E6005
- CAS No.
- 947620-48-6
- Chemical Name:
- E6005
- Synonyms
- E6005;CS-2517;RVT-501;lotamilast;E 6005;E-6005;RVT-501 E6005;E 6005: RVT-501;Lotamilast (RVT501;RVT501,Lotamilast,E 6005,RVT 501,E-6005,Inhibitor,Phosphodiesterase (PDE),inhibit;METHYL 4-((3-(6,7-DIMETHOXY-2-(METHYLAMINO)QUINAZOLIN-4-YL)PHENYL)CARBAMOYL)BENZOATE
- CBNumber:
- CB73170286
- Molecular Formula:
- C26H24N4O5
- Molecular Weight:
- 472.49
- MDL Number:
- MFCD28502071
- MOL File:
- 947620-48-6.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO:25.0(Max Conc. mg/mL);52.9(Max Conc. mM) |
| form | A solid |
| FDA UNII | TO043KKB9C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| NFPA 704 |
|
E6005 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 30203 | E6005 | 947620-48-6 | 5mg | $95 | 2024-03-01 | Buy |
| Cayman Chemical | 30203 | E6005 | 947620-48-6 | 25mg | $384 | 2024-03-01 | Buy |
| Cayman Chemical | 30203 | E6005 | 947620-48-6 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 30203 | E6005 | 947620-48-6 | 10mg | $172 | 2024-03-01 | Buy |
| TRC | R800003 | RVT501 | 947620-48-6 | 2.5mg | $65 | 2021-12-16 | Buy |
E6005 Chemical Properties,Uses,Production
Description
E6005 is an inhibitor of phosphodiesterase 4 (PDE4; IC50 = 2.8 nM). It is selective for PDE4 over PDE1, PDE2, PDE3, and PDE5 with only 46.1, 51.6, 69.4, and 57.4% inhibition, respectively, at 30 μM. It inhibits the production of various cytokines in isolated human lymphocytes and monocytes (IC50s = 0.49-3.1 nM). Topical application of E6005 (0.003-0.3%) reduces ear thickness in a mouse model of oxazolone-induced skin inflammation, as well as reduces oxazolone-induced scratching in mice. It reduces the severity of skin lesions in a model of mite-induced atopic dermatitis. Topical application of E6005 (0.03%) also inhibits the production of leukotriene B4 (LTB4; ) in mouse skin, as well as reduces scratching and cutaneous nerve firing induced by the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH2 in mice.
Uses
RVT 501 is a potent and selective inhibitor of human phosphodiesterase 4 (PDE4).
E6005 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 |