5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM
![5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Structure](CAS/GIF/151126-84-0.gif)
- CAS No.
- 151126-84-0
- Chemical Name:
- 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM
- Synonyms
- CL 316243 DISODIUM;CL 316243 disodium s;CL 316243 DISODIUM SALT;5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM;5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylicaciddisodiumsalt;5-[(2R)-2-[[(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO]PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLIC ACID DISODIUM SALT
- CBNumber:
- CB7343089
- Molecular Formula:
- C20H18ClNNa2O7
- Molecular Weight:
- 465.79
- MDL Number:
- MFCD00907153
- MOL File:
- 151126-84-0.mol
5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Properties
| storage temp. | Desiccate at -20°C |
|---|---|
| solubility | H2O: >10 mg/mL |
| form | solid |
| color | white |
| Water Solubility | Soluble to 100 mM in water |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months. |
5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 1499 | CL316243disodiumsalt ≥98%(HPLC) | 151126-84-0 | 10 | $214 | 2021-12-16 | Buy |
| Tocris | 1499 | CL316243disodiumsalt ≥98%(HPLC) | 151126-84-0 | 50 | $870 | 2021-12-16 | Buy |
| TRC | C555003 | CL316243DisodiumSalt | 151126-84-0 | 5mg | $415 | 2021-12-16 | Buy |
| ApexBio Technology | B6766 | CL316243disodiumsalt | 151126-84-0 | 10mg | $243 | 2021-12-16 | Buy |
| ApexBio Technology | B6766 | CL316243disodiumsalt | 151126-84-0 | 1mg | $60 | 2021-12-16 | Buy |
5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Chemical Properties,Uses,Production
Description
CL-316243 (151126-84-0) is a potent and selective β3-adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and decreases blood insulin and glucose levels.1?CL-316243 induces functionally active mitochondrial uncoupling protein (UCP) in white fat.2?Active?in vivo.
Uses
CL 316243 Disodium Salt is a potent and highly selective β3-adrenoceptor agonist.
Biological Activity
Potent and highly selective β 3 -adrenoceptor agonist (EC 50 = 3 nM); > 10000-fold selective over β 1 and β 2 receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo .
in vitro
the compound was a potent stimulant of rat adipocyte lipolysis (β3 effect, ec50 = (3.0±0.3) x 10-8 m), had no effect on the rate of contraction of guinea pig atria (β1 effect, ec50 > 10-4 m), and had only a very limited ability to inhibit insulin-stimulated [14c] glucose incorporation into glycogen in isolated rat soleus muacle (β2 effect, ic50 = (3.0±1.0) x 10-5 m) [1].
in vivo
in rat, cl-316,243 treatment resulted in increased growth rates and significant changes in food consumption at the end of the 10-day treatment period. cl-316,243 treatment increased insulin responsiveness and sensitivity in non-insulin-resistant rodent species. the cl-316,243 induced increases in whole-body glucose disposal were due entirely to increases in adipose tissue glucose uptake, while muscle glucose uptake remained unaltered [2].
References
1) Yoshida?et al. (1994),?Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific beta 3-adrenoceptor agonist in yellow KK mice; Life Sci.,?54?491 2) Yoshida?et al. (1998),?β3-Adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers; Am. J. Physiol.,?274?E469
5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Preparation Products And Raw materials
Raw materials
Preparation Products
5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9901 | 58 | |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Jinan ponder chemical co. LTD | 0531-0000 | thinklifescience@163.com | China | 19690 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
151126-84-0(5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM)Related Search:
1of4