DL-Serine
- CAS No.
- 302-84-1
- Chemical Name:
- DL-Serine
- Synonyms
- SERINE;serin;DL-SER;DL-Serin;DL-Ser-OH;DL-SERINE;Serine, dl-;H-DL-SER-OH;DL-SERINE,FCC;DL-Serine >
- CBNumber:
- CB7345179
- Molecular Formula:
- C3H7NO3
- Molecular Weight:
- 105.09
- MDL Number:
- MFCD00064223
- MOL File:
- 302-84-1.mol
- MSDS File:
- SDS
| Melting point | 240 °C (dec.) (lit.) |
|---|---|
| Boiling point | 197.09°C (rough estimate) |
| Density | 1.53 |
| refractive index | 1.4368 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | H2O: soluble |
| form | Crystalline Powder |
| pka | 2.19(at 25℃) |
| color | White |
| Odor | Odorless |
| Water Solubility | 50.23 g/L (25 ºC) |
| Merck | 14,8460 |
| BRN | 1721402 |
| LogP | -3.460 |
| CAS DataBase Reference | 302-84-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 00PAR1C66F |
| NIST Chemistry Reference | DL-Serine(302-84-1) |
| EPA Substance Registry System | Serine (302-84-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P302+P352-P305+P351+P338-P362+P364 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | VT8100000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29225000 | |||||||||
| NFPA 704 |
|
DL-Serine price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S4375 | DL-Serine ≥98% (TLC) | 302-84-1 | 1kg | $282 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.41235 | DL-Serine for synthesis | 302-84-1 | 100g | $90.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | 68353 | DL-Serine analytical standard | 302-84-1 | 100mg | $51.8 | 2022-05-15 | Buy |
| TCI Chemical | S0034 | DL-Serine >98.0%(T) | 302-84-1 | 25g | $21 | 2024-03-01 | Buy |
| TCI Chemical | S0034 | DL-Serine >98.0%(T) | 302-84-1 | 500g | $143 | 2024-03-01 | Buy |
DL-Serine Chemical Properties,Uses,Production
Description
DL-Serine is a kind of neutral aliphatic amino acids containing hydroxyl groups with polarity but being uncharged, and belongs to nonessential amino acids for human body. It has a high content in sericin silk protein and fibroin protein. It can be formed from the methyl transfer reaction of glycine. It can also be converted to pyruvate or hydroxy pyruvate through deamination. It is also an important raw material for in vivo synthesis of choline and cysteine.
Chemical Properties
DL-Serine is a kind of colorless monoclinic columnar or lamellae crystal. It is soluble in water (at 20℃, the water solubility is 380g/L), insoluble in ether and ethanol; Decomposition point: 246℃.
Uses
DL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer’s treatment.
Application
Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2. Serine helps retain the skin's moisture balance.
Preparation
DL-serine is obtained by complexing glycine under the catalysis of copper ions and then combining with formaldehyde under alkaline conditions, followed by acidification, ion exchange, and crystallization in ethanol.?
Definition
ChEBI: Serine is an alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. It has a role as a fundamental metabolite. It is an alpha-amino acid and a polar amino acid. It contains a hydroxymethyl group. It is a conjugate base of a serinium. It is a conjugate acid of a serinate. It is a tautomer of a serine zwitterion.
Synthesis Reference(s)
Canadian Journal of Chemistry, 33, p. 1119, 1955 DOI: 10.1139/v55-131
The Journal of Organic Chemistry, 35, p. 1505, 1970 DOI: 10.1021/jo00830a054
Biochem/physiol Actions
NMDA agonist acting at the glycine site; precursor of glycine by serine hydroxymethyltransferase
Safety Profile
When heated to decomposition emits toxic fumes of NOx.
in vitro
DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV).
Subcutaneous injection of DL-serine increases the number and size of renal tubular cell tumors in male W rats treated with 500 or 1,000 ppm N-ethyl-N-hydroxyethylnitrosamine.
DL-Serine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Apeloa Pharmaceutical Co., Ltd. | +86-0571-87635730 +8615858229168 | chem1022@hengdian-group.com | China | 1469 | 58 |
| DONBOO AMINO ACID COMPANY | +8613063595538 | donboo@donboo.com | China | 9365 | 58 |
| Maanshan Tiantai Biotechnology Co., Ltd. | +86-0555-8889890 +86-17356584060 | GM@tiantaibio-tech.com | China | 72 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Wuhan Quanjinci New Material Co.,Ltd. | +8615271838296 | kyra@quanjinci.com | China | 1532 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 | sales@thbiochem.com | CHINA | 305 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
View Lastest Price from DL-Serine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | DL-Serine
302-84-1
|
US $0.00-0.00 / KG | 1KG | 99% | 66000kg/Month | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2023-11-29 | DL-Serine
302-84-1
|
US $50.00 / kg | 1kg | 0.99 | 1000000tons | Wuhan Quanjinci New Material Co.,Ltd. | |
 |
2023-09-06 | Quartz
302-84-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |