| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:CaMKII Inhibitor, CK59 - CAS 140651-18-9 - Calbiochem
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:CAY10574
CAS:140651-18-9
Purity:95% Package:1G;10G;100G Remarks:Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, a
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| | CAY10574 Basic information |
| Product Name: | CAY10574 | | Synonyms: | CAY10574;Cdk9 Inhibitor II;4-[2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenol;CAN-508;CAN-508
(CAN508);CaMKII Inhibitor, CK59 - CAS 140651-18-9 - Calbiochem;inhibit,CAN 508,ATP-competitive,Cyclin dependent kinase,esophageal,cells,CDK,CAN508,Inhibitor,adenocarcinoma,HT-29,CAN-508;Phenol, 4-[2-(3,5-diamino-1H-pyrazol-4-yl)diazenyl]- | | CAS: | 140651-18-9 | | MF: | C9H10N6O | | MW: | 218.22 | | EINECS: | | | Product Categories: | | | Mol File: | 140651-18-9.mol |  |
| | CAY10574 Chemical Properties |
| Boiling point | 638.3±55.0 °C(Predicted) | | density | 1.67±0.1 g/cm3(Predicted) | | storage temp. | +2C to +8C | | solubility | DMF: 0.5 mg/ml; DMSO: 0.5 mg/ml | | pka | 8.52±0.30(Predicted) | | form | Yellow semi-solid |
| | CAY10574 Usage And Synthesis |
| Uses | Cdk9 Inhibitor II is an ATP-competitive inhibitor of Cdk9 and moderate inhibitor of similar enzymes. | | Definition | ChEBI: CAN-508 is a member of the class of pyrazoles that is 1H-pyrazole substituted by amino, (4-hydroxyphenyl)diazenyl, and amino groups at positions 3, 4 and 5, respectively. It is a CDK9 inhibitor (IC50 = 0.35 muM) with 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes. It has a role as an angiogenesis inhibitor, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of pyrazoles, a member of phenols, an aromatic amine and a monoazo compound. | | General Description | A cell-permeable Olomoucine (Cat. Nos. 495620 & 495624) analog that acts as a CaMKII inhibitor (IC50<10 μM) and inhibits insulin-stimulated glucose uptake (IC50 ≤5 μM) and GLUT4 membrane translocation (IC50 = 100 μM) in 3T3-L1 adipocytes. |
| | CAY10574 Preparation Products And Raw materials |
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