2,4-Pyridinedicarboxylic acid
- CAS No.
- 499-80-9
- Chemical Name:
- 2,4-Pyridinedicarboxylic acid
- Synonyms
- 2,4-PDCA;2, 4-PDCA;lutidinicaci;LUTIDINIC ACID;4-Lutidinic Acid;2,4-LUTIDINIC ACID;RARECHEM AL BO 0286;2,4-Dicarboxypyridine;Tuobisite Impurity 20;Tuobisite Impurity 10
- CBNumber:
- CB7678217
- Molecular Formula:
- C7H5NO4
- Molecular Weight:
- 167.12
- MDL Number:
- MFCD00006296
- MOL File:
- 499-80-9.mol
- MSDS File:
- SDS
| Melting point | 243-246 °C |
|---|---|
| Boiling point | 295.67°C (rough estimate) |
| Density | 1.5216 (rough estimate) |
| vapor pressure | 0.001Pa at 25℃ |
| refractive index | 1.6280 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | 2.49g/l |
| form | Crystalline Powder |
| pka | 2.15(at 25℃) |
| color | White to almost white |
| Water Solubility | Soluble in water at 20°C 4.5 g/L. |
| λmax | 258nm(MeOH aq.)(lit.) |
| BRN | 131631 |
| LogP | 0.57 |
| CAS DataBase Reference | 499-80-9(CAS DataBase Reference) |
| FDA UNII | AFI29F0TVL |
| EPA Substance Registry System | 2,4-Pyridinedicarboxylic acid (499-80-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280a-P304+P340-P405-P501a-P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-26 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29333999 | |||||||||
| NFPA 704 |
|
2,4-Pyridinedicarboxylic acid price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.21052 | 2,4-Pyridinedicarboxylic acid for synthesis | 499-80-9 | 10g | $148 | 2024-03-01 | Buy |
| Sigma-Aldrich | 04473 | 2,4-Pyridinedicarboxylic acid ≥98.0% | 499-80-9 | 5g | $252 | 2024-03-01 | Buy |
| TCI Chemical | P0553 | 2,4-Pyridinedicarboxylic Acid min. 98.0 % | 499-80-9 | 25G | $132 | 2023-06-20 | Buy |
| TCI Chemical | P0553 | 2,4-Pyridinedicarboxylic Acid Hydrate >98.0%(GC)(T) | 499-80-9 | 5g | $44 | 2021-12-16 | Buy |
| TCI Chemical | P2416 | 2,4-Pyridinedicarboxylic Acid >98.0%(GC) | 499-80-9 | 5g | $69 | 2024-03-01 | Buy |
2,4-Pyridinedicarboxylic acid Chemical Properties,Uses,Production
Chemical Properties
white to almost white crystalline powder
Uses
2,4-Pyridinedicarboxylic Acid is a jumonji C (JmjC) histone demethylase inhibitor.
Uses
2,4-Pyridinedicarboxylic acid is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. 2,4-Pyridinedicarboxylic acid has been used in a study to develop an assay that represents the first report of a RapidFire mass spectrometery assay for an epigenetics target.
Definition
ChEBI: A pyridinedicarboxylic acid carrying carboxy groups at positions 2 and 4.
Flammability and Explosibility
Not classified
Biological Activity
2,4-pyridinedicarboxylic acid (2,4-pdca) is an inhibitor of histone lysine-specific demethylases that targets on jmjd2a (kdm4a), kdm4c, kdm4e (ic50, 1.4 μm), kdm5b (ic50, 3 μm), kdm6a and other 2-oxogynases [1][2].histone lysine-specific demethylases jmjd2a (kdm4a) and kdm4c are both members of the jumonji domain 2 (jmjd2) family and function as trimethylation-specific demethylases, converting specific trimethylated histone residues to the dimethylated form. kdm5b is an h3k4me3⁄ me2-specific lysine demethylase [1][2].2,4-pyridinedicarboxylic acid (2,4-pdca) is an inhibitor of jmjd2a (kdm4a), kdm4c and kdm5b. in the fdh-coupled assay, 2,4-pdca inhibited cckdm5b with ic50 value of 3 ± 1 μm. in maldi-tof analysis of h3(1-21)k4me3, 2,4-pdca reduced the level of h3(1-15) induced by cckdm5b. in u2-os cells transfected with kdm5b, 2,4-pdca inhibited the decrease of h3k4me3 [1]. in hg-treated vsmcs, 2,4-pdca (1.0 mm) inhibited jmjd2a and hg-induced proliferation in a concentration-dependent way, and inhibited hg-induced migration. 2,4-pdca also reduced the mrna and protein levels of mcp-1 and il-6 [2].in diabetic rats, 2,4-pdca (7.5 mg/kg/d) reduced neointimal area and i/m ratio in the injured arteries 28 days after injury. 2,4-pdca also inhibited the percentage of pcna-positive cells in the neointima [2].
References
[1]. kristensen lh, nielsen al, helgstrand c, et al. studies of h3k4me3 demethylation by kdm5b/jarid1b/plu1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor. febs j, 2012, 279(11): 1905-1914.
[2]. qi h, jing z, xiaolin w, et al. histone demethylase jmjd2a inhibition attenuates neointimal hyperplasia in the carotid arteries of balloon-injured diabetic rats via transcriptional silencing: inflammatory gene expression in vascular smooth muscle cells. cell physiol biochem, 2015, 37(2): 719-734.
2,4-Pyridinedicarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Chengdu Feibo Pharm Technology Co., Ltd | 15982321820 | abby@arkpharm.com | CHINA | 3279 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
View Lastest Price from 2,4-Pyridinedicarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-05 | 2,4-Pyridinedicarboxylic acid
499-80-9
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-10-16 | 2,4-Pyridinedicarboxylic acid
499-80-9
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-09-06 | 2,4-Pyridinedicarboxylic acid
499-80-9
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. |
-
- 2,4-Pyridinedicarboxylic acid
499-80-9
- US $5.00-0.10 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 2,4-Pyridinedicarboxylic acid
499-80-9
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- 2,4-Pyridinedicarboxylic acid
499-80-9
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
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