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FR179642 (hydrate)

CAS No.
1392483-15-6
Chemical Name:
FR179642 (hydrate)
Synonyms
Mikafin nucleus;FR179642 (hydrate);1-[(4R,5R)-4,5-dihydroxy-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]-pneumocandin A0, hydrate;5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-Amino-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,11,12,15-tetrahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl hydrogen sulfate xhydrate
CBNumber:
CB76197862
Molecular Formula:
C35H54N8O21S
Molecular Weight:
954.91
MDL Number:
MOL File:
1392483-15-6.mol
Last updated:2023-05-21 10:59:17

FR179642 (hydrate) Properties

storage temp. Store at -20°C
solubility DMSO: slightly, warmed,Methanol: slightly, warmed
form A solid

FR179642 (hydrate) Chemical Properties,Uses,Production

Biological Activity

FR179642 is the cyclic peptide nucleus of the lipopeptide antifungal FR901379 and an intermediate in the synthesis of the echinocandin antifungal FK463 .1,2

References

1.Tomishima, M., Ohki, H., Yamada, A., et al.FK463, a novel water-soluble echinocandin lipopeptide: Synthesis and antifungal activityJ. Antibiot. (Tokyo)52(7)674-676(1999) 2.Ueda, S., Shibata, T., Ito, K., et al.Cloning and expression of the FR901379 acylase gene from Streptomyces sp. no. 6907J. Antibiot. (Tokyo)64(2)169-175(2011)

FR179642 (hydrate) Preparation Products And Raw materials

Raw materials

Preparation Products

FR179642 (hydrate) Suppliers

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FR179642 (hydrate) 1-[(4R,5R)-4,5-dihydroxy-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]-pneumocandin A0, hydrate Mikafin nucleus 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-9-Amino-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,11,12,15-tetrahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl hydrogen sulfate xhydrate 1392483-15-6