin-1-yl)-3-oxopropanenitrile citric acid tert-butyl methyl((3R,4R)-4-methyl-1-tosylpiperidin-3-yl)carbamate N-((3SR,4RS)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3RS,4SR)-methyl 1-benzyl-4-methylpiperidin-3-ylcarbamate
((3R,4R)-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 4-Methyl-piperidin-3-ol 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyriMidine 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE (3SR,4SR)-1-benzyl-N,4-dimethylpiperidin-3-amine
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride 3-((3RS,4RS)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino) piperidin-1-yl)-3-oxopropanenitrile citric acid ((3SR,4RS-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 2-Chloro-3,7-dihydro-4H-pyrrolo[2,3-d]pyriMidin-4-one Tofacitinib
(3R,4R)-N,4-dimethyl-1-tosylpiperidin-3-amine N-((3RS,4RS)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3RS,4SR)-1-benzyl-N-methyl-4-methylpiperidin-3-amine bis-(hydrochloride)

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1-benzyl-4-methylpiperidin-3-one 4-Methyl-1-(phenylmethyl)-3-piperidinone 3-Piperidinone, 4-Methyl-1-(phenylMethyl)- Methyl-1-(phenylMethyl) 3-piperidone hydrochloride Tofacitinib Impurity 192 1-benzyl-4-methylpiperidin-3-on Tofacitinib Impurity 13 HCl Tofacitinib Impurity 192 Monomer Moxifloxacin Impurity 158 Tofacitinib Impurity 16 HCl 32018-96-5