Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>GSK-J2 (sodium salt)

GSK-J2 (sodium salt)

GSK-J2 (sodium salt) Structure
GSK-J2 (sodium salt) structure
CAS No.
2108665-15-0
Chemical Name:
GSK-J2 (sodium salt)
Synonyms
GSK-J2 (sodium salt);3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-3-yl)pyrimidin-4-yl)amino)propanoicacid,monosodiumsalt
CBNumber:
CB64666440
Molecular Formula:
C22H24N5NaO2
Molecular Weight:
413.46
MDL Number:
MOL File:
2108665-15-0.mol
Last updated:2023-05-21 10:59:17
Request For Quotation

GSK-J2 (sodium salt) Properties

storage temp. Store at -20°C
solubility Soluble in DMSO
form A crystalline solid

GSK-J2 (sodium salt) price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 12056 GSK-J2 (sodium salt) ≥90% 2108665-15-0 1mg $36 2024-03-01 Buy
Cayman Chemical 12056 GSK-J2 (sodium salt) ≥90% 2108665-15-0 5mg $130 2024-03-01 Buy
Cayman Chemical 12056 GSK-J2 (sodium salt) ≥90% 2108665-15-0 10mg $223 2024-03-01 Buy
Cayman Chemical 12056 GSK-J2 (sodium salt) ≥90% 2108665-15-0 50mg $936 2024-03-01 Buy
AK Scientific 1438EN CID137699749 2108665-15-0 50mg $1139 2021-12-16 Buy
Product number Packaging Price Buy
12056 1mg $36 Buy
12056 5mg $130 Buy
12056 10mg $223 Buy
12056 50mg $936 Buy
1438EN 50mg $1139 Buy

GSK-J2 (sodium salt) Chemical Properties,Uses,Production

Description

The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.1,2 GSK-J2 is a pyridine regio-isomer of GSK-J1 which poorly inhibits JMJD3 (IC50 > 100 μM), making it an appropriate negative control for in vitro studies involving GSK-J1.3 For in vivo research, cell-permeable prodrug forms of GSK-J1 and GSK-J2 are available as GSK-J4 and GSK-J5 , respectively. See the Structural Genomics Consortium (SGC) website for more information.

References

1. Agger, K., Cloos, P.A.C., Christensen, J., et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development Nature 449(7163),731-734(2011).
2. Hübner, M.R., and Spector, D.L. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation Cold Spring Harb. Symp. Quant. Biol. 75,43-49(2010).
3. Kruidenier, L., Chung, C.W., Cheng, Z., et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response Nature 488,404-408(2012).

GSK-J2 (sodium salt) Preparation Products And Raw materials

Raw materials

Preparation Products

GSK-J2 (sodium salt) Suppliers

Global( 15)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Supplier Advantage
BOC Sciences 65
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
GSK-J2 (sodium salt) 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-3-yl)pyrimidin-4-yl)amino)propanoicacid,monosodiumsalt 2108665-15-0 C22H23N5O2HNa