ChemicalBook >> CAS DataBase List >>INCB28060 Dihydrochloride
INCB28060 Dihydrochloride
- CAS No.
- 1197376-85-4
- Chemical Name:
- INCB28060 Dihydrochloride
- Synonyms
- INC-280 2HCl;INCB28060 2HCl;Capmatinib 2HCl;INCB28060 Dihydrochloride;Capmatinib Dihydrochloride;2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride;Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-, hydrochloride (1:2);Capmatinib,Apoptosis,c-Met/HGFR,INC 280,H441,INCB28060,INC280,orally active,Capmatinib 2HCl,INCB-28060,SNU-5,INC-280,Inhibitor,S114,INCB 28060,inhibit,U-87MG,ATP competitive,Balb/c nu/nu mice
- CBNumber:
- CB63167063
- Molecular Formula:
- C23H18ClFN6O
- Molecular Weight:
- 448.89
- MDL Number:
- MFCD30502991
- MOL File:
- 1197376-85-4.mol
Last updated:2023-12-29 17:22:15
| FDA UNII | Z0V2EW20JR |
|---|
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H371 |
| Precautionary statements | P260-P264-P270-P309+P311-P405-P501 |
INCB28060 Dihydrochloride Chemical Properties,Uses,Production
Description
INCB28060 Dihydrochloride is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.
Uses
INCB28060 dihydrochloride exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, INCB 28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.
INCB28060 Dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 60)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 906 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Hangzhou Cherry Pharmaceutical Technology Co.,ltd | 0571-81636070 | info@cherrypharmatech.com | CHINA | 274 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Nanjing Fred Technology Co., Ltd | +86-25-84696168 +86-15380713688 | Austin@fredbio.com | China | 2449 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4604 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Anqing Benro pharmachem Technology Co.,Ltd. | 05565209906 15391842992 | 794263564@qq.com | China | 111 | 58 |
| Tianjin Zhongcheng Mingyuan Technology Co., Ltd. | 13302022156 | 3506745780@qq.com | China | 171 | 58 |
Related articles
- Synthesis of Capmatinib Dihydrocholride
- Capmatinib Dihydrocholride is synthesised from a quinoline fragment and a bis-aryl fragment of capmatinib by a late cyclisatio....
- Dec 29，2023
1197376-85-4(INCB28060 Dihydrochloride)Related Search:
1of4
2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Dihydrochloride
INCB28060 2HCl
INCB28060 Dihydrochloride
Capmatinib 2HCl
INC-280 2HCl
Capmatinib Dihydrochloride
Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-, hydrochloride (1:2)
Capmatinib,Apoptosis,c-Met/HGFR,INC 280,H441,INCB28060,INC280,orally active,Capmatinib 2HCl,INCB-28060,SNU-5,INC-280,Inhibitor,S114,INCB 28060,inhibit,U-87MG,ATP competitive,Balb/c nu/nu mice
1197376-85-4
API
API