CAY10574
- CAS No.
- 140651-18-9
- Chemical Name:
- CAY10574
- Synonyms
- CAN-508;CAY10574;Cdk9 Inhibitor II;CAN-508 (CAN508);4-((3,5-Diamino-1H-pyrazol-4-yl)diazenyl)phenol;4-[2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenol;Phenol, 4-[2-(3,5-diamino-1H-pyrazol-4-yl)diazenyl]-;CaMKII Inhibitor, CK59 - CAS 140651-18-9 - Calbiochem;inhibit,CAN 508,ATP-competitive,Cyclin dependent kinase,esophageal,cells,CDK,CAN508,Inhibitor,adenocarcinoma,HT-29,CAN-508
- CBNumber:
- CB62590428
- Molecular Formula:
- C9H10N6O
- Molecular Weight:
- 218.22
- MDL Number:
- MFCD09262258
- MOL File:
- 140651-18-9.mol
| Boiling point | 638.3±55.0 °C(Predicted) |
|---|---|
| Density | 1.67±0.1 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | DMF: 0.5 mg/ml; DMSO: 0.5 mg/ml |
| pka | 8.52±0.30(Predicted) |
| form | Yellow semi-solid |
| FDA UNII | ZG0O47K626 |
CAY10574 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 238811 | Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem | 140651-18-9 | 5mg | $289 | 2024-03-01 | Buy |
| Cayman Chemical | 10011247 | CAY10574 ≥95% | 140651-18-9 | 1mg | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 10011247 | CAY10574 ≥95% | 140651-18-9 | 5mg | $107 | 2024-03-01 | Buy |
| Cayman Chemical | 10011247 | CAY10574 ≥95% | 140651-18-9 | 10mg | $186 | 2024-03-01 | Buy |
| Cayman Chemical | 10011247 | CAY10574 ≥95% | 140651-18-9 | 50mg | $807 | 2024-03-01 | Buy |
CAY10574 Chemical Properties,Uses,Production
Uses
Cdk9 Inhibitor II is an ATP-competitive inhibitor of Cdk9 and moderate inhibitor of similar enzymes.
Definition
ChEBI: CAN-508 is a member of the class of pyrazoles that is 1H-pyrazole substituted by amino, (4-hydroxyphenyl)diazenyl, and amino groups at positions 3, 4 and 5, respectively. It is a CDK9 inhibitor (IC50 = 0.35 muM) with 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes. It has a role as an angiogenesis inhibitor, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of pyrazoles, a member of phenols, an aromatic amine and a monoazo compound.
General Description
A cell-permeable Olomoucine (Cat. Nos. 495620 & 495624) analog that acts as a CaMKII inhibitor (IC50<10 μM) and inhibits insulin-stimulated glucose uptake (IC50 ≤5 μM) and GLUT4 membrane translocation (IC50 = 100 μM) in 3T3-L1 adipocytes.
CAY10574 Preparation Products And Raw materials
Raw materials
Preparation Products
CAY10574 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3445 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8012 | 62 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |