Carbidopa Monohydrate
- CAS No.
- 38821-49-7
- Chemical Name:
- Carbidopa Monohydrate
- Synonyms
- lodosyn;CARBIDOPA;Carbidopa RS;CARBIDOPA,USP;Carbidopa CRS;CARBIDOPA HYDRATE;Carbidopa (400 mg);Carbidopa(CEP/FDA);Carbidopa Capsules;CARBIDOPA 1-HYDRATE
- CBNumber:
- CB7445183
- Molecular Formula:
- C10H16N2O5
- Molecular Weight:
- 244.25
- MDL Number:
- MFCD00889211
- MOL File:
- 38821-49-7.mol
- MSDS File:
- SDS
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
|---|---|
| solubility | Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of mineral acids. |
| color | White to Off-White |
| CAS DataBase Reference | 38821-49-7(CAS DataBase Reference) |
| FDA UNII | MNX7R8C5VO |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MW5300000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2928002500 | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,148mg/kg (148mg/kg),SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYEBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974. | |||||||||
| NFPA 704 |
|
Carbidopa Monohydrate price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR1655 | Carbidopa Pharmaceutical Secondary Standard; Certified Reference Material | 38821-49-7 | 1g | $114 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP060 | Carbidopa British Pharmacopoeia (BP) Reference Standard | 38821-49-7 | 100MG | $229 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1095506 | Carbidopa United States Pharmacopeia (USP) Reference Standard | 38821-49-7 | 400mg | $436 | 2024-03-01 | Buy |
| TCI Chemical | C2450 | Carbidopa Monohydrate >98.0%(HPLC)(T) | 38821-49-7 | 1g | $73 | 2024-03-01 | Buy |
| TCI Chemical | C2450 | Carbidopa Monohydrate >98.0%(HPLC)(T) | 38821-49-7 | 100mg | $25 | 2024-03-01 | Buy |
Carbidopa Monohydrate Chemical Properties,Uses,Production
Chemical Properties
white or yellowish-white powder. almost odorless. combined with levodopa for Parkinson's disease and Parkinson's syndrome.
Originator
Sinemet,Merck Sharp and Dohme,Italy,1974
Uses
Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth.
Uses
Carbidopa may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
Definition
ChEBI: Carbidopa is the hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. It has a role as an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor, an antiparkinson drug, a dopaminergic agent and an antidyskinesia agent. It is a member of hydrazines, a hydrate, a monocarboxylic acid and a member of catechols. It contains a carbidopa (anhydrous).
brand name
Lodosyn (Bristol-Myers Squibb).
Therapeutic Function
Muscle relaxant, Antiparkinsonian
General Description
Carbidopa, (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid, is a whitecrystalline powder, slightly soluble in water (pKa＝7.8).Carbidopa is absorbed slower than levodopa and is 36%plasma protein bound.Carbidopa is metabolized to twomain metabolites (α-methyl-3-methoxy-4-hydroxyphenylpropionicacid and α-methyl-3,4-dihydroxyphenylpropionicacid). These two metabolites are primarily eliminated in theurine unchanged or as glucuronide conjugates. Unchangedcarbidopa accounts for 30% of the total urinary excretion.No drug interactions have been described.
Carbidopa Monohydrate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| APOLLO HEALTHCARE RESOURCES | +6596580999 | sales@apollo-healthcare.com.sg | Singapore | 400 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Casorganics US Corp | +17326109938 | sales@casorganics.com | CHINA | 174 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
View Lastest Price from Carbidopa Monohydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-16 | Carbidopa
38821-49-7
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | |
 |
2023-01-31 | Carbidopa Capsules
38821-49-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-01-12 | Carbidopa Monohydrate
38821-49-7
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Carbidopa
38821-49-7
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
-
- Carbidopa Capsules
38821-49-7
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Carbidopa Monohydrate
38821-49-7
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
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