CAERULOMYCIN A
- CAS No.
- 21802-37-9
- Chemical Name:
- CAERULOMYCIN A
- Synonyms
- CERULOMYCIN;CAERULOMYCIN;AERULOMYCIN A;Carulomycin A;CAERULOMYCIN A;Caerulomycin, Cerulomycin;CeruloMycin, CaeruloMycin A;Fungal,Antibiotic,Caerulomycin A,inhibit,Inhibitor;4-Methoxy-2,2'-bipyridine-6-carbaldehyde (E)-oxime;(E)-4-Methoxy-[2,2'-bipyridine]-6-carbaldehyde oxime
- CBNumber:
- CB7484496
- Molecular Formula:
- C12H11N3O2
- Molecular Weight:
- 229.23
- MDL Number:
- MFCD03093715
- MOL File:
- 21802-37-9.mol
- MSDS File:
- SDS
| Melting point | 173 °C |
|---|---|
| Boiling point | 420.0±45.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 10 mg/ml). |
| form | solid |
| pka | 9.89±0.50(Predicted) |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
CAERULOMYCIN A price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C6374 | Caerulomycin A from | 21802-37-9 | 1mg | $449 | 2024-03-01 | Buy |
| Cayman Chemical | 27625 | Caerulomycin A | 21802-37-9 | 1mg | $340 | 2024-03-01 | Buy |
| Cayman Chemical | 27625 | Caerulomycin A | 21802-37-9 | 5mg | $1186 | 2024-03-01 | Buy |
| TRC | C700030 | Caerulomycin A | 21802-37-9 | 1mg | $395 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546133 | Caerulomycin A >98% | 21802-37-9 | 100μg | $209.1 | 2021-12-16 | Buy |
CAERULOMYCIN A Chemical Properties,Uses,Production
Description
Caerulomycin A (21802-37-9) chemically novel and potent immunosuppressive agent. Suppresses T cell activation and IFN7gamma; secretion?in vitro?and?in vivo.1 Caerulomycin A induces expansion of regulatory T cells by via interfering with IFNγ -induced STAT1 signaling.2
Uses
Caerulomycin A is a pyridine derived antiobiotic with a broad spectrum of bioactivity.
Uses
Caerulomycin is a rare and unusual antibiotic containing a core 2, 2’-bispyridyl with an oxime substituent, produced by a strain of Streptomyces caeruleus isolated in Canada in 1959. Caerulomycin is active against fungi and some protozoans, and is weakly active against bacteria. While its discovery has stimulated some synthetic effort, little is known about the mode and spectrum of action of caerulomycin.
Definition
ChEBI: Caerulomycin A is a pyridine alkaloid that is 2,2'-bipyridine substituted by a methoxy group at position 4 and a (E)-(hydroxyimino)methyl group at position 6. Isolated from the marine-derived actinomycete Actinoalloteichus cyanogriseus, it exhibits antineoplastic activity. It has a role as an antineoplastic agent, a marine metabolite and a bacterial metabolite. It is an aldoxime, an aromatic ether, a member of bipyridines and a pyridine alkaloid. It derives from a hydride of a 2,2'-bipyridine.
References
1) Singla?et al. (2014),?Caerulomycin A suppresses immunity by inhibiting T cell activity; PLoS One,?9(10)?e107051 2) Gurram?et al. (2014),?Caerulomycin A enhances transforming growth factor-beta (TGF-β)-Smad3 protein signaling by suppressing interferon-gamma (IFN-γ)-signaling to expand regulatory T cells (Tregs); J. Biol. Chem.?289?17515
CAERULOMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
CAERULOMYCIN A Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | 13119157289@163.com | China | 2971 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
View Lastest Price from CAERULOMYCIN A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | AERULOMYCIN A
21802-37-9
|
US $1.00 / g | 1g | ≥98% | g/kg/Ton | Career Henan Chemical Co |
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- AERULOMYCIN A
21802-37-9
- US $1.00 / g
- ≥98%
- Career Henan Chemical Co