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ChemicalBook >> CAS DataBase List >>N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel-

N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel-

N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- Structure
N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- structure
CAS No.
1263369-28-3
Chemical Name:
N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel-
Synonyms
CDK9-IN-2;CDK9 inhibitor 2;inhibit,Inhibitor,Cyclin dependent kinase,CDK,CDK9IN2,CDK9 IN 2,CDK-9-IN-2;N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diamine;N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel-;N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-[(3-fluorophenyl)methyl]-[2,4'-bipyridine]-2',6-diamine;[2,4'-Bipyridine]-2',6-diamine, N2'-(trans-4-aminocyclohexyl)-5'-chloro-N6-[(3-fluorophenyl)methyl]-
CBNumber:
CB72666609
Molecular Formula:
C23H25ClFN5
Molecular Weight:
425.93
MDL Number:
MFCD25562908
MOL File:
1263369-28-3.mol
Last updated:2023-07-12 16:50:50
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N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- Properties

Boiling point 603.1±55.0 °C(Predicted)
Density 1.302±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (117.39 mM; Need ultrasonic)
form Powder
pka 10.40±0.70(Predicted)

N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-1252 CDK9-IN-2 99.84% 1263369-28-3 5mg $240 2021-12-16 Buy
ChemScene CS-1252 CDK9-IN-2 99.84% 1263369-28-3 10mg $360 2021-12-16 Buy
ApexBio Technology A3295 CDK9inhibitor2 1263369-28-3 5mg $419 2021-12-16 Buy
ApexBio Technology A3295 CDK9inhibitor2 1263369-28-3 10mg $541 2021-12-16 Buy
ChemScene CS-1252 CDK9-IN-2 99.84% 1263369-28-3 50mg $960 2021-12-16 Buy
Product number Packaging Price Buy
CS-1252 5mg $240 Buy
CS-1252 10mg $360 Buy
A3295 5mg $419 Buy
A3295 10mg $541 Buy
CS-1252 50mg $960 Buy

N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- Chemical Properties,Uses,Production

Description

CDK9-IN-2 is a special cyclin-dependent kinase 9 (CDK9) inhibitor, extracted from patent WO/2012131594A1, compound CDKI(8), has an IC50 of 5 nM and 7 nM in H929 multiple myeloma(MM) cell line (72 hours) and A2058 skin cell line (72 hours), respectively.

in vitro

In Vitro:CDK9-IN-2 (200 nM) reduces the expression of MEPCE indicating that MEPCE is a pharmacodynamic (PD) marker for any CDK9 inhibitor. The expression of MCL1 protein is reduced 2 hours after treatment and is further reduced after 16 hour exposure to CDK9-IN-2 (500 nM)[1].

References

References:[1]. Michel Faure, et al. Pharmacodynamic markers associated with cyclin-dependent kinase inhibitors. From PCT Int. Appl. (2012), WO 2012131594A1.

N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- Preparation Products And Raw materials

Raw materials

Preparation Products

N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- Suppliers

Global( 46)Suppliers
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
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Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
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Supplier Advantage
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
GIHI CHEMICALS CO.,LIMITED 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
CDK9 inhibitor 2 N2'-((1r,4r)-4-aMinocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diaMine-rel- CDK9-IN-2 N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-[(3-fluorophenyl)methyl]-[2,4'-bipyridine]-2',6-diamine [2,4'-Bipyridine]-2',6-diamine, N2'-(trans-4-aminocyclohexyl)-5'-chloro-N6-[(3-fluorophenyl)methyl]- inhibit,Inhibitor,Cyclin dependent kinase,CDK,CDK9IN2,CDK9 IN 2,CDK-9-IN-2 N2'-(trans-4-Aminocyclohexyl)-5'-chloro-N6-(3-fluorobenzyl)-[2,4'-bipyridine]-2',6-diamine 1263369-28-3 C23H25ClFN5