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ChemicalBook >> CAS DataBase List >> E6005

E6005

E6005 price.
  • $36 - $1800
  • Product name: E6005
  • CAS: 947620-48-6
  • MF: C26H24N4O5
  • MW: 472.49
  • EINECS:
  • MDL Number:MFCD28502071
  • Synonyms:E6005;RVT-501;lotamilast;E 6005: RVT-501;METHYL 4-((3-(6,7-DIMETHOXY-2-(METHYLAMINO)QUINAZOLIN-4-YL)PHENYL)CARBAMOYL)BENZOATE;RVT-501 E6005;methyl 4-[({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}amino)carbonyl]benzoate;CS-2517
Price14 Properties Safety Information Description
14 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 2.5mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • ManufacturerAK Scientific
  • Product number1822DC
  • Product descriptionMethyl4-((3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenyl)carbamoyl)benzoate
  • Packaging5mg
  • Price$203
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number30203
  • Product descriptionE6005
  • Packaging1mg
  • Price$36
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number30203
  • Product descriptionE6005
  • Packaging5mg
  • Price$95
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number30203
  • Product descriptionE6005
  • Packaging10mg
  • Price$172
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number30203
  • Product descriptionE6005
  • Packaging25mg
  • Price$384
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM219353
  • Product descriptionMethyl4-((3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenyl)carbamoyl)benzoate 97%
  • Packaging1g
  • Price$1681
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7517
  • Product descriptionLotamilast ≥98.0%
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7517
  • Product descriptionLotamilast ≥98.0%
  • Packaging10mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7517
  • Product descriptionLotamilast ≥98.0%
  • Packaging50mg
  • Price$588
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-7517
  • Product descriptionLotamilast ≥98.0%
  • Packaging100mg
  • Price$948
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10141
  • Product descriptionE6005 >98%
  • Packaging100mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10141
  • Product descriptionE6005 >98%
  • Packaging1g
  • Price$1800
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberR800003
  • Product descriptionRVT501
  • Packaging2.5mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberR800003
  • Product descriptionRVT501
  • Packaging25mg
  • Price$360
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1822DC Methyl4-((3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenyl)carbamoyl)benzoate 5mg $203 2021-12-16 Buy
Cayman Chemical 30203 E6005 1mg $36 2024-03-01 Buy
Cayman Chemical 30203 E6005 5mg $95 2024-03-01 Buy
Cayman Chemical 30203 E6005 10mg $172 2024-03-01 Buy
Cayman Chemical 30203 E6005 25mg $384 2024-03-01 Buy
Chemenu CM219353 Methyl4-((3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenyl)carbamoyl)benzoate 97% 1g $1681 2021-12-16 Buy
ChemScene CS-7517 Lotamilast ≥98.0% 5mg $120 2021-12-16 Buy
ChemScene CS-7517 Lotamilast ≥98.0% 10mg $180 2021-12-16 Buy
ChemScene CS-7517 Lotamilast ≥98.0% 50mg $588 2021-12-16 Buy
ChemScene CS-7517 Lotamilast ≥98.0% 100mg $948 2021-12-16 Buy
DC Chemicals DC10141 E6005 >98% 100mg $500 2021-12-16 Buy
DC Chemicals DC10141 E6005 >98% 1g $1800 2021-12-16 Buy
TRC R800003 RVT501 2.5mg $65 2021-12-16 Buy
TRC R800003 RVT501 25mg $360 2021-12-16 Buy

Properties

storage temp. :Store at -20°C
solubility :DMSO:25.0(Max Conc. mg/mL);52.9(Max Conc. mM)
form :A solid

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

E6005 is an inhibitor of phosphodiesterase 4 (PDE4; IC50 = 2.8 nM). It is selective for PDE4 over PDE1, PDE2, PDE3, and PDE5 with only 46.1, 51.6, 69.4, and 57.4% inhibition, respectively, at 30 μM. It inhibits the production of various cytokines in isolated human lymphocytes and monocytes (IC50s = 0.49-3.1 nM). Topical application of E6005 (0.003-0.3%) reduces ear thickness in a mouse model of oxazolone-induced skin inflammation, as well as reduces oxazolone-induced scratching in mice. It reduces the severity of skin lesions in a model of mite-induced atopic dermatitis. Topical application of E6005 (0.03%) also inhibits the production of leukotriene B4 (LTB4; ) in mouse skin, as well as reduces scratching and cutaneous nerve firing induced by the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH2 in mice.

Suppliers and manufacturers

ATK CHEMICAL COMPANY LIMITED
career henan chemical co
Chongqing Chemdad Co., Ltd
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific
Suzhou ARTK Medchem Co., Ltd.
Amadis Chemical Company Limited